David B Ramsden,Rosemary H Waring,Richard B Parsons et al.
David B Ramsden et al.
Single-nucleotide polymorphisms (SNPs) in and around the nicotinamide N-methyltransferase (NNMT) gene are associated with a range of cancers and other diseases and conditions. The data on these associations have been assembled, and their st...
Monica Borghi,Matteo Puccetti,Marilena Pariano et al.
Monica Borghi et al.
Amino acid catabolism occurs during inflammation and regulates innate and adaptive immunity. The role of commensal bacteria in amino acid catabolism and the production of metabolites able to regulate the development and function of the inna...
Adrian C Williams,Lisa J Hill
Adrian C Williams
Nicotinamide homeostasis is a candidate common denominator to explain smooth transitions, whether demographic, epidemiological or economic. This 'NAD world', dependent on hydrogen-based energy, is not widely recognised as it is neither meas...
Induction of tryptophan 2,3-dioxygenase expression in human monocytic leukemia/lymphoma cell lines THP-1 and U937 [0.03%]
诱导人单核细胞白血病/淋巴瘤细胞系THP-1和U937中色氨酸2，3-双氧酶的表达
Delia Hoffmann,Luc Pilotte,Vincent Stroobant et al.
Delia Hoffmann et al.
Tumor-associated macrophages are immune cells with diverse functions in tumor development. Among other functions, they downregulate immune-mediated tumor rejection by depriving lymphocytes of nutrients. The essential amino acid tryptophan i...
Lipopolysaccharide Increases Cortical Kynurenic Acid and Deficits in Reference Memory in Mice [0.03%]
脂多糖增加小鼠皮质犬尿酸和参照记忆缺陷
Lee Peyton,Alfredo Oliveros,Maximilian Tufvesson-Alm et al.
Lee Peyton et al.
Kynurenic acid (KYNA), a glial-derived metabolite of tryptophan metabolism, is an antagonist of the alpha 7 nicotinic acetylcholine receptor and the glycine-binding site of N-methyl-d-aspartate (NMDA) receptors. Kynurenic acid levels are in...
Tryptophan Metabolism as Source of New Prognostic Biomarkers for FAP Patients [0.03%]
色氨酸代谢作为FAP患者新的预后生物标志物来源
Sara Crotti,Chiara Bedin,Antonella Bertazzo et al.
Sara Crotti et al.
Familial adenomatous polyposis (FAP), a common inherited form of colorectal cancer (CRC), causes the development of hundreds to thousands of colonic adenomas in the colorectum beginning in early adolescence. In absence of a prophylactic sur...
The Associations Between Cognitive Prognosis and Kynurenines Are Modified by the Apolipoprotein ε4 Allele Variant in Patients With Dementia [0.03%]
载脂蛋白ε4等位基因变异修饰痴呆患者认知预后与犬尿氨酸代谢物之间的关系
Arne Olav Ervik,Stein-Erik Hafstad Solvang,Jan Erik Nordrehaug et al.
Arne Olav Ervik et al.
Background: The apolipoprotein E ε4 gene variant (APOEε4) confers considerable risk for dementia and affects neuroinflammation, brain metabolism, and synaptic function. The kynurenine pathway (KP) gives rise to neuroact...
Kynurenines, Neuropsychiatric Symptoms, and Cognitive Prognosis in Patients with Mild Dementia [0.03%]
轻度痴呆患者犬尿氨酸代谢产物、神经精神症状和认知预后之间的关系
Stein-Erik Hafstad Solvang,Jan Erik Nordrehaug,Dag Aarsland et al.
Stein-Erik Hafstad Solvang et al.
Introduction: Circulating tryptophan (Trp) and its downstream metabolites, the kynurenines, are potentially neuroactive. Consequently, they could be associated with neuropsychiatric symptoms and cognitive prognosis in pat...
Serotonin Syndrome: Pathophysiology, Clinical Features, Management, and Potential Future Directions [0.03%]
血清素综合征：发病机制、临床表现、治疗方法及未来研究方向
William J Scotton,Lisa J Hill,Adrian C Williams et al.
William J Scotton et al.
Serotonin syndrome (SS) (also referred to as serotonin toxicity) is a potentially life-threatening drug-induced toxidrome associated with increased serotonergic activity in both the peripheral (PNS) and central nervous systems (CNS). It is ...
Inhibition of Indoleamine 2,3 Dioxygenase Does Not Improve Cancer-Related Symptoms in a Murine Model of Human Papilloma Virus-Related Head and Neck Cancer [0.03%]
抑制吲哚胺2,3双氧酶不能改善人乳头瘤病毒相关头颈癌小鼠模型的癌症相关症状
Elisabeth G Vichaya,Daniel W Vermeer,David Budac et al.
Elisabeth G Vichaya et al.
The expression of indoleamine 2,3 dioxygenase (IDO) by tumors can contribute to immunotolerance, and IDO induced by inflammation can also increase risk for the development of behavioral alterations. Thus, this study was initiated to determi...