Targeted treatment of folate receptor-positive platinum-resistant ovarian cancer and companion diagnostics, with specific focus on vintafolide and etarfolatide [0.03%]
叶酸受体阳性铂耐药性卵巢癌的靶向治疗及伴随诊断，重点关注vintafolide和etarfolatide
Loredana Serpe,Margherita Gallicchio,Roberto Canaparo et al.
Loredana Serpe et al.
Among the gynecological malignancies, ovarian cancer is the leading cause of mortality in developed countries. Treatment of ovarian cancer is based on surgery integrated with chemotherapy. Platinum-based drugs (cisplatin and carboplatin) co...
Radhika Kainthla,Kevin B Kim,Gerald S Falchook
Radhika Kainthla
Melanoma has the highest mortality of all the skin cancer subtypes. Historically, chemotherapy and immunologic therapies have yielded only modest results in the treatment of metastatic melanoma. The discovery of prevalent V600 BRAF mutation...
Overview of diagnostic/targeted treatment combinations in personalized medicine for breast cancer patients [0.03%]
乳腺癌患者个性化医疗中的诊断和靶向治疗组合概述
Anna Tessari,Dario Palmieri,Serena Di Cosimo
Anna Tessari
Breast cancer includes a body of molecularly distinct subgroups, characterized by different presentation, prognosis, and sensitivity to treatments. Significant advances in our understanding of the complex architecture of this pathology have...
Patient selection and targeted treatment in the management of platinum-resistant ovarian cancer [0.03%]
铂耐药性卵巢癌的患者选择和靶向治疗
Christopher P Leamon,Chandra D Lovejoy,Binh Nguyen
Christopher P Leamon
Ovarian cancer (OC) has the highest mortality rate of any gynecologic cancer, and patients generally have a poor prognosis due to high chemotherapy resistance and late stage disease diagnosis. Platinum-resistant OC can be treated with cytot...
Rachel Mills,Deepak Voora,Bruce Peyser et al.
Rachel Mills et al.
Pharmacogenetic testing refers to a type of genetic test to predict a patient's likelihood to experience an adverse event or not respond to a given drug. Despite revision to several labels of commonly prescribed drugs regarding the impact o...
Lack of correlation between in silico projection of function and quantitative real-time PCR-determined gene expression levels in colon tissue [0.03%]
结肠组织中基于计算的功能预测与定量实时PCR测定的基因表达量之间的不相关性研究
Rosalind B Penney,Abbie Lundgreen,Aiwei Yao-Borengasser et al.
Rosalind B Penney et al.
There are a number of in silico programs that use algorithms and external web sources to predict the effect of single nucleotide polymorphisms (SNPs). While many of these programs have been shown to predict accurately the effect of SNPs in ...
Association of CYP3A4/5, ABCB1 and ABCC2 polymorphisms and clinical outcomes of Thai breast cancer patients treated with tamoxifen [0.03%]
CYP3A4/5、ABCB1和ABCC2多态性与泰国乳腺癌患者他莫西芬治疗临床结局的相关性分析
Insee Sensorn,Ekaphop Sirachainan,Montri Chamnanphon et al.
Insee Sensorn et al.
Background: Pharmacogenetic study of cytochrome P450 (CYP) gene CYP2D6 and tamoxifen outcomes remain controversial. Apart from CYP2D6, other drug-metabolizing enzymes and transporters also play a role in tamoxifen metabol...
CYP2C19 polymorphisms in the Thai population and the clinical response to clopidogrel in patients with atherothrombotic-risk factors [0.03%]
泰国人血小板糖蛋白受体CPY2C19多态性与脑卒中患者氯吡格雷临床反应的关系研究
Chonlaphat Sukasem,Ramaimon Tunthong,Montri Chamnanphon et al.
Chonlaphat Sukasem et al.
Genetic variation in the cytochrome P450 2C19 (CYP2C19) gene has been documented gradually as the determinant conversion and variability in the antiplatelet effect of clopidogrel. The aims of this study were to determine the prevalence of c...
Role of biomarkers in understanding and treating children with asthma: towards personalized care [0.03%]
生物标志物在儿童哮喘诊疗中的作用：迈向个性化治疗
Jason E Lang,Kathryn V Blake
Jason E Lang
Asthma is one of the most common chronic diseases affecting children. Despite publicized expert panels on asthma management and the availability of high-potency inhaled corticosteroids, asthma continues to pose an enormous burden on quality...
ABCB1 haplotypes do not influence transport or efficacy of tyrosine kinase inhibitors in vitro [0.03%]
ABCB1基因型未影响ABL酪氨酸激酶抑制剂的体外转运及活性
Karin Skoglund,Samuel Boiso Moreno,Maria Baytar et al.
Karin Skoglund et al.
Single-nucleotide polymorphisms (SNPs) in the gene coding for the efflux-transport protein ABCB1 (P-glycoprotein) are commonly inherited as haplotypes. ABCB1 SNPs and haplotypes have been suggested to influence the pharmacokinetics and ther...