Managing Refractory Hypertension: A Case Study Exploring the Influence of ACE and ACTN3 Gene Polymorphisms [0.03%]
难治性高血压的管理：一个探讨ACE和ACTN3基因多态性影响的病例研究
Benedikt Gasser,Alain Dössegger,Martin Flück
Benedikt Gasser
The responses to Antihypertensive drugs vary among patients. The renal and muscular processes of blood flow regulation in peripheral blood vessels depend on the genetic and physiological constitution. Here, we present a case of an elderly f...
Case Report: Successful Surgical Resection of PVTT Vp4 Hepatocellular Carcinoma Following Hepatic Arterial Infusion Chemotherapy Combined with Cadonilimab Plus Donafenib [0.03%]
个例报告：肝动脉灌注化疗联合卡度尼利单抗和多纳非尼治疗Vp4门静脉癌栓肝细胞癌的手术切除成功案例
Sizhi Chen,Yongguang Wei,Xiwen Liao et al.
Sizhi Chen et al.
Objective: To evaluate the potential and efficacy of hepatic artery infusion chemotherapy combined with the PD-1/CTLA-4 bispecific antibody cadonilimab and the multi-kinase inhibitor donafenib in conversion therapy for un...
Berberine Repairs Intestinal Mucosal Barrier by Targeting HSP90AA1 and MAPK14 [0.03%]
巴马汀通过靶向HSP90AA1和MAPK14修复肠道黏膜屏障功能
Danya Zhao,Yang Zhai,Chen Chen et al.
Danya Zhao et al.
Background: Berberine (BBR), a key compound in Coptis chinensis, has broad pharmacological properties, though its specific Crohn's disease (CD) targets and mechanisms are undefined. ...
Genetic Landscape of VIP Pharmacogenomic Variants in the Kinh Vietnamese Population [0.03%]
越南京族人群中VIP药物基因组变异的遗传谱系
Hang Tong,Vo Thu Nga Phan,Tu Nguyen et al.
Hang Tong et al.
Background: Genetic polymorphisms in the genes encoding enzymes and proteins in drug metabolism, transport, and response can significantly impact enzymatic activity and overall pharmacokinetics and pharmacodynamics, leadi...
Whole Exome Sequencing Reveals Novel Genetic Variants Associated with Atrial Septal Defect in a Tibetan Patient Cohort [0.03%]
全外显子组测序在藏族先天性房间隔缺损患者中鉴定出新的致病基因变异
Hongwei Li,Yongjun He,Zhengyao Cai et al.
Hongwei Li et al.
Objective: Atrial septal defect (ASD) is a common congenital heart defect with incompletely understood genetic underpinnings, particularly in specific ethnic groups. This study aimed to identify novel genetic variants rel...
Ulcerative Colitis: Advances in Pathogenesis, Biomarkers, and Therapeutic Strategies [0.03%]
溃疡性结肠炎：发病机制、生物标志物和治疗策略的新进展
Siyuan Bu,Xiaozhen Cheng,Meng Chen et al.
Siyuan Bu et al.
Ulcerative colitis represents an inflammatory bowel disease with multiple contributing factors, marked by persistent inflammation of the colonic mucosa, which can lead to a reduced life expectancy and an elevated likelihood of requiring col...
The Prevalence of Potential Drug-Drug-Gene Interactions: A Descriptive Study Using Swiss Claims Data [0.03%]
一项关于潜在药物-药物-基因相互作用流行率的描述性研究：利用瑞士医疗索赔数据进行分析
Nina L Wittwer,Christoph R Meier,Carola A Huber et al.
Nina L Wittwer et al.
Purpose: We aimed to determine the prevalence of interactions between PGx drugs metabolized by CYP2C9, CYP2C19, and CYP2D6 and drugs that act as inhibitors or inducers of those enzymes in the Swiss population. ...
Association Between ABCB1 Gene Polymorphism with Hyperglycemia and MACE in Patients Undergoing Clopidogrel Treatment After PCI [0.03%]
ABCB1基因多态性与氯吡格雷治疗后PCI患者高血糖及MACE的关系
Bo Zhou,Chuanshen Shi,Qike Xu et al.
Bo Zhou et al.
Purpose: To evaluate the effect of ABCB1 C3435T gene polymorphism with hyperglycemia on the risk of major adverse cardiovascular events (MACE) in patients treated with clopidogrel after percutaneous coronary intervention ...
Dual EGFR L858R and KRAS G12A Mutations in Lung Adenocarcinoma: A Rare Case Report and Literature Review [0.03%]
肺腺癌合并EGFR基因L858R突变和KRAS基因G12A突变罕见病例报告及文献复习
Gang Wei,Jun Tang,Huaiwen Wang et al.
Gang Wei et al.
Background: KRAS mutations are typically mutually exclusive in non-small cell lung cancer (NSCLC), with the G12C mutation being the most common subtype. The coexistence of KRAS and EGFR mutations is exceedingly rare and i...
Construction of a Nomogram Model for Predicting Prognosis in Breast Cancer Patients Based on the Expression of THRSP and ACACA Proteins Tissues [0.03%]
基于THRSP和ACACA蛋白表达构建乳腺癌患者预后预测 nomogram 模型及效能分析
Benkai Wei,Fan Li,Huanhuan Yan et al.
Benkai Wei et al.
Background: This study aimed to analyze the expression of thyroid hormone-responsive spot 14 (THRSP) and acetyl-CoA carboxylase alpha (ACACA) proteins in breast cancer tumor tissues and their relationship with clinicopath...