Update on the management of inflammatory bowel disease: specific role of adalimumab [0.03%]
炎症性肠病的治疗进展：阿达利姆单抗的独特作用
Luisa Guidi,Daniela Pugliese,Alessandro Armuzzi
Luisa Guidi
Anti-tumor necrosis factor alpha (TNF-α) medications are a class of biologics employed in the treatment of patients with inflammatory bowel disease (IBD). Adalimumab is the first fully human monoclonal immunoglobulin directed against TNF-...
Similarity of hydrolyzing activity of human and rat small intestinal disaccharidases [0.03%]
人和大鼠小肠双糖酶水解活性的比较
Tsuneyuki Oku,Kenichi Tanabe,Shigeharu Ogawa et al.
Tsuneyuki Oku et al.
Background: The purpose of this study was to clarify whether it is possible to extrapolate results from studies of the hydrolyzing activity of disaccharidases from rats to humans. ...
Clinical, endoscopical and morphological efficacy of mesalazine in patients with irritable bowel syndrome [0.03%]
美沙拉秦治疗肠易激综合征患者的临床、内镜及形态学疗效分析
Andrey E Dorofeyev,Elena A Kiriyan,Inna V Vasilenko et al.
Andrey E Dorofeyev et al.
Objectives: The aim of this study was to analyze the clinical efficacy and cytomorphologic changes of colon mucosa following the treatment of patients suffering from irritable bowel syndrome (IBS) with mesalazine (5-amino...
Current and future role of biomarkers in Crohn's disease risk assessment and treatment [0.03%]
生物标志物在克罗恩病风险评估和治疗中的当前和未来作用
Cyrus P Tamboli,David B Doman,Amar Patel
Cyrus P Tamboli
Background: Crohn's disease (CD), a chronic inflammatory bowel disease (IBD), occurs in genetically susceptible individuals who develop aberrant immune responses to endoluminal bacteria. Recurrent inflammation increases t...
Celiac disease and immigration in Northeastern Italy: the "drawn double nostalgia" of "cozonac" and "panettone" slices [0.03%]
自身免疫性疾病的移民问题以东北意大利为例：“可颂”与“米兰甜酒蛋糕”的“双重思乡之情”
Sergio Parco,Angelo Città,Fulvia Vascotto et al.
Sergio Parco et al.
Many investigators consider children's drawings to be an important test in the evaluation of stress and anxiety, but few studies have examined the reliability and validity of indicators of emotional distress in children's projective drawing...
Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis [0.03%]
染色体1号短臂缺失在结肠癌发生过程中的分子和细胞通路研究
Claire M Payne,Cheray Crowley-Skillicorn,Carol Bernstein et al.
Claire M Payne et al.
Chromosomal instability is a major pathway of sporadic colon carcinogenesis. Chromosome arm 1p appears to be one of the "hot spots" in the non-neoplastic mucosa that, when deleted, is associated with the initiation of carcinogenesis. Chromo...
Enzyme replacement therapy for pancreatic insufficiency: present and future [0.03%]
胰腺外分泌不足的酶替代治疗：现状和未来
Aaron Fieker,Jessica Philpott,Martine Armand
Aaron Fieker
Pancreatic enzyme replacement therapy is currently the mainstay of treatment for nutrient malabsorption secondary to pancreatic insufficiency. This treatment is safe and has few side effects. Data demonstrate efficacy in reducing steatorrhe...
Relationship between hepatic CTGF expression and routine blood tests at the time of liver transplantation for biliary atresia: hope or hype for a biomarker of hepatic fibrosis [0.03%]
胆道闭锁肝移植时肝脏CTGF表达与常规血液检测结果之间的关系：有望成为肝纤维化生物标志物吗？
Allah Haafiz,Christian Farrington,Joel Andres et al.
Allah Haafiz et al.
Background: Progressive hepatic fibrosis (HF) is a prominent feature of biliary atresia (BA), the most common indication for liver transplantation (LT) in children. Despite its importance in BA, HF is not evaluated in rou...
High-dose rifaximin treatment alleviates global symptoms of irritable bowel syndrome [0.03%]
高剂量利福昔明治疗可缓解肠易激综合征的整体症状
John Jolley
John Jolley
Background: To evaluate the efficacy of rifaximin for reduction of gastrointestinal symptoms in patients with irritable bowel syndrome (IBS). Methods: ...
Luca Dughera,Michele Chiaverina,Luca Cacciotella et al.
Luca Dughera et al.
Several theories on the etiology and pathophysiology of achalasia have been reported but, to date, it is widely accepted that loss of peristalsis and absence of swallow-induced relaxation of the lower esophageal sphincter are the main funct...