A rapid method for combined analysis of common and rare variants at the level of a region, gene, or pathway [0.03%]
一种在区域、基因或通路水平上综合分析常见变异和稀有变异的快速方法
David Curtis
David Curtis
Previously described methods for the combined analysis of common and rare variants have disadvantages such as requiring an arbitrary classification of variants or permutation testing to assess statistical significance. Here we propose a nov...
Role of Shwachman-Bodian-Diamond syndrome protein in translation machinery and cell chemotaxis: a comparative genomics approach [0.03%]
比较基因组学方法研究DWTS蛋白在细胞翻译和趋化中的作用
Olga Vasieva
Olga Vasieva
Shwachman-Bodian-Diamond syndrome (SBDS) is linked to a mutation in a single gene. The SBDS proinvolved in RNA metabolism and ribosome-associated functions, but SBDS mutation is primarily linked to a defect in polymorphonuclear leukocytes u...
Rui-Ru Ji,Karl-Heinz Ott,Roumyana Yordanova et al.
Rui-Ru Ji et al.
Gene set enrichment analysis for analyzing large profiling and screening experiments can reveal unifying biological schemes based on previously accumulated knowledge represented as "gene sets". Most of the existing implementations use a fix...
Affinity of estrogens for human progesterone receptor A and B monomers and risk of breast cancer: a comparative molecular modeling study [0.03%]
雌激素与人孕激素受体A和B单体的亲和力及乳腺癌风险：比较分子建模研究
Tarique N Hasan,Leena Grace B,Tariq A Masoodi et al.
Tarique N Hasan et al.
Background: The human progesterone receptor (hPR) belongs to the steroid receptor family. It may be found as monomers (A and B) and or as a dimer (AB). hPR is regarded as the prognostic biomarker for breast cancer. In a c...
LifePrint: a novel k-tuple distance method for construction of phylogenetic trees [0.03%]
生命印迹：一种新颖的k-元组距离法用于生成系谱树
Fabián Reyes-Prieto,Adda J García-Chéquer,Hueman Jaimes-Díaz et al.
Fabián Reyes-Prieto et al.
Purpose: Here we describe LifePrint, a sequence alignment-independent k-tuple distance method to estimate relatedness between complete genomes. Methods: ...
Akito Taneda
Akito Taneda
Artificially synthesized RNA molecules have recently come under study since such molecules have a potential for creating a variety of novel functional molecules. When designing artificial RNA sequences, secondary structure should be taken i...
SNP analysis of follistatin gene associated with polycystic ovarian syndrome [0.03%]
与多囊卵巢综合症相关的抗苗勒管激素基因SNP分析
Palanisamy Panneerselvam,Kanakarajan Sivakumari,Ponmani Jayaprakash et al.
Palanisamy Panneerselvam et al.
Follistatin has been reported as a candidate gene for polycystic ovarian syndrome (PCOS) based on linkage and association studies. In this study, investigation of polymorphisms in the FST gene was done to determine if genetic variation is a...
A kinetic platform for in silico modeling of the metabolic dynamics in Escherichia coli [0.03%]
大肠杆菌代谢动力学的计算机模拟平台
Aditya Barve,Anvita Gupta,Suresh M Solapure et al.
Aditya Barve et al.
Background: A prerequisite for a successful design and discovery of an antibacterial drug is the identification of essential targets as well as potent inhibitors that adversely affect the survival of bacteria. In order to...
Mehdi Sadeghi,Hamid Pezeshk,Changiz Eslahchi et al.
Mehdi Sadeghi et al.
Purpose: Interest in developing methods appropriate for mapping increasing amounts of genome-wide molecular data are increasing rapidly. There is also an increasing need for methods that are able to efficiently simulate s...
Efficient algorithms for multidimensional global optimization in genetic mapping of complex traits [0.03%]
复杂性状遗传图谱多维全局优化的高效算法
Kajsa Ljungberg,Kateryna Mishchenko,Sverker Holmgren
Kajsa Ljungberg
We present a two-phase strategy for optimizing a multidimensional, nonconvex function arising during genetic mapping of quantitative traits. Such traits are believed to be affected by multiple so called quantitative trait loci (QTL), and se...