Clinical application of high throughput molecular screening techniques for pharmacogenomics [0.03%]
高通量分子筛选技术在药物基因组学临床应用中的作用
Arun P Wiita,Iris Schrijver
Arun P Wiita
Genetic analysis is one of the fastest-growing areas of clinical diagnostics. Fortunately, as our knowledge of clinically relevant genetic variants rapidly expands, so does our ability to detect these variants in patient samples. Increasing...
Clinical implementation of RNA signatures for pharmacogenomic decision-making [0.03%]
临床实施RNA标志物用于药物基因组决策分析
Weihua Tang,Zhiyuan Hu,Hind Muallem et al.
Weihua Tang et al.
RNA profiling is increasingly used to predict drug response, dose, or toxicity based on analysis of drug pharmacokinetic or pharmacodynamic pathways. Before implementing multiplexed RNA arrays in clinical practice, validation studies are ca...
Role of 5-HT(2C) receptor gene variants in antipsychotic-induced weight gain [0.03%]
五-羟色胺2C受体基因多态性与抗精神病药物所致体重增加的关系
Tessa Jm Wallace,Clement C Zai,Eva J Brandl et al.
Tessa Jm Wallace et al.
Antipsychotic-induced weight gain is a serious side effect of antipsychotic medication that can lead to increased morbidity, mortality, and non-compliance in patients. Numerous single nucleotide polymorphisms have been studied for associati...
Antidepressant-induced akathisia-related homicides associated with diminishing mutations in metabolizing genes of the CYP450 family [0.03%]
抗抑郁药物引起的坐立不安相关的致死率下降与CYP450族代谢基因的削弱型突变有关
Yolande Lucire,Christopher Crotty
Yolande Lucire
Purpose: To examine the relation between variant alleles in 3 CYP450 genes (CYP2D6, CYP2C9 and CYP2C19), interacting drugs and akathisia in subjects referred to a forensic psychiatry practice in Sydney, Australia. ...
Alec Vaezi,Chelsea H Feldman,Laura J Niedernhofer
Alec Vaezi
Advanced stage non-small cell lung cancer and head and neck squamous cell carcinoma are both treated with DNA damaging agents including platinum-based compounds and radiation therapy. However, at least one quarter of all tumors are resistan...
A genetic approach to the prediction of drug side effects: bleomycin induces concordant phenotypes in mice of the collaborative cross [0.03%]
遗传方法预测药物副作用：博来霉素使协作交叉小鼠品种产生一致的表型反应
Richard Gelinas,Elissa J Chesler,Daphne Vasconcelos et al.
Richard Gelinas et al.
The antineoplastic drug bleomycin leads to the side effect of pulmonary fibrosis in both humans and mice. We challenged genetically diverse inbred lines of mice from the Collaborative Cross with bleomycin to determine the heritability of th...
Pharmacogenomics of drug metabolizing enzymes and transporters: implications for cancer therapy [0.03%]
药物代谢酶和转运体的药理基因组学在癌症治疗中的应用
Jing Li,Martin H Bluth
Jing Li
The new era of personalized medicine, which integrates the uniqueness of an individual with respect to the pharmacokinetics and pharmacodynamics of a drug, holds promise as a means to provide greater safety and efficacy in drug design and d...
Optimizing response to gefitinib in the treatment of non-small-cell lung cancer [0.03%]
吉非替尼治疗非小细胞肺癌反应性的优化措施
Pietro Carotenuto,Cristin Roma,Anna Maria Rachiglio et al.
Pietro Carotenuto et al.
The epidermal growth factor receptor (EGFR) is expressed in the majority of non-small-cell lung cancer (NSCLC). However, only a restricted subgroup of NSCLC patients respond to treatment with the EGFR tyrosine kinase inhibitor (EGFR TKI) ge...
The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations underlying neonatal diabetes [0.03%]
ATP敏感性钾通道基因突变在新生儿糖尿病中的分子机制及药物治疗学
Veronica Lang,Peter E Light
Veronica Lang
Neonatal diabetes mellitus (NDM) is a monogenic disorder caused by mutations in genes involved in regulation of insulin secretion from pancreatic β-cells. Mutations in the KCNJ11 and ABCC8 genes, encoding the adenosine triphosphate (ATP)-s...
Pharmacogenetics in breast cancer: steps toward personalized medicine in breast cancer management [0.03%]
乳腺癌的药物基因组学：迈向个性化的乳腺癌治疗步骤
Sarah Rofaiel,Esther N Muo,Shaker A Mousa
Sarah Rofaiel
There is wide individual variability in the pharmacokinetics, pharmacodynamics, and tolerance to anticancer drugs within the same ethnic group and even greater variability among different ethnicities. Pharmacogenomics (PG) has the potential...