Polysensitization Patterns and Age-Dependent Allergen Profiles in Children from Suzhou, China: A Component-Resolved Cross-Sectional Study [0.03%]
中国苏州儿童多敏化模式及年龄依赖性过敏原谱特征：基于组分解析的横断面研究
Qiuyan Xu,Haowei Zhao,Yongchao Dong et al.
Qiuyan Xu et al.
Purpose: Allergic diseases are a major global public health issue with a rising pediatric prevalence. This study explored the allergen sensitization profiles, cross-reactivity, and polysensitization patterns among pediatr...
Serum Midkine as a Potential Biomarker Associated with Disease Severity and Remodeling-Related Mediators in Children with Asthma [0.03%]
哮喘儿童血清midkine与疾病严重程度及重塑相关介质的关联研究
Yongtian Xu,Lixia Zhao,Yingying Mi et al.
Yongtian Xu et al.
Introduction: Asthma is a heterogeneous inflammatory airway disease in children, for which reliable circulating biomarkers reflecting disease severity and remodeling-associated inflammation remain limited. Midkine, a hepa...
Impact of Dupilumab on the Skin Microbiome in Children Aged 6-12 years with Moderate-to-Severe Atopic Dermatitis [0.03%]
Dupixent对6至12岁中重度特应性皮炎儿童皮肤微生物群的影响
Yan Liu,Shan Wang,Ying Liu et al.
Yan Liu et al.
Purpose: We aimed to investigate alterations in the skin microbiome following treatment and discontinuation of dupilumab in children with atopic dermatitis (AD). ...
Designing an Incremental Egg Oral Immunotherapy Protocol: A Strategic Approach with Safety as a Priority [0.03%]
一种以安全为优先的 incremental 进食鸡蛋口服免疫疗法方案的设计及战略思考
Darin Munyuen,Araya Yuenyongviwat,Pasuree Sangsupawanich et al.
Darin Munyuen et al.
Purpose: Egg oral immunotherapy (OIT) has demonstrated clinical efficacy; however, 10-35% of patients discontinue treatment due to severe adverse reactions, particularly during the build-up phase. To improve safety, we de...
Systemic Immune Dysregulation in Allergic Rhinitis: Mechanisms, Comorbidities, and Implications for Targeted Therapy [0.03%]
过敏性鼻炎的全身免疫失调：机制、共病和靶向治疗的意义
Danni Hui,Caizhen Shi,Yanpeng Fan et al.
Danni Hui et al.
Allergic rhinitis (AR) has traditionally been regarded as a localized inflammatory disorder of the nasal mucosa. However, accumulating evidence indicates that AR is associated with systemic immune dysregulation characterized by peripheral e...
Comparative Evaluation of Four Multiple Allergen Simultaneous Test (MAST) Systems in Clinical Practice [0.03%]
四种联合过敏原检测试验在临床应用中的比较评价研究
Sojin Lee,Junhyup Song,Kyung-A Lee et al.
Sojin Lee et al.
Purpose: Multiple allergen simultaneous tests (MASTs) are widely used for screening allergen-specific immunoglobulin E owing to their convenience and cost-effectiveness. Recently, several automated MAST analyzers with exp...
The Effect of Vitamin D Levels on Asthma Exacerbation in Asthmatic Patients in a Tertiary Hospital: Retrospective Study [0.03%]
维生素D水平对三级医院哮喘患者急性加重的影响：回顾性研究
Alaa A Alhubaishi,Nora K Almutairi,Reem A Alghamdi et al.
Alaa A Alhubaishi et al.
Background: Asthma is a major global health issue, affecting over 260 million individuals and causing more than 450,000 deaths annually. A growing body of international and local research has investigated the link between...
Clinical Efficacy of Acupuncture as Adjunctive Therapy for Cough Variant Asthma: Study Protocol for a Pilot Randomized Controlled Trial [0.03%]
用于治疗咳嗽变异性哮喘的补肾化痰针刺辅助疗法临床疗效可行性研究方案
Xi Chen,Yilin Liu,Hangyu Li et al.
Xi Chen et al.
Background: Cough variant asthma (CVA) is a clinically significant asthma phenotype and a major cause of chronic cough, with a substantial risk of progressing to classic asthma. Acupuncture has shown potential in alleviat...
A Case of Eosinophilic Granulomatosis with Polyangiitis Emerging During Benralizumab Therapy: Successful Management Through a Switch to Mepolizumab Therapy [0.03%]
一例英夫利西单抗治疗期间出现嗜酸性肉芽肿伴聚血管炎：换用美泊利单抗治疗后成功管理病例报告
Yuki Saito,Jun Ito,Takayasu Watanabe et al.
Yuki Saito et al.
Background: Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitis characterized by eosinophilic inflammation and involvement of small- to medium-sized vessels. Given its heterogeneous clinical...
Significant Production of Serum and Mucosal Anti-Spike-IgA Antibodies After Vaccine-Encoded or SARS-CoV-2-Infection-Induced Spike-Exposures in Patients with Asthma Treated with Monoclonal Antibodies Compared to Conventional Therapy [0.03%]
与传统治疗相比，接受单克隆抗体治疗的哮喘患者在接种疫苗或感染诱导后产生血清和粘膜抗刺突-IgA抗体的能力较强
Giovanni Almanzar,Anna Broderdörp,Juliane Mees et al.
Giovanni Almanzar et al.
Introduction: It has been proposed that patients with asthma on monoclonal antibodies (mAb) targeting Interleukin-5 (IL-5), IL-4/IL-13 pathways or IgE may demonstrate insufficient defense against viral infections requirin...