Magnetic Resonance Enterography Assessment of Transmural Healing with Vedolizumab in Moderate to Severe Crohn's Disease: Feasibility in the VERSIFY Phase 3 Clinical Trial [0.03%]
维多利珠单抗在中重度克罗恩病中的透壁性愈合的磁共振小肠显像评估：VERSIFY III期临床试验中的可行性研究
Jordi Rimola,Jean-Frédéric Colombel,Brian Bressler et al.
Jordi Rimola et al.
Purpose: The VERSIFY phase 3 trial in patients with Crohn's disease (CD) treated with vedolizumab was the first to include a substudy that used a standardized magnetic resonance enterography (MRE) protocol to assess featu...
Obstacles to Early Diagnosis of Acute Hepatic Porphyria: Current Perspectives on Improving Early Diagnosis and Clinical Management [0.03%]
急性肝卟啉病早期诊断的障碍：改善早期诊断和临床管理的当前观点
Manish Thapar,Akash Singh,Kevin M Robinson et al.
Manish Thapar et al.
Porphyrias are, for the most part, inherited disorders of the heme biosynthetic pathway which lead to accumulation of specific intermediates responsible for most of the symptoms and signs of biochemically active disease. Acute hepatic porph...
Development of a Pharmacokinetic Model That Accounts for the Plasma Concentrations of Conjugated and Unconjugated Bilirubin Observed in a Variety of Disease States [0.03%]
开发一种药代动力学模型来解释各种疾病状态下所观察到的结合和未结合胆红素的血浆浓度变化
David G Levitt,Michael D Levitt
David G Levitt
Introduction: For a large variety of liver pathologies, the plasma unconjugated (UB) and conjugated (CB) bilirubin concentrations appear to be coupled. For example, in alcoholic cirrhosis, UB and CB are roughly the same o...
Personalized Treatment for Crohn's Disease: Current Approaches and Future Directions [0.03%]
克罗恩病的个性化治疗：当前方法与未来方向
Joseph William Clinton,Raymond Keith Cross
Joseph William Clinton
Crohn's disease is a complex, relapsing and remitting inflammatory disorder of the gastrointestinal tract with a variable disease course. While the treatment options for Crohn's disease have dramatically increased over the past two decades,...
PSMA-Targeted PET Radiotracer [18F]DCFPyL as an Imaging Biomarker in Inflammatory Bowel Disease [0.03%]
用于炎症性肠病的PSMA靶向PET放射示踪剂[18F]DCFPyL作为影像学生物标志物
Mohamed Saleh Ismail,Diane E Peters,Steven P Rowe et al.
Mohamed Saleh Ismail et al.
Background: Prostate-specific membrane antigen (PSMA) is highly and specifically upregulated in active-inflamed mucosa of patients with inflammatory bowel disease (IBD). We hypothesized that this upregulation would be det...
Gardenia Iridoid Glucosides Protect Against α-Naphthalene Isothiocya-Nate-Induced Cholestatic Rats Through Activation of the FXR-SHP Signaling Pathway [0.03%]
白花丹参素通过激活FXR-SHP信号通路保护α-萘异硫氰酸盐诱导的胆汁淤积大鼠肝脏损伤
Meng Xu,Ke Che,Cong Wang et al.
Meng Xu et al.
Introduction: Cholestasis is a common liver disorder that currently has limited treatment options. Gardenia Iridoid Glucosides (GIG) have been found to possess various physiological activities, such as cholagogic, hypogly...
Body Mass Index Profile of Adult Patients with Inflammatory Bowel Disease in a Multicenter Study in Northeastern Brazil [0.03%]
巴西东北部多中心炎症性肠病成人患者体质指数分析
Jones Silva Lima,Carlos Alexandre Antunes de Brito,Lívia Medeiros Soares Celani et al.
Jones Silva Lima et al.
Purpose: Inflammatory bowel disease (IBD) is a disease of increasing prevalence in developing countries. Obesity has emerged as a potential risk for IBD; however, the data in the literature are conflicting, and relevant s...
Dumping Syndrome: Pragmatic Treatment Options and Experimental Approaches for Improving Clinical Outcomes [0.03%]
倾倒综合征的实用治疗选择及改善临床疗效的实验方法
Gwen M C Masclee,Ad A M Masclee
Gwen M C Masclee
Dumping syndrome is a common complication after esophageal, gastric and bariatric surgery and has a significant negative impact on the quality of life of patients. This narrative review describes the clinical syndrome, pathophysiology, diag...
Indications and Findings of Upper Gastrointestinal Endoscopy at a Tertiary Hospital in Ethiopia: A Cross-Sectional Study [0.03%]
埃塞俄比亚一家三级医院上消化道内镜的适应证和结果：一项横断面研究
Abel Mureja Argaw,Samrawit Solomon Ethiopia,Geda Lelisa et al.
Abel Mureja Argaw et al.
Background: Gastrointestinal disease is a significant global health problem. Symptoms related to digestive system diseases negatively affect quality of life and impose a significant economic impact. Upper gastrointestinal...
Wandering Spleen and Acute Gastric Volvulus in an Elderly Woman with Acute Abdomen: A Case Report [0.03%]
老年急性腹痛患者游走脾和急性胃扭转1例报告
Somprakas Basu,Arvind Pratap,Satyanam Kumar Bhartiya et al.
Somprakas Basu et al.
Gastric volvulus is an uncommon clinical condition with the potentially life-threatening complication of acute gastric necrosis. A wandering spleen may also be associated with gastric volvulus and can produce a diagnostic dilemma as the cau...