Nanne Kh de Boer,Mark Löwenberg,Frank Hoentjen
Nanne Kh de Boer
Anti-tumor necrosis factor therapy with adalimumab is an effective therapy for the induction and maintenance of remission in moderate to severe Crohn's disease. Although a large proportion of patients show a favorable clinical response to a...
Long-term efficacy and safety of otilonium bromide in the management of irritable bowel syndrome: a literature review [0.03%]
溴化奥替普拉治疗肠易激综合征的长期疗效和安全性：文献回顾
John K Triantafillidis,George Malgarinos
John K Triantafillidis
Irritable bowel syndrome (IBS) is a very common functional gastrointestinal disorder characterized by abdominal pain or discomfort and altered bowel habits. The disease affects a large part of the world population. The clinical course is mo...
Hideki Kobara,Hirohito Mori,Kazi Rafiq et al.
Hideki Kobara et al.
Advances in endoscopic submucosal dissection include a submucosal tunneling technique, involving the introduction of tunnels into the submucosa. These tunnels permit safer offset entry into the peritoneal cavity for natural orifice translum...
From depolarization-dependent contractions in gastrointestinal smooth muscle to aortic pulse-synchronized contractions [0.03%]
从胃肠平滑肌去极化依赖性收缩到主动脉脉动同步收缩
Sarah B Marion,Allen W Mangel
Sarah B Marion
For decades, it was believed that the diameter of gastrointestinal smooth muscle cells is sufficiently narrow, and that the diffusion of calcium across the plasma membrane is sufficient, to support contractile activity. Thus, depolarization...
Mark Löwenberg,Nanne Kh de Boer,Frank Hoentjen
Mark Löwenberg
The introduction of therapeutic antibodies against tumor necrosis factor (TNF) had a major impact on the treatment of ulcerative colitis (UC). Infliximab and adalimumab are powerful agents that are used for remission induction and maintenan...
Serotonin (5-HT3) receptor antagonists for the reduction of symptoms of low anterior resection syndrome [0.03%]
五羟色胺(5-HT3)受体拮抗剂可减轻低位前切症候群的症状
Ryohei Itagaki,Keiji Koda,Masato Yamazaki et al.
Ryohei Itagaki et al.
Purpose: Serotonin (5-hydroxytryptamine [5-HT])3 receptor antagonists are effective for the treatment of diarrhea-predominant irritable bowel syndrome (IBS-D), in which exaggerated intestinal/colonic hypermotility is ofte...
Long-term safety and efficacy of budesonide in the treatment of ulcerative colitis [0.03%]
布地奈德治疗溃疡性结肠炎长期安全性和有效性的研究
Marisa Iborra,Diego Alvarez-Sotomayor,Pilar Nos
Marisa Iborra
Ulcerative colitis (UC) is a chronic, relapsing, and remitting inflammatory disease involving the large intestine (colon). Treatment seeks to break recurrent inflammation episodes by inducing and maintaining remission. Historically, oral sy...
Maureen M Leonard,Brintha Vasagar
Maureen M Leonard
The incidence of allergy and autoimmune disease in the US and other industrialized nations is increasing, and gluten-related disorders are no exception. The US has documented a profound rise in celiac disease that cannot be fully explained ...
Therapeutic treatment with a novel hypoxia-inducible factor hydroxylase inhibitor (TRC160334) ameliorates murine colitis [0.03%]
一种新型低氧诱导因子羟化酶抑制剂(TRC160334)的治疗作用可改善小鼠结肠炎
Ram Gupta,Anita R Chaudhary,Binita N Shah et al.
Ram Gupta et al.
Background and aim: Mucosal healing in inflammatory bowel disease (IBD) can be achieved by improvement of intestinal barrier protection. Activation of hypoxia-inducible factor (HIF) has been identified as a critical facto...
Treatment of relapsing Clostridium difficile infection using fecal microbiota transplantation [0.03%]
用粪菌移植治疗复发性难辨梭菌感染
Rahul Pathak,Hill Ambrose Enuh,Anish Patel et al.
Rahul Pathak et al.
Background: Clostridium difficile infection (CDI) has become a global concern over the last decade. In the United States, CDI escalated in incidence from 1996 to 2005 from 31 to 64/100,000. In 2010, there were 500,000 cas...