In silico structure-based screening of versatile P-glycoprotein inhibitors using polynomial empirical scoring functions [0.03%]
基于多项式经验打分函数的泛P-糖蛋白抑制剂的从头设计与筛选
Sergey Shityakov,Carola Förster
Sergey Shityakov
P-glycoprotein (P-gp) is an ATP (adenosine triphosphate)-binding cassette transporter that causes multidrug resistance of various chemotherapeutic substances by active efflux from mammalian cells. P-gp plays a pivotal role in limiting drug ...
Hypergeometric analysis of tiling-array and sequence data: detection and interpretation of peaks [0.03%]
平面数组和序列数据的超几何分析及峰特征的检测与解读
Erdogan Taskesen,Remco Hoogeboezem,Ruud Delwel et al.
Erdogan Taskesen et al.
Probing protein-deoxyribonucleic acid (DNA) is gaining popularity as it sheds light on molecular mechanisms that regulate the expression of genes. Currently, tiling-arrays and next-generation sequencing technology can be used to measure the...
Design of multiligand inhibitors for the swine flu H1N1 neuraminidase binding site [0.03%]
猪流感H1N1神经氨酸酶结合位点多配体抑制剂的设计
Manoj M Narayanan,Chandrasekhar B Nair,Shilpa K Sanjeeva et al.
Manoj M Narayanan et al.
Viral neuraminidase inhibitors such as oseltamivir and zanamivir prevent early virus multiplication by blocking sialic acid cleavage on host cells. These drugs are effective for the treatment of a variety of influenza subtypes, including sw...
Antigenic heterogeneity of capsid protein VP1 in foot-and-mouth disease virus (FMDV) serotype Asia 1 [0.03%]
口蹄疫病毒A型衣壳蛋白VP1的抗原异质性研究
S M Sabbir Alam,Ruhul Amin,Mohammed Ziaur Rahman et al.
S M Sabbir Alam et al.
Foot and mouth disease virus (FMDV), with its seven serotypes, is a highly contagious virus infecting mainly cloven-hoofed animals. The serotype Asia1 occurs mainly in Asian regions. An in-silico approach was taken to reveal the antigenic h...
Approaches to the detection of recessive effects using next generation sequencing data from outbred populations [0.03%]
利用杂交群体的下一代测序数据检测隐性效应的方法
David Curtis
David Curtis
Conventional methods to analyze genome-wide association studies and whole exome or whole genome sequencing studies would be prone to overlook variants which might exert a recessive effect on risk of disease, either as homozygotes or compoun...
Inferences on the biochemical and environmental regulation of universal stress proteins from Schistosomiasis parasites [0.03%]
血吸虫病寄生虫泛应激蛋白的生物化学及环境调控的推理研究
Andreas N Mbah,Ousman Mahmud,Omotayo R Awofolu et al.
Andreas N Mbah et al.
Background: Human schistosomiasis is a freshwater snail-transmitted disease caused by parasitic flatworms of the Schistosoma genus. Schistosoma haematobium, Schistosoma mansoni, and Schistosoma japonicum are the three maj...
Genetic and chemical knockdown: a complementary strategy for evaluating an anti-infective target [0.03%]
基因和化学敲低：评估抗菌靶点的互补策略
Vasanthi Ramachandran,Ragini Singh,Xiaoyu Yang et al.
Vasanthi Ramachandran et al.
The equity of a drug target is principally evaluated by its genetic vulnerability with tools ranging from antisense- and microRNA-driven knockdowns to induced expression of the target protein. In order to upgrade the process of antibacteria...
Contact-based ligand-clustering approach for the identification of active compounds in virtual screening [0.03%]
基于接触的配体聚类方法在虚拟筛选中识别活性化合物
Alexey B Mantsyzov,Guillaume Bouvier,Nathalie Evrard-Todeschi et al.
Alexey B Mantsyzov et al.
Evaluation of docking results is one of the most important problems for virtual screening and in silico drug design. Modern approaches for the identification of active compounds in a large data set of docked molecules use energy scoring fun...
A novel biclustering approach with iterative optimization to analyze gene expression data [0.03%]
一种分析基因表达数据的迭代优化双聚类新方法
Sawannee Sutheeworapong,Motonori Ota,Hiroyuki Ohta et al.
Sawannee Sutheeworapong et al.
Objective: With the dramatic increase in microarray data, biclustering has become a promising tool for gene expression analysis. Biclustering has been proven to be superior over clustering in identifying multifunctional g...
Luciano Giacò,Massimo Amicosante,Maurizio Fraziano et al.
Luciano Giacò et al.
The ability to predict immunogenic regions in selected proteins by in-silico methods has broad implications, such as allowing a quick selection of potential reagents to be used as diagnostics, vaccines, immunotherapeutics, or research tools...