Therapeutic Potential of Moringa oleifera in Alzheimer's Disease: A Review of Neuroprotective Mechanisms [0.03%]
辣木对阿尔茨海默病的治疗潜力：神经保护机制综述
Hui Yu,Adeel Ahmed Abbasi,Hamid Khan et al.
Hui Yu et al.
Alzheimer's disease (AD) is characterized by features such as progressive cognitive decline, memory loss, and tau hyperphosphorylation, all of which are observed in Alzheimer's disease. Moringa contains phytochemicals, including flavonoids ...
Treatment Approaches for Omalizumab-Refractory Chronic Spontaneous Urticaria [0.03%]
奥马珠单抗耐药的慢性自发性荨麻疹的治疗方案
Luis Felipe Ensina,Marta Ferrer,Mona Al-Ahmad et al.
Luis Felipe Ensina et al.
Chronic spontaneous urticaria (CSU) is a mast cell-driven disease that impairs health-related quality of life. Although omalizumab is a cornerstone treatment for patients uncontrolled with up-dosed second-generation H1-antihistamines, some ...
Platelet-to-White Blood Cell Ratio as a Predictor of ICU Mortality in Septic Shock and Heart Failure: A Real-World Validation Study Using the MIMIC-eICU and a Chinese Cohort [0.03%]
血小板/白细胞比值对脓毒症和心衰患者ICU病死率的预测价值：来自MIMIC-eICU及中国人群的实证验证研究
Qianfei Liu,Weihua Tang,Wei Tan et al.
Qianfei Liu et al.
Background: The platelet-to-white blood cell ratio (PWR) has been associated with adverse outcomes in critically ill patients. Nonetheless, its prognostic significance in individuals with concurrent septic shock and heart...
Salvianic Acid A Regulates Ferroptosis by Activating the Nrf2-GPX4 Pathway Through EGFR to Protect Myocardial Ischemia-Reperfusion Injury [0.03%]
salvianic酸A通过EGFR激活Nrf2-GPX4信号通路调节铁死亡以保护心肌缺血再灌注损伤
Lin Tu,Yuming Lu,Xingde Liu et al.
Lin Tu et al.
Objective: Salvianic acid A, known for its potent cardioprotective effects, is a promising therapeutic agent for myocardial ischemia-reperfusion (I/R) injury, a condition where ferroptosis plays a critical role. This stud...
Short-Chain Fatty Acids: A Key Modulator of Sepsis-Associated Acute Respiratory Distress Syndrome [0.03%]
短链脂肪酸：脓毒症相关急性呼吸窘迫综合征的关键调节因子
Yuting Sun,Meilin He,Jiaqi Li et al.
Yuting Sun et al.
Sepsis-associated acute respiratory distress syndrome (ARDS) is a common clinical fatal complication, and intestinal flora imbalance has been proved to be a key link in the mechanism of morbidity. Intestinal dysbacteriosis directly contribu...
Tocilizumab Treatment in Refractory Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Case Report and Literature Review [0.03%]
托珠单抗治疗难治性自身免疫性胶质纤维酸性蛋白天疱疮的疗效：1例报告及文献复习
Xueqin Lin,Shichen Zhou,Zhanwei Zhang et al.
Xueqin Lin et al.
Although most patients with autoimmune glial fibrillary acidic protein astrocytopathy (GFAP-A) respond to first-line immunotherapy, a subset is refractory to conventional treatments and experiences poor outcomes. This study evaluates the ef...
Guilu Erxian Glue Restores Immune Homeostasis in Aplastic Anemia Mice by Regulating Treg Lineage Stability via the miRNA-17/10a and FasL/Fas Signaling Pathways [0.03%]
归脾二仙胶通过miRNA-17/10a和FasL/Fas信号通路调控Treg稳态重建免疫平衡治疗再生障碍性贫血小鼠
Song Sun,Boyang Meng,Jinghao Sang et al.
Song Sun et al.
Background: This study investigates the functional role and mechanisms of Guilu Erxian Glue (GEG) in regulating immune homeostasis to treat bone marrow (BM) failure in aplastic anemia (AA). ...
Remodeling of Cardiac Macrophage Subsets Serves as a Critical Driver of Early Diabetic Myocardial Injury [0.03%]
心肌病灶型巨噬细胞亚群的重塑是糖尿病早期心肌损伤的关键驱动因素
Kun Xu,Ying-Min Zhang,Lan Yang et al.
Kun Xu et al.
Background: Diabetic cardiomyopathy (DCM) is a major complication of diabetes; however, the mechanisms underlying cardiac immune microenvironment dysregulation in early DCM remain to be systematically elucidated. ...
Mucosal Involvement in Bullous Pemphigoid: Severity Indicator and Associated Clinical Features from a Retrospective Cohort Study [0.03%]
有关大疱性 pemphigoid 粘膜受累严重程度指标和相关临床特征的回顾队列研究
Shengnan Cui,Bingjie Zhang,Fangyuan Chen et al.
Shengnan Cui et al.
Purpose: Bullous pemphigoid (BP) is the most common autoimmune subepidermal blistering disorder. Although mucosal involvement is uncommon, it may indicate a more severe clinical phenotype. This study evaluated the prevale...
Bidirectional Communication of the Gut-Brain Axis in Pain Regulation: From Microbial Metabolites to Neuroinflammation [0.03%]
肠-脑轴在疼痛调节中的双向通讯：从微生物代谢物到神经炎症
Zhouyi Song,Kai Zhou,Guangda Liang et al.
Zhouyi Song et al.
Chronic pain is increasingly recognized not merely as a physiological symptom of tissue damage, but as a multidimensional pathological state involving sensory, emotional, and cognitive components. Central to its modulation is the gut-brain ...