A Novel Rat Model to Simulate the Benign Esophageal Stricture Induced by Endoscopic Submucosal Dissection [0.03%]
模拟内镜粘膜下剥离术后良性食管狭窄的新大鼠模型
Yin-Gen Luo,Xiao-Wu Zhang,He Zhao et al.
Yin-Gen Luo et al.
Objective: This study aimed to establish a rat model that simulates benign esophageal strictures induced by endoscopic submucosal dissection (ESD). Materi...
Endoscopic-Assisted Percutaneous Sigmoidopexy: New Highlights on Technique and Outcomes [0.03%]
内镜辅助经皮乙状结肠固定术：技术与疗效的新亮点
Abdel Rahman A Al Manasra,Tarik Alhmoud,Zaid Mesmar et al.
Abdel Rahman A Al Manasra et al.
Background: Sigmoid volvulus is primarily a disease of the elderly. Case presentation: We describe a case of recurrent sigmoid volvulus...
Relevance of Procalcitonin Levels as a Marker of Severity and Predictor of Mortality, Initiation and Duration of Antibiotics in Patients Admitted with Acute Pancreatitis: A Retrospective Cohort Study [0.03%]
降钙素原水平作为急性胰腺炎患者病情严重程度和死亡率的标志物及预测抗生素使用期限的回顾性队列研究
Baldeep Kaur Mann,Janpreet Singh Bhandohal,Ishaan Kalha et al.
Baldeep Kaur Mann et al.
Introduction: Procalcitonin levels have been studied to predict the benefit of adding antibiotics in a patient with acute pancreatitis. Through this study, we are searching for any possible correlation between serum proca...
Magnetic Resonance Enterography Assessment of Transmural Healing with Vedolizumab in Moderate to Severe Crohn's Disease: Feasibility in the VERSIFY Phase 3 Clinical Trial [0.03%]
维多利珠单抗在中重度克罗恩病中的透壁性愈合的磁共振小肠显像评估：VERSIFY III期临床试验中的可行性研究
Jordi Rimola,Jean-Frédéric Colombel,Brian Bressler et al.
Jordi Rimola et al.
Purpose: The VERSIFY phase 3 trial in patients with Crohn's disease (CD) treated with vedolizumab was the first to include a substudy that used a standardized magnetic resonance enterography (MRE) protocol to assess featu...
Obstacles to Early Diagnosis of Acute Hepatic Porphyria: Current Perspectives on Improving Early Diagnosis and Clinical Management [0.03%]
急性肝卟啉病早期诊断的障碍：改善早期诊断和临床管理的当前观点
Manish Thapar,Akash Singh,Kevin M Robinson et al.
Manish Thapar et al.
Porphyrias are, for the most part, inherited disorders of the heme biosynthetic pathway which lead to accumulation of specific intermediates responsible for most of the symptoms and signs of biochemically active disease. Acute hepatic porph...
Development of a Pharmacokinetic Model That Accounts for the Plasma Concentrations of Conjugated and Unconjugated Bilirubin Observed in a Variety of Disease States [0.03%]
开发一种药代动力学模型来解释各种疾病状态下所观察到的结合和未结合胆红素的血浆浓度变化
David G Levitt,Michael D Levitt
David G Levitt
Introduction: For a large variety of liver pathologies, the plasma unconjugated (UB) and conjugated (CB) bilirubin concentrations appear to be coupled. For example, in alcoholic cirrhosis, UB and CB are roughly the same o...
Personalized Treatment for Crohn's Disease: Current Approaches and Future Directions [0.03%]
克罗恩病的个性化治疗：当前方法与未来方向
Joseph William Clinton,Raymond Keith Cross
Joseph William Clinton
Crohn's disease is a complex, relapsing and remitting inflammatory disorder of the gastrointestinal tract with a variable disease course. While the treatment options for Crohn's disease have dramatically increased over the past two decades,...
PSMA-Targeted PET Radiotracer [18F]DCFPyL as an Imaging Biomarker in Inflammatory Bowel Disease [0.03%]
用于炎症性肠病的PSMA靶向PET放射示踪剂[18F]DCFPyL作为影像学生物标志物
Mohamed Saleh Ismail,Diane E Peters,Steven P Rowe et al.
Mohamed Saleh Ismail et al.
Background: Prostate-specific membrane antigen (PSMA) is highly and specifically upregulated in active-inflamed mucosa of patients with inflammatory bowel disease (IBD). We hypothesized that this upregulation would be det...
Gardenia Iridoid Glucosides Protect Against α-Naphthalene Isothiocya-Nate-Induced Cholestatic Rats Through Activation of the FXR-SHP Signaling Pathway [0.03%]
白花丹参素通过激活FXR-SHP信号通路保护α-萘异硫氰酸盐诱导的胆汁淤积大鼠肝脏损伤
Meng Xu,Ke Che,Cong Wang et al.
Meng Xu et al.
Introduction: Cholestasis is a common liver disorder that currently has limited treatment options. Gardenia Iridoid Glucosides (GIG) have been found to possess various physiological activities, such as cholagogic, hypogly...
Body Mass Index Profile of Adult Patients with Inflammatory Bowel Disease in a Multicenter Study in Northeastern Brazil [0.03%]
巴西东北部多中心炎症性肠病成人患者体质指数分析
Jones Silva Lima,Carlos Alexandre Antunes de Brito,Lívia Medeiros Soares Celani et al.
Jones Silva Lima et al.
Purpose: Inflammatory bowel disease (IBD) is a disease of increasing prevalence in developing countries. Obesity has emerged as a potential risk for IBD; however, the data in the literature are conflicting, and relevant s...