A Phase 1, Randomized, Double-Blind, Single-Dose, Placebo-Controlled Safety, Tolerability, And Pharmacokinetic/Pharmacodynamic Study Of Evolocumab In Healthy Chinese Subjects [0.03%]
Evolocumab在健康受试者中的I期、随机、双盲、单次给药、安慰剂对照的安全性、耐受性和药代/药效学研究
Chao Liu,Hong Lu,Fei Yuan et al.
Chao Liu et al.
Purpose: Evolocumab is a human monoclonal antibody that reduces circulating low-density lipoprotein cholesterol (LDL-C) by inhibiting proprotein convertase subtilisin/kexin type 9 (PCSK9). Data on evolocumab pharmacokinet...
Vitamin B12 deficiency presenting as pseudo-thrombotic microangiopathy: a case report and literature review [0.03%]
维生素B12缺乏导致的假性血栓性微血管病：一例报告及文献回顾
Yazan Fahmawi,Yesica Campos,Moh&#x;d Khushman et al.
Yazan Fahmawi et al.
Pseudo-thrombotic microangiopathy (pseudo-TMA) is a recognized, yet uncommon, clinical presentation of vitamin B12 deficiency. Patients with pseudo-TMA present with microangiopathic hemolytic anemia (MAHA), thrombocytopenia and schistocytes...
Differential pharmacology and clinical utility of dapagliflozin in type 2 diabetes [0.03%]
达格列净的药理学差异及其在2型糖尿病中的临床应用价值
Ioanna Papakitsou,George Vougiouklakis,Moses S Elisaf et al.
Ioanna Papakitsou et al.
Dapagliflozin belongs in the family of sodium-glucose cotransporter 2 (SGLT2) inhibitors and acts by reducing glucose reabsorption in the proximal tubule. The aim of this review is to present the differential pharmacology and clinical utili...
Approach to residual dizziness after successfully treated benign paroxysmal positional vertigo: effect of a polyphenol compound supplementation [0.03%]
成功治疗良性阵发性位置性眩晕后的残余头晕的处理方法：多酚类化合物补充的作用
Augusto Pietro Casani,Elena Navari,Roberto Albera et al.
Augusto Pietro Casani et al.
Purpose: To assess if a polyphenol compound supplementation (Vertigoval®) could improve residual dizziness earlier after benign paroxysmal positional vertigo (BPPV) and relieve patients from this disabling symptomatology...
Role of the pharmacist in improving inhaler technique and asthma management in rural areas in Jordan [0.03%]
约旦农村地区药剂师在改善吸入技术及哮喘管理中的作用
Iman A Basheti,Yara B Salhi,Mariam M Basheti et al.
Iman A Basheti et al.
Introduction: Pharmacists can have a valuable role in educating patients on correct inhaler technique leading to improved asthma management. Rural areas can benefit from the role of the pharmacist considering the barriers...
Bioavailability and swallowability of an age-appropriate, delayed-release mesalamine formulation in healthy volunteers [0.03%]
一项在健康志愿者中的研究：评价一种针对儿童的美沙拉秦缓释制剂的生物利用度和吞咽性的研究
Abhijeet Jakate,Brian McNamee,Donald Burkindine
Abhijeet Jakate
Objective: Delayed-release mesalamine 400 mg capsules containing four 100 mg tablets have been developed for children with ulcerative colitis who have difficulty swallowing. Bioavailability of the mesalamine capsules was compared with exist...
J A Gilreath,L Tchertanov,M W Deininger
J A Gilreath
Mastocytosis is a myeloproliferative neoplasm characterized by expansion of abnormal mast cells (MCs) in various tissues, including skin, bone marrow, gastrointestinal tract, liver, spleen, or lymph nodes. Subtypes include indolent systemic...
Reproducibility of nasal allergen challenge responses in adults with allergic rhinitis [0.03%]
过敏性鼻炎成人患者鼻内致敏原激发反应的重复性研究结果
Charles T Pantin,Thomas Southworth,Kristiane Wetzel et al.
Charles T Pantin et al.
Background: Allergic rhinitis is characterized by nasal inflammation in response to allergen exposure. Nasal allergen challenges are used in clinical trials evaluating drug effects. Reproducibility of nasal secretion cyto...
Current perspective on the role of insulin and glucagon in the pathogenesis and treatment of type 2 diabetes mellitus [0.03%]
当前关于胰岛素和胰高血糖素在2型糖尿病发病机制和治疗中作用的观点
Ashutosh Ojha,Utkarsh Ojha,Raihan Mohammed et al.
Ashutosh Ojha et al.
According to the World Health Organization, 422 million adults worldwide live with diabetes mellitus (DM), a significant portion of whom have type 2 diabetes. The discovery of insulin as a key regulator of glucose metabolism has revolutioni...
Effects of formulation types on pharmacodynamics of warfarin in patients with cerebral infarction and dysphagia [0.03%]
不同种类制剂对脑梗死伴吞咽困难患者华法林药代动力学的影响研究
Young-Ji Kim,Jong-Woo Jeong,Youngshin Song et al.
Young-Ji Kim et al.
Purpose: The purpose of this study was to investigate the effects of the type of formulation on the efficacy of warfarin. Materials and methods: ...