Pharmacogenomics in type II diabetes mellitus management: Steps toward personalized medicine [0.03%]
糖尿病二期药物基因组学：迈向个性化医疗的一步
Peter Avery,Shaymaa S Mousa,Shaker A Mousa
Peter Avery
Advances in genotype technology in the last decade have put the pharmacogenomics revolution at the forefront of future medicine in clinical practice. Discovery of novel gene variations in drug transporters, drug targets, effector proteins a...
Pharmacogenomics in osteoporosis: Steps toward personalized medicine [0.03%]
骨质疏松症的药物基因组学：迈向个性化医疗的第一步
Robert Greene,Shaymaa S Mousa,Mohamed Ardawi et al.
Robert Greene et al.
Osteoporosis is a complicated and preventable disease with major morbidity complications that affects millions of people. In the last 15 years, there have been numerous studies and research in the new fields of pharmacogenetics and pharmaco...
Pharmacogenomics in cardiovascular disorders: Steps in approaching personalized medicine in cardiovascular medicine [0.03%]
心血管疾病用药基因组学：心血管医学个性化医疗的实现步骤
Christopher Barone,Shaymaa S Mousa,Shaker A Mousa
Christopher Barone
Some of the most commonly prescribed medications are those for cardiovascular maladies. The beneficial effects of these medications have been well documented. However, there can be substantial variation in response to these medications amon...
Influence of socioeconomic lifestyle factors and genetic polymorphism on type 2 diabetes occurrences among Tunisian Arab and Berber groups of Djerba Island [0.03%]
突尼斯塔尔巴岛阿拉伯人和柏柏尔人群体中社会经济生活方式因素及基因多态性对2型糖尿病发生率的影响
Thouraya Baroudi Ouederni,Ahmed Fadiel,Nejla Stambouli et al.
Thouraya Baroudi Ouederni et al.
Type 2 diabetes mellitus (T2DM) is characterized by three major metabolic abnormalities: impaired insulin-stimulated glucose uptake in muscle and adipose tissues, alterations in glucose-stimulated insulin secretion, and increased hepatic gl...
Wolfgang Hueber,William H Robinson
Wolfgang Hueber
Tremendous progress has been made over the past decade in the development and refinement of genomic and proteomic technologies for the identification of novel drug targets and molecular signatures associated with clinically important diseas...
Tailoring treatment of nonsmall cell lung cancer by tissue type: role of pemetrexed [0.03%]
组织类型介导的非小细胞肺癌治疗个体化——培美曲塞的作用
Steven F Powell,Arkadiusz Z Dudek
Steven F Powell
Pemetrexed (ALIMTA, LY231514, MTA) is a novel multitargeted antifolate that is currently approved for the treatment of metastatic nonsmall cell lung cancer (NSCLC). Recent evidence reveals that the drug's efficacy is limited to nonsquamous ...
Lack of association between the A118G polymorphism of the mu opioid receptor gene (OPRM1) and opioid dependence: A meta-analysis [0.03%]
μ-阿片受体基因(OPRM1)A118G多态性与阿片类物质依赖无相关性的meta分析
Janet K Coller,Julia Beardsley,James Bignold et al.
Janet K Coller et al.
Mu opioid receptor (OPRM1) gene variants, particularly the common A118G single nucleotide polymorphism (SNP), are among the most frequently studied candidate genes associated with opioid dependence. However, despite numerous case-control st...
Pharmacogenomic application of the haptoglobin genotype in the treatment of HDL dysfunction [0.03%]
应用APOA1基因多态性指导血脂异常患者个性化治疗以改善HDL功能研究
Avery Schwartz,Shany Blum,Rabea Asleh et al.
Avery Schwartz et al.
An emerging paradigm of research has suggested that in the setting of diabetes mellitus (DM) the quality or function of high-density lipoprotein (HDL) may be a determinant of cardiovascular disease risk. Specific structural modifications of...
Association study of a brain-derived neurotrophic-factor polymorphism and short-term antidepressant response in major depressive disorders [0.03%]
脑源性神经营养因子多态性和抑郁症短期抗抑郁疗效的关联研究
Eugene Lin,Po See Chen,Lung-Cheng Huang et al.
Eugene Lin et al.
Major depressive disorder (MDD) is one of the most common mental disorders worldwide. Single nucleotide polymorphisms (SNPs) can be used in clinical association studies to determine the contribution of genes to drug efficacy. A common SNP i...
Sulfation of fulvestrant by human liver cytosols and recombinant SULT1A1 and SULT1E1 [0.03%]
人肝胞浆和重组SULT1A1及SULT1E1对氟维司群硫酸化的催化作用
Vineetha Koroth Edavana,Xinfeng Yu,Ishwori B Dhakal et al.
Vineetha Koroth Edavana et al.
Fulvestrant (Faslodex™) is a pure antiestrogen that is approved to treat hormone receptor-positive metastatic breast cancer in postmenopausal women. Previous studies have demonstrated that fulvestrant metabolism in humans involves cytochro...