A network biology approach evaluating the anticancer effects of bortezomib identifies SPARC as a therapeutic target in adult T-cell leukemia cells [0.03%]
网络生物学方法评估硼替佐米的抗癌作用并鉴定SPARC蛋白是成人T细胞白血病治疗靶点
Junko H Ohyashiki,Ryoko Hamamura,Chiaki Kobayashi et al.
Junko H Ohyashiki et al.
There is a need to identify the regulatory gene interaction of anticancer drugs on target cancer cells. Whole genome expression profiling offers promise in this regard, but can be complicated by the challenge of identifying the genes affect...
Is gene activity in plant cells affected by UMTS-irradiation? A whole genome approach [0.03%]
UMTS辐射照射影响植物细胞基因表达吗？整体基因组方法研究
Julia C Engelmann,Rosalia Deeken,Tobias Müller et al.
Julia C Engelmann et al.
Mobile phone technology makes use of radio frequency (RF) electromagnetic fields transmitted through a dense network of base stations in Europe. Possible harmful effects of RF fields on humans and animals are discussed, but their effect on ...
Evolution of a domain conserved in microtubule-associated proteins of eukaryotes [0.03%]
真核生物微管相关蛋白中保守结构域的演化
Alex S Rajangam,Hongqian Yang,Tuula T Teeri et al.
Alex S Rajangam et al.
The microtubule network, the major organelle of the eukaryotic cytoskeleton, is involved in cell division and differentiation but also with many other cellular functions. In plants, microtubules seem to be involved in the ordered deposition...
Prion disease induced alterations in gene expression in spleen and brain prior to clinical symptoms [0.03%]
临床前症状出现之前克雅氏病诱导基因表达在脾和脑中的变化
Hyeon O Kim,Greg P Snyder,Tyler M Blazey et al.
Hyeon O Kim et al.
Prion diseases are fatal neurodegenerative disorders that affect animals and humans. There is a need to gain understanding of prion disease pathogenesis and to develop diagnostic assays to detect prion diseases prior to the onset of clinica...
A method to enhance the hit ratio by a combination of structure-based drug screening and ligand-based screening [0.03%]
一种结合基于结构的药物筛选和基于配体的筛选提高命中率的方法
Katsumi Omagari,Daisuke Mitomo,Satoru Kubota et al.
Katsumi Omagari et al.
We examined the procedures to combine two different in silico drug-screening results to achieve a high hit ratio. When the 3D structure of the target protein and some active compounds are known, both structure-based and ligand-based in sili...
Identification of significant genes in genomics using Bayesian variable selection methods [0.03%]
基于Bayesian变量选择方法的基因组学中显著基因识别
Eugene Lin,Lung-Cheng Huang
Eugene Lin
In the studies of genomics, it is essential to select a small number of genes that are more significant than the others for research ranging from candidate gene studies to genome-wide association studies. In this study, we proposed a Bayesi...
Binarization of medical images based on the recursive application of mean shift filtering : Another algorithm [0.03%]
基于均值漂移滤波器递归应用的医学图像二值化算法研究另一算法
Roberto Rodríguez
Roberto Rodríguez
Binarization is often recognized to be one of the most important steps in most high-level image analysis systems, particularly for object recognition. Its precise functioning highly determines the performance of the entire system. According...