Severe Vincristine-Induced Peripheral Neuropathic Weakness in Both Lower Limbs in an Asian Adolescent with CYP3A4 rs2740574 TT Genotype [0.03%]
亚洲CYP3A4rs2740574TT基因型青少年 vincristine导致的双下肢严重外周神经病性肌无力病例报告
Dongdong Zhang,Jie Bai
Dongdong Zhang
Background: Vincristine (VCR)-induced peripheral neuropathy (VIPN) is a common adverse reaction during cancer treatment, typically characterized by numbness and paresthesias. This study aimed to report a rare case of VIPN...
Identification of a Novel Mitochondrial tRNA Mutation in Chinese Family with Type 2 Diabetes Mellitus [0.03%]
中国人线粒体tRNA新型突变与二型糖尿病关系的研究
Xing Li,Jinyao Shang,Shuang Li et al.
Xing Li et al.
Background: Mutations in mitochondrial tRNA (mt-tRNA) could be the origin of some type 2 diabetes mellitus (T2DM) cases, but the mechanism remained largely unknown. ...
Identification of Lower Grade Glioma Antigens Based on Ferroptosis Status for mRNA Vaccine Development [0.03%]
基于铁死亡状态的低级别胶质瘤抗原鉴定用于mRNA疫苗开发
Zhenxiang Zhao,Na Xing,Hao Guo et al.
Zhenxiang Zhao et al.
Purpose: mRNA vaccines represent a promising and innovative strategy within the realm of cancer immunotherapy. However, their efficacy in treating lower-grade glioma (LGG) requires evaluation. Ferroptosis exhibits close a...
Exploration of the Correlation Between GRHL1 Expression and Tumor Microenvironment in Endometrial Cancer and Immunotherapy [0.03%]
GRHL1表达与子宫内膜癌肿瘤微环境及免疫治疗的相关性探究
Suyang Guo,Wenqi Bai,Fengjie Cui et al.
Suyang Guo et al.
Introduction: GRHL1 belongs to the family of Grainyhead-like (GRHL). Previous studies have shown that dysregulation of growth and survival pathways is associated with the GRHL family of gene cancers. Immunotherapy with ch...
The Association Between Mitochondrial tRNAGlu Variants and Hearing Loss: A Case-Control Study [0.03%]
线粒体tRNAGlu基因多态性与耳聋的相关性研究
Xuejiao Yu,Sheng Li,Qinxian Guo et al.
Xuejiao Yu et al.
Purpose: This study aimed to examine the frequencies of mt-tRNAGlu variants in 180 pediatric patients with non-syndromic hearing loss (NSHL) and 100 controls. ...
Natural Language Processing for Radiation Oncology: Personalizing Treatment Pathways [0.03%]
放射肿瘤学中的自然语言处理：个性化治疗路径
Hui Lin,Lisa Ni,Christina Phuong et al.
Hui Lin et al.
Natural language processing (NLP), a technology that translates human language into machine-readable data, is revolutionizing numerous sectors, including cancer care. This review outlines the evolution of NLP and its potential for crafting ...
Pharmacogenomic Analysis of CYP3A5*3 and Tacrolimus Trough Concentrations in Vietnamese Renal Transplant Outcomes [0.03%]
CYP3A5*3基因与越南肾移植患者他克莫司的血药浓度 Pharmacogenomic分析
Thi Van Anh Nguyen,Ba Hai Le,Minh Thanh Nguyen et al.
Thi Van Anh Nguyen et al.
Purpose: CYP3A5 polymorphisms have been associated with variations in the pharmacokinetics of tacrolimus (Tac) in kidney transplant patients. Our study aims to quantify how the CYP3A5 genotype influences tacrolimus trough...
Response to: "Challenges in DPYD Test Implementation in Patients Treated with Fluoropyirimidines, is DPYD Genotype Arriving on Time?" [Response to Letter] [0.03%]
对“用氟吡啶嘧啶治疗的DPYD检测实施中遇到的问题是患者的DPYD基因型测试结果及时出来了吗？”[回复信件]
Cristina Montrasio,Stefania Cheli,Emilio Clementi
Cristina Montrasio
The Impact of Opioid Receptor Gene Polymorphism on Fentanyl and Alfentanil's Analgesic Effects in the Pediatric Perioperative Period [0.03%]
阿片受体基因多态性对儿童围手术期芬太尼和阿尔法芬太尼镇痛效果的影响
Jelena Lilic,Vesna G Marjanovic,Ivana Budic et al.
Jelena Lilic et al.
Introduction: The polymorphism of the gene coding mu-opioid receptor (OPRM1) is one of the factors contributing to the variability in the response to opioid analgesics in children. The goal of this study is to investigate...
FBLN5 as One Presumably Prognostic Gene Potentially Modulating Tumor Immune Microenvironment for Renal Clear Cell Carcinoma in Children and Young Adults [0.03%]
FBLN5可能是影响儿童和青少年轻型肾细胞癌肿瘤免疫微环境的一个预后基因
Ming Zhang,Feng Chen,Shaoguang Feng et al.
Ming Zhang et al.
Objective: To investigate the role of FBLN5in renal clear cell carcinoma (KIRC), in particular on the tumor's immune microenvironment, including children and young adults. ...