Emma Westermann-Clark,Amber N Pepper,Richard F Lockey
Emma Westermann-Clark
Epinephrine is a life-saving medication used to treat systemic allergic reactions including anaphylaxis. Epinephrine autoinjectors (EAIs) are expensive and worldwide availability is limited. Epinephrine prefilled syringes and epinephrine ki...
Underuse of epinephrine for the treatment of anaphylaxis: missed opportunities [0.03%]
肾上腺素治疗过敏反应应用不足：机会丧失
Benjamin T Prince,Irene Mikhail,David R Stukus
Benjamin T Prince
Epinephrine is the only effective treatment for anaphylaxis but studies routinely show underutilization. This is especially troubling given the fact that fatal anaphylaxis has been associated with delayed administration of epinephrine. Many...
Anaphylaxis in the 21st century: phenotypes, endotypes, and biomarkers [0.03%]
二十一世纪的过敏性休克：表型、内型和生物标志物
Teodorikez Wilfox Jimenez-Rodriguez,Marlene Garcia-Neuer,Leila A Alenazy et al.
Teodorikez Wilfox Jimenez-Rodriguez et al.
Anaphylaxis is the most serious of all allergic reactions and can be fatal. The diagnosis is frequently delayed, and misdiagnosis often occurs with asthma or urticaria. Biomarkers such as tryptase are not routinely checked, and appropriate ...
David Yue,Amanda Ciccolini,Ernie Avilla et al.
David Yue et al.
Anaphylaxis is a severe and potentially life-threatening allergic reaction. There are numerous potential causes, with food allergy being the leading cause in children and the focus of this review. Most reactions involve an IgE-mediated mech...
Anaphylaxis: getting to the point (and price) of diagnosis and treatment [0.03%]
急性过敏反应：明确诊断和治疗的关键(及费用)
Ronald B Moss
Ronald B Moss
Omalizumab in allergic bronchopulmonary aspergillosis in patients with cystic fibrosis [0.03%]
过敏性支气管肺曲霉病患者的奥马珠单抗治疗
Moshe Ashkenazi,Saray Sity,Ifat Sarouk et al.
Moshe Ashkenazi et al.
Background: Allergic bronchopulmonary aspergillosis (ABPA) is a condition characterized by a Th2 response, serum eosinophilia, and increased total serum IgE to Aspergillus fumigatus. ABPA occurs in cystic fibrosis (CF) an...
Beth E Davis,Christianne M Blais,Donald W Cockcroft
Beth E Davis
Standardization of the methacholine inhalation challenge, the most common direct bronchoprovocation test, is important. One aspect of standardization is the appropriate washout period for pharmacologic agents which affect the response. This...
Acute effects of smoke exposure on airway and systemic inflammation in forest firefighters [0.03%]
森林消防员烟雾暴露对气道和全身炎症的急性影响
Niki Gianniou,Charilena Giannakopoulou,Efrossini Dima et al.
Niki Gianniou et al.
Introduction: The aim of this study was to assess respiratory health and airway and systemic inflammation in professional forest firefighters post firefighting. ...
Both fractional exhaled nitric oxide and sputum eosinophil were associated with uncontrolled asthma [0.03%]
呼出气一氧化氮和痰液嗜酸性粒细胞与支气管哮喘相关性研究
Jie Gao,Zhaocheng Chen,Xiang Jie et al.
Jie Gao et al.
Background: Sputum eosinophil and fractional exhaled nitric oxide (FeNO), noninvasive biomarkers of local eosinophilic airway inflammation, can be used to assess asthma outcome. Nevertheless, the clinical application of t...
Assessment of an accessorized pre-filled syringe for home-administered benralizumab in severe asthma [0.03%]
评估辅有助手的预装注射器在家用重症哮喘本拉利珠单抗治疗中的应用效果
Gary T Ferguson,Adel H Mansur,Joshua S Jacobs et al.
Gary T Ferguson et al.
Background: Patients prefer at-home subcutaneous administration of biologics across different diseases, yet no biologic is approved for at-home use for severe, uncontrolled asthma. ...