Exosomal miR-21 Derived from Paclitaxel-Resistant Breast Cancer Cells Promotes Chemoresistance in Breast Cancer via p53/PI3K/AKT/mTOR Signaling [0.03%]
紫杉醇耐药乳腺癌细胞来源的外泌体miR-21通过p53/PI3K/AKT/mTOR信号促进乳腺癌产生耐药性
Yanyan Wang,Qing Cai
Yanyan Wang
Objective: To investigate whether exosomes derived from paclitaxel (PTX)-resistant breast cancer cells confer chemoresistance to parental cells and to explore the involvement of the p53/PI3K/AKT/mTOR signaling pathway in ...
Long Non-Coding RNA PVT1 Promotes Doxorubicin Resistance by Inhibiting Ferroptosis in Breast Cancer [0.03%]
长链非编码RNA PVT1通过抑制铁死亡促进多柔比星耐药性在乳腺癌中的作用
Dan Zhao,Zheqiong Tan,Weiqun Chen et al.
Dan Zhao et al.
Background: There is growing evidence that long non-coding RNAs (lncRNAs) play crucial roles in cancer progression and therapy. Our previous study showed that the lncRNA plasmacytoma variant translocation 1 (PVT1) regulat...
Integrative Network-Based Transcriptomic Analysis Identifies Niclosamide as a Candidate Repositioned Drug for Breast Cancer [0.03%]
整合网络分析揭示尼克地尔作为乳腺癌重定位药物的候选者
Busra Aydin,Beyza Nur Okutan,Fatmanur Elif Sara et al.
Busra Aydin et al.
Purpose: Breast cancer (BC) is a highly heterogeneous malignancy, and current treatments often suffer from toxicity, limited selectivity, and high cost. This study aimed to integrate transcriptome-level data, multi-layere...
Prognostic Significance of Pretreatment Mean Platelet Volume in Patients with Recurrent or De Novo Metastatic Breast Cancer: A Single-Center Retrospective Study [0.03%]
血小板体积与乳腺癌复发或新发转移灶患者的预后关系：单中心回顾性研究
Zeynep Sıla Gökdere,Damla Günenç,Serdar Sezer et al.
Zeynep Sıla Gökdere et al.
Background: Breast cancer is the most prevalent malignancy among womificant advances in systemic therapies, metastatic breast cancer remains largely incurable, highlighting the need for reliable prognostic biomarkers. Mea...
Lipid Metabolic Reprogramming in Breast Cancer: Mechanisms and Emerging Therapeutic Strategies [0.03%]
乳腺癌中的脂质代谢重构：机制和新兴治疗策略
Xuliren Wang,Yuanyuan Zhao,Siqi Peng et al.
Xuliren Wang et al.
Breast cancer remains the most commonly diagnosed malignancy among women worldwide, with a steadily increasing incidence. Lipid metabolic reprogramming is increasingly recognized as both a hallmark and a fundamental driver of breast cancer ...
Estrogen-Driven Breast Carcinogenesis in a Rat Model is Linked to Retroelement Activation and Inflammation and is Susceptible to Lamivudine Treatment [0.03%]
雌激素驱动的大鼠乳腺癌的发生发展与古病毒元件激活及炎症相关并可被 lamivudine 治疗抑制
Valentina Evdokimova,Zhenbo Zhang,Peter Ruzanov et al.
Valentina Evdokimova et al.
Background: Despite significant progress in treating estrogen receptor (ER)-positive breast cancer (BC), the recurrence risk remains high and mechanisms driving initial ductal tumorigenesis is unclear. Given an emerging r...
miR-1911-3p Regulates Malignant Biological Behaviors and Glycolytic Activity of Triple-Negative Breast Cancer via FBLN5 [0.03%]
microRNA-1911-3p通过FBELN5调节三阴性乳腺癌的恶性生物学行为和糖酵解活性
Linna Kong,Huihui Zhang,Xufang Sui et al.
Linna Kong et al.
Background and objectives: Based on previous reports demonstrating the clinical potential of miR-1911-3p in breast cancer, its function and mechanisms in the development of TNBC were investigated, aiming to identify a nov...
Suppressing M2 Macrophage Polarization by Glycine Combined with β-Elemene via the IL-6/JAK2/STAT3 Signaling Pathway to Inhibit Triple-Negative Breast Cancer Progression [0.03%]
甘氨酸联合β榄烯通过抑制IL-6/JAK2/STAT3信号通路M2型肿瘤相关巨噬细胞极化而抑制三阴性乳腺癌进展
Huan Li,Yu Cheng,Yanyun Meng et al.
Huan Li et al.
Background: Triple-negative breast cancer (TNBC) is an aggressive subtype with poor prognosis, closely associated with an imbalanced tumor immune microenvironment. Tumor-associated macrophages (TAMs) play a crucial role i...
Application of Shear Wave Elastography Combined with Tumor Markers in the Differential Diagnosis of Benign and Malignant Breast Masses [0.03%]
剪切波弹性成像联合肿瘤标志物鉴别诊断乳腺良恶性肿块的应用价值研究
Jing Liu,Yuke Zhang,Qiang Zhou
Jing Liu
Purpose: To explore the value of combined quantitative shear wave elastography (SWE) parameters and breast cancer molecular markers for the differential diagnosis of benign and malignant breast masses. ...
Expression Profiling of SWI/SNF Complex Subunits in Triple-Negative Breast Cancer Using Tissue Microarray and Immunohistochemistry [0.03%]
利用组织芯片和免疫组化技术研究SWI/SNF复合体成员在三阴性乳腺癌中的表达谱分布特点
Shang Wang,Chen Gao,Qi Wang et al.
Shang Wang et al.
Introduction: The SWI/SNF (SWItch/Sucrose Non - Fermentable) complex is a multi - subunit, ATPase - dependent chromatin - remodeling complex involved in regulating key cellular processes. Tumors with SWI/SNF loss tend to ...