Cardiorespiratory and Glycaemic Changes Following Prehospital Nebulised Salbutamol in Acute Asthma: A Mixed Retrospective and Prospective Observational Study [0.03%]
急性哮喘院前雾化沙丁胺醇的糖代谢和心肺变化：一项混合性回顾性和前瞻性观察研究
Craig Mortimer,Dimitra Nikoletou,Ann Ooms et al.
Craig Mortimer et al.
Purpose: In 2010, the Global Strategy for Asthma Management and Prevention recommended reducing the reliance on treating acute asthma exacerbations with short-acting β2 agonists (SABAs) given potential adverse effects. H...
Appropriate Use of Single Inhaled Triple Therapy in Uncontrolled Asthma: A Multinational Modified Delphi Consensus [0.03%]
单用吸入三联疗法治疗控制不佳的哮喘的适宜应用：多国改良德尔菲共识
Dilsad Mungan,Arturo Cortes-Telles,Mahmoud Mokhtar et al.
Dilsad Mungan et al.
Introduction: Uncontrolled asthma is associated with impaired lung function, higher frequency of severe exacerbations, reduced quality of life, and increased healthcare costs. Although inhaled corticosteroids with long-ac...
A Multi-Compartment Cytological Approach to Severe Asthma Phenotyping: The BRISA Study (Biomedical Research in Severe Asthma) [0.03%]
基于细胞学的多隔室亚型化重度哮喘研究（BRISA 研究，即重度哮喘的生物医学研究）
Javier Domínguez-Ortega,Gabriela Leon-Zambrana,José Antonio Cañas et al.
Javier Domínguez-Ortega et al.
Background: Accurate inflammatory phenotyping in asthma remains challenging. Nasal cytology has emerged as a potential non-invasive tool to assess airway inflammation in asthma. However, its relationship with lower airway...
A Comparative Study of Type 2 Inflammatory Biomarkers Combined with Small Airway Parameters for Diagnosing Cough-Variant Asthma [0.03%]
联合运用第2型炎症生物标志物和小气道参数诊断咳嗽变异性哮喘的比较研究
Eloina Margarita Mokuy Ondo Osie,Haodong Bai,Jianjun Liu et al.
Eloina Margarita Mokuy Ondo Osie et al.
Background: The diagnosis of cough-variant asthma (CVA) traditionally relies on clinical manifestations and bronchial provocation test (BPT). However, the BPT can be costly and complex, and poses risks of severe bronchosp...
Multidisciplinary Recommendations for the Use of Chest CT and Bronchial Biopsy in Severe Asthma: An Expert Consensus Based on Real-World Experience [0.03%]
基于真实世界经验的重度哮喘患者胸部CT和支气管活检多学科应用专家共识推荐
Juan Luis Garcia-Rivero,Elena Peña,Ana González-Piñeiro et al.
Juan Luis Garcia-Rivero et al.
Background: Chest computed tomography (CT) and bronchial biopsy can refine severe asthma phenotyping beyond systemic biomarkers, yet real-world implementation re mains heterogeneous and reporting is often non-standardized...
Precision Prediction of Pediatric Subcutaneous Immunotherapy Outcomes Using a Clinical Nomogram for House Dust Mite Allergy [0.03%]
基于临床预测模型的尘螨皮下免疫治疗疗效精准预测研究
Shi-Jie Zhuang,Ting-Ting Fan,Rong-Li Lai et al.
Shi-Jie Zhuang et al.
Background: The identification of predictive biomarkers for subcutaneous immunotherapy (SCIT) is of great importance for improving its clinical efficacy. This study aims to construct a nomogram predicting the efficacy of ...
Eosinophilic Depletion with Benralizumab, Mepolizumab, and Depemokimab: A Modeling Study [0.03%]
贝那利珠单抗、美泊利单抗和德佩莫基姆单抗下嗜酸性粒细胞的耗竭：一项建模研究
Pradeep B Lukka,Robert C Penland,Ari Brekkan et al.
Pradeep B Lukka et al.
Purpose: Anti-interleukin (IL)-5/IL-5 receptor therapies are an integral part of the management of patients with severe eosinophilic asthma. We modeled and compared the blood eosinophil (bEOS) depletion response following...
Severity-Dependent Association Between Allergic Rhinitis and Adenoid Hypertrophy in Dust Mite-Sensitized Children from Northern China: A Cross-Sectional Analysis of 170 Cases [0.03%]
中国北方尘螨过敏儿童过敏性鼻炎和腺样体肥厚严重程度相关性的横断面分析（170例报告）
Bo Zhao,Yang Wang,Hongyang Zhang et al.
Bo Zhao et al.
Background: Allergic rhinitis (AR) and adenoid hypertrophy (AH) frequently coexist in children, yet the relationship between allergic disease severity and the extent of adenoid enlargement remains incompletely defined. Th...
Biomarker-Defined Endotypes and Clinical Phenotypes of Asthma: A Cluster-Based Analysis of Type-2 Inflammatory Patterns and Their Clinical Correlates [0.03%]
基于聚类的哮喘生物标志物定义亚型和临床表型分析：2 型炎症模式及其临床关联
Ibrahim Hamdy Elsayed Feteih,Asmaa Ali
Ibrahim Hamdy Elsayed Feteih
Background: Asthma is a biologically heterogeneous disease characterized by diverse inflammatory mechanisms, yet the clinical translation of this heterogeneity into clearly defined, biomarker-driven endotypes remains limi...
Impact of Fluticasone Furoate/Vilanterol on Small Airway Function in Asthma: A Real- World Study Using Impulse Oscillometry Stratified by Eosinophilic Inflammation [0.03%]
布地奈德福莫特罗对哮喘小气道功能影响的现实世界研究：基于嗜酸性炎症分层分析的阻抗振荡评估
Wei-Chun Huang,Chia-Hung Chen,Chih-Yen Tu et al.
Wei-Chun Huang et al.
Background: Small airway dysfunction (SAD) is a key component of asthma pathophysiology that may persist despite adequate treatment. Impulse oscillometry (IOS) provides sensitive detection of peripheral airway abnormaliti...