Hsa_circ_0003489 Drives PTX Resistance of Human NSCLC Cells Through Modulating miR-98-5p/IGF2 [0.03%]
Hsa_circ_0003489通过调控miR-98-5p/IGF2诱导人NSCLC细胞对PTX产生抗性
Shaofeng Xia,Chenliang Wang
Shaofeng Xia
Background: Circular RNAs (circRNAs) demonstrated critical roles within developing tumors and treatment resistance in an increasing body of research. The aim was to look into the functions and processes of hsa_circ_000348...
Pyroptosis and Inflammasome-Related Genes- NLRP3, NLRC4 and NLRP7 Polymorphisms Were Associated with Risk of Lung Cancer [0.03%]
肺腺癌发病与焦亡及相关炎症小体基因NLRP3、NLRC4和NLRP7多态性的关联性研究
Xin Jing,Yuhui Yun,Xiang Ji et al.
Xin Jing et al.
Background: Cancer development and tumor immune microenvironment remodeling are closely linked to pyroptosis and inflammasome activation. However, little information is available in single nucleotide polymorphisms (SNPs) ...
A Case-Control Study of the Relationship Between Genetic Polymorphism and Cretinism in Xinjiang [0.03%]
新疆地方性克汀病的遗传因素病例对照研究
Jia Huang,Haiyan Wu,Guiqiang Zhao et al.
Jia Huang et al.
Background: Cretinism is a subtype of congenital hypothyroidism, an endocrine disorder resulting from inadequate thyroid hormone production or receptor deficiency. Genetic abnormalities play a major role in the developmen...
Clinical Characteristics and Novel ZEB2 Gene Mutation Analysis of Three Chinese Patients with Mowat-Wilson Syndrome [0.03%]
三例Mowat-Wilson综合征中国患者的临床特征及ZEB2新突变分析
Xiao Han,Qianjuan Zhang,Chengcheng Wang et al.
Xiao Han et al.
Purpose: Mowat-Wilson syndrome (MWS) is an autosomal dominant disease caused by a pathogenic variant of the ZEB2 gene. The main clinical manifestations include special facial features, Hirschsprung disease (HSCR), global ...
Identification of Two Novel Variants of the DMD Gene in Chinese Families with Duchenne Muscular Dystrophy [0.03%]
DMD基因两种新变异在进行性肌营养不良症患者中的鉴定
Jiangfen Wu,Lingyan Ren,Xinyi Huang et al.
Jiangfen Wu et al.
Background: Duchenne muscular dystrophy (DMD), an X-linked recessive neuromuscular disorder, is caused by pathogenic variants in the DMD gene encoding a large structural protein in muscle cells. ...
A Case Study and Literature Review of the Diagnosis of Danon Disease in Patients Presenting Only with Severe Cardiac Symptoms [0.03%]
丹东病只表现为严重心脏症状的诊断案例研究与文献回顾
Yu-Qing Sun,Qiang Lv,Dong Chen et al.
Yu-Qing Sun et al.
The clinical manifestations of Danon disease, which result from the primary deficiency of the lysosome-associated membrane protein 2 gene, include cardiomyopathy, skeletal myopathy, and different degrees of intellectual disability that vary...
PSMC2 is a Novel Prognostic Biomarker and Predicts Immunotherapeutic Responses: From Pancreatic Cancer to Pan-Cancer [0.03%]
PSMC2是一个新的预后生物标志物并可预测免疫治疗反应：从胰腺癌到泛癌分析
Wei Huang,Zhengtao Qian,Yuxin Shi et al.
Wei Huang et al.
Background: Proteasome 26S subunit ATPase 2 (PSMC2) is a part of the 19S regulatory complex, which catalyzes the unfolding and transport of substrates into the 20S proteasome. Our previous research demonstrated that PSMC2...
Pharmacogenetic Practice of Anticancer Drugs: Multiple Approaches for an Accurate and Comprehensive Genotyping [0.03%]
抗癌药物的药妆实践：准确全面基因分型的多种方法
Cristina Montrasio,Stefania Cheli,Emilio Clementi
Cristina Montrasio
The application of pharmacogenetics in oncology is part of the routine clinical practice. In particular, genotyping of dihydropyrimidine dehydrogenase (DPYD) and UDP-glucuronosyltransferase (UGT1A1) is crucial to manage the treatment of pat...
Pharmacogenomics in the Management of Pulmonary Arterial Hypertension: Current Perspectives [0.03%]
肺动脉高压管理中的药物基因组学：当前观点
James C Coons,Philip E Empey
James C Coons
Pulmonary arterial hypertension (PAH) is a rare disease with heterogeneous causes that can lead to right ventricular (RV) failure and death if left untreated. There are currently 10 medications representative of five unique pharmacologic cl...
Association Between HTRA1, GAS6 and IFNGR2 Gene Polymorphisms and Stroke Susceptibility in the Chinese Han Population [0.03%]
汉族人群中HTRA1、GAS6和IFNGR2基因多态性与卒中易感性的关联研究
Fan Zhang,Hao Peng,Chuanyi Fu et al.
Fan Zhang et al.
Background: Stroke has a high disability rate, and 30% of stroke cases have an unknown cause. Accurate diagnosis and treatment of stroke requires consideration of several rare heritable and non-heritable factors. ...