Massive Hepatocellular Carcinoma with Insufficient Future Liver Remnant Achieved Complete Response After Two-Stage Hepatectomy Combined with Hepatic Arterial Infusion Chemotherapy and Lenvatinib-sintilimab: A Case Report [0.03%]
肝动脉灌注化疗联合仑伐替尼和信迪利单抗桥接两期手术切除获得完全缓解的巨大肝癌一例报告
Ruoxiang Xu,Mingrui Zhang,Zhiming Zeng et al.
Ruoxiang Xu et al.
Massive hepatocellular carcinoma (HCC) is not suitable for radical surgery due to the factors of high tumor burden and poor postoperative liver function tolerance. There are few reports on the conversion therapy for HCC with insufficient fu...
Construction and Validation of Multi-Omics Predictive Models for Colorectal Cancer Using Machine-Learning Approaches [0.03%]
基于机器学习的结直肠癌多组学预测模型的构建与验证
Zhenhuan Lu,Xiaowen Li,Zhiping Liang et al.
Zhenhuan Lu et al.
Objective: To construct and externally validate a multi-omics nomogram that uses only routine clinicopathological variables to predict tumor mutational burden (TMB), microsatellite instability (MSI), NTRK/PIK3CA mutation ...
Clinical Outcomes of Osimertinib Combined with Platinum-Based Chemotherapy in EGFR-Mutant Non-Small Cell Lung Cancer: A Retrospective Study [0.03%]
奥西替尼联合铂类化疗治疗EGFR突变非小细胞肺癌的临床疗效研究：一项回顾性研究
Ruixue Han,Xin Yu
Ruixue Han
Objective: To assess the clinical outcomes of osimertinib combined with platinum-based chemotherapy in patients with epidermal growth factor receptor (EGFR)-mutant non-small cell lung cancer (NSCLC) and to describe associ...
Post-Translational Modifications of Histones and Non-Histones in Liver Disease and Traditional Chinese Medicine Treatment: A Narrative Review [0.03%]
肝病及中医药治疗中的组蛋白与非组蛋白的翻译后修饰：综述文章
Zhuohua Xie,Yanting Deng,Xinru Zhang et al.
Zhuohua Xie et al.
Post-translational modifications (PTMs) of histones and non-histones are significant epigenetic modifications in humans, including acetylation, methylation, phosphorylation, glycosylation, and ubiquitination. These modifications regulate ch...
NAT2 Acetylation Phenotypes in India: A Narrative Review of Personalized TB Therapy [0.03%]
印度 NAT2 乙酰化表型：个性化结核病治疗的叙述性综述
Nikhat Khan,Manjari Jonnalagadda,Ravindra Kumar et al.
Nikhat Khan et al.
Tuberculosis (TB) continues to be a significant health challenge in India, which necessitates accurate and personalized therapeutic strategies for its successful treatment. Polymorphisms in the N-acetyltransferase-2 (NAT2) enzyme, involved ...
Bioinformatic Identification and Preliminary Validation of TP53, TGFB1, and NFE2L2 as Potential Ferroptosis-Related Regulators in Pancreatic Adenocarcinoma [0.03%]
TP53、TGFB1和NFE2L2作为胰腺导管腺癌铁死亡相关调节因子的生物信息学鉴定及初步验证
Shouying Li,Chunfang Zhang,Shengxiang Lv et al.
Shouying Li et al.
Background: Pancreatic adenocarcinoma (PAAD) is a highly malignant tumor with very poor prognosis for patients. Ferroptosis, as a novel cell death mechanism, brings a new direction for PAAD therapeutic research. ...
Managing Refractory Hypertension: A Case Study Exploring the Influence of ACE and ACTN3 Gene Polymorphisms [0.03%]
难治性高血压的管理：一个探讨ACE和ACTN3基因多态性影响的病例研究
Benedikt Gasser,Alain Dössegger,Martin Flück
Benedikt Gasser
The responses to Antihypertensive drugs vary among patients. The renal and muscular processes of blood flow regulation in peripheral blood vessels depend on the genetic and physiological constitution. Here, we present a case of an elderly f...
Case Report: Successful Surgical Resection of PVTT Vp4 Hepatocellular Carcinoma Following Hepatic Arterial Infusion Chemotherapy Combined with Cadonilimab Plus Donafenib [0.03%]
个例报告：肝动脉灌注化疗联合卡度尼利单抗和多纳非尼治疗Vp4门静脉癌栓肝细胞癌的手术切除成功案例
Sizhi Chen,Yongguang Wei,Xiwen Liao et al.
Sizhi Chen et al.
Objective: To evaluate the potential and efficacy of hepatic artery infusion chemotherapy combined with the PD-1/CTLA-4 bispecific antibody cadonilimab and the multi-kinase inhibitor donafenib in conversion therapy for un...
Berberine Repairs Intestinal Mucosal Barrier by Targeting HSP90AA1 and MAPK14 [0.03%]
巴马汀通过靶向HSP90AA1和MAPK14修复肠道黏膜屏障功能
Danya Zhao,Yang Zhai,Chen Chen et al.
Danya Zhao et al.
Background: Berberine (BBR), a key compound in Coptis chinensis, has broad pharmacological properties, though its specific Crohn's disease (CD) targets and mechanisms are undefined. ...
Genetic Landscape of VIP Pharmacogenomic Variants in the Kinh Vietnamese Population [0.03%]
越南京族人群中VIP药物基因组变异的遗传谱系
Hang Tong,Vo Thu Nga Phan,Tu Nguyen et al.
Hang Tong et al.
Background: Genetic polymorphisms in the genes encoding enzymes and proteins in drug metabolism, transport, and response can significantly impact enzymatic activity and overall pharmacokinetics and pharmacodynamics, leadi...