Sulfation of fulvestrant by human liver cytosols and recombinant SULT1A1 and SULT1E1 [0.03%]
人肝胞浆和重组SULT1A1及SULT1E1对氟维司群硫酸化的催化作用
Vineetha Koroth Edavana,Xinfeng Yu,Ishwori B Dhakal et al.
Vineetha Koroth Edavana et al.
Fulvestrant (Faslodex™) is a pure antiestrogen that is approved to treat hormone receptor-positive metastatic breast cancer in postmenopausal women. Previous studies have demonstrated that fulvestrant metabolism in humans involves cytochro...
Wei Zhang,R Stephanie Huang,M Eileen Dolan
Wei Zhang
The goal of personalized medicine is to recommend drug treatment based on an individual's genetic makeup. Pharmacogenomic studies utilize two main approaches: candidate gene and whole-genome. Both approaches analyze genetic variants such as...