Optimising Monoclonal Antibody Drug Development for Inflammatory Bowel Disease [0.03%]
优化单克隆抗体药物开发以治疗炎症性肠病
Michael Colwill,Sailish Honap,Silvio Danese et al.
Michael Colwill et al.
Despite the success of monoclonal antibody (mAb) therapies in treating inflammatory bowel disease (IBD), a persistent therapeutic ceiling remains. This comprehensive review explores emerging strategies to enhance the efficacy of mAb-based t...
Colonic Mucosal Gene Expression Profile in Patients with Neoplastic Progression in Longstanding Ulcerative Colitis [0.03%]
长期溃疡性结肠炎患者肿瘤进展的结肠黏膜基因表达谱特征分析
Lene Alsøe,Stephan Andreas Brackmann,Yohan Lefol et al.
Lene Alsøe et al.
Purpose: Long-standing mucosal inflammation is suspected to be one of the main drivers of colitis-associated colorectal cancer (CA-CRC), but far from all colitis patients develop cancer. Non-neoplastic mucosa located dist...
Panenteric Capsule Endoscopy in Young Patients with Suspected Irritable Bowel Syndrome: A Self-Controlled Feasibility Study [0.03%]
怀疑患肠易激综合征的年轻患者全小肠胶囊内镜检查自我对照可行性研究
Robert Benamouzig,Walaa El Arja,Bakthiar Bejou et al.
Robert Benamouzig et al.
Objective: Although the diagnosis of irritable bowel syndrome (IBS) is based on clinical criteria, a colonoscopy is often performed to rule out alternative digestive disorders. The panenteric PillCam™ Crohn's capsule, wh...
Patatin-Like Phospholipase Domain-Containing Protein 3 (PNPLA3) rs738409 Variant and Non-Alcoholic Fatty Liver Disease Risk in Vietnamese Working-Age Adults: A Case-Control Study with Metabolic Insights [0.03%]
Patatin样磷脂酶结构域含3蛋白多态型与越南劳动年龄成人非酒精性脂肪肝病风险：一项代谢机制病例对照研究
Ha Minh Nguyen,Duong Hoang Huy Le,Thinh Hung Nguyen et al.
Ha Minh Nguyen et al.
Background: Non-alcoholic fatty liver disease (NAFLD) is an increasing public health concern in Vietnam, particularly among working-age adults (18-60 years). The PNPLA3 rs738409 variant (C>G) is a well-established risk fa...
Characterization of Bacterial Biofilm Composition in Occluded Plastic Biliary Stents [0.03%]
塑料胆道支架堵塞的细菌生物被膜组成特征分析
Victor Kalil Flumignan,Marcelo Palma Sircili,Lígia Garcia Germano et al.
Victor Kalil Flumignan et al.
Purpose: Plastic biliary stents are an effective treatment for biliary obstruction. Despite being resolutive and accessible, they are known to have a low patency rate, estimated at 3 to 6 months. This can be attributed to...
Serological Markers of Intestinal Barrier Function and Inflammation as Potential Predictors of Recurrent Primary Sclerosing Cholangitis [0.03%]
肠屏障功能和炎症的血清学标志物可能预测原发性硬化性胆管炎复发的风险
Mojmir Hlavaty,Jan Brezina,Tetiana Osadcha et al.
Mojmir Hlavaty et al.
The impairment of intestinal barrier function is implicated in primary sclerosing cholangitis, but the clinical evidence is scarce. Therefore, we performed a cross-sectional study to evaluate serological markers of inflammation and intestin...
Clinically Adult-Onset Nesidioblastosis with Repeated Severe Hypoglycemia, Successfully Treated by Two Times Pancreatectomies. A Rare Case Report [0.03%]
临床迟发性Nesidioblastosis反复严重低血糖经两次手术成功治疗的罕见病例报告
Wataru Izumo,Ryota Higuchi,Masahiro Shiihara et al.
Wataru Izumo et al.
Although nesidioblastosis is the most common cause of hyperinsulinemic hypoglycemia in infants, it is rare in adults. Nesidioblastosis is pathologically characterized by diffuse neoformation of the islets of Langerhans islets from the pancr...
Diagnosis and Management of Gastroesophageal Reflux Disease: Current Insights [0.03%]
胃食管反流病的诊断和管理：当前见解
Abhinav Vayal-Veettil,C Prakash Gyawali
Abhinav Vayal-Veettil
Gastroesophageal reflux disease (GERD) results from retrograde movement of gastric content into the esophagus and beyond, resulting in symptoms, mucosal injury and long-term complications. Typical symptoms of heartburn and regurgitation are...
Primary Biliary Cholangitis and Seropositive Rheumatoid Arthritis: A Two-Sample Mendelian Randomization Study [0.03%]
原发性胆汁性胆管炎与类风湿关节炎的遗传关联：两样本孟德尔随机化研究
Zongqi Deng,Wanyang Lei,Xiao Kuang et al.
Zongqi Deng et al.
Background: Observational studies indicated potential associations between primary biliary cholangitis (PBC) and rheumatoid arthritis (RA). However, the causal relationship between RA and PBC remains unclear and controver...
Microbial Patterns in Newly Diagnosed Inflammatory Bowel Disease Revealed by Presence and Transcriptional Activity - Relationship to Diagnosis and Outcome [0.03%]
肠道新诊断的炎症性肠病中的微生物模式及其与诊断和预后的关联
Simen Svendsen Vatn,Simen Hyll Hansen,Tone Møller Tannæs et al.
Simen Svendsen Vatn et al.
Background: As part of the IBD Character initiative, we examined an inception cohort and investigated mucosal microbiota composition and transcriptional activity in relation to clinical outcomes. ...