The Effect of Tryptophan 2,3-Dioxygenase Inhibition on Kynurenine Metabolism and Cognitive Function in the APP23 Mouse Model of Alzheimer's Disease [0.03%]
色氨酸2,3-双氧酶抑制对APP23型阿尔兹海默病小鼠犬尿氨酸代谢和认知功能的影响研究
Fjh Sorgdrager,C P van Der Ley,M van Faassen et al.
Fjh Sorgdrager et al.
Alzheimer's disease (AD) is associated with progressive endogenous neurotoxicity and hampered inflammatory regulation. The kynurenine (Kyn) pathway, which is controlled by tryptophan 2,3-dioxygenase (TDO), produces neuroactive and anti-infl...
Saturated Fatty Acid Intake Is Associated With Increased Inflammation, Conversion of Kynurenine to Tryptophan, and Delta-9 Desaturase Activity in Healthy Humans [0.03%]
饱和脂肪酸的摄入与健康人的炎症增加、犬尿酸向色氨酸转化以及脱氢酶活性升高有关
Jade Berg,Neda Seyedsadjadi,Ross Grant
Jade Berg
Saturated fat ingestion has previously been linked to increases in inflammation. However the relationship between saturated fatty acid (SFA) intake and the kynureine:tryptophan ratio ([Kyn]:[Trp]), a marker of inflammation, has not been pre...
In Silico ADME, Metabolism Prediction and Hydrolysis Study of Melatonin Derivatives [0.03%]
基于计算的褪黑素衍生物的ADMET性质、代谢和水解研究
Panyada Panyatip,Nadtanet Nunthaboot,Ploenthip Puthongking
Panyada Panyatip
Melatonin (MLT) is a well-known pineal hormone possessed with remarkable biological activities. However, its low oral bioavailability and high first-pass metabolism rate are important pharmacokinetics problems. Therefore, 5 MLT derivatives ...
Quantification of Plasma Kynurenine Metabolites Following One Bout of Sprint Interval Exercise [0.03%]
一次冲刺间歇运动后血浆犬尿氨酸代谢物的测定
Ada Trepci,Sophie Imbeault,Victoria L Wyckelsma et al.
Ada Trepci et al.
The kynurenine pathway of tryptophan degradation produces several neuroactive metabolites suggested to be involved in a wide variety of diseases and disorders, however, technical challenges in reliably detecting these metabolites hampers cr...
Alteration in Gene Pair Correlations in Tryptophan Metabolism as a Hallmark in Cancer Diagnosis [0.03%]
色氨酸代谢基因偶联相关性变化作为癌症诊断标志物的潜力研究
Meena Kishore Sakharkar,Sarinder Kaur Dhillon,Karthic Rajamanickam et al.
Meena Kishore Sakharkar et al.
Tryptophan metabolism plays essential roles in both immunomodulation and cancer development. Indoleamine 2,3-dioxygenase, a rate-limiting enzyme in the metabolic pathway, is overexpressed in different types of cancer. To get a better unders...
Altered Indoleamine 2,3-Dioxygenase Production and Its Association to Inflammatory Cytokines in Peripheral Blood Mononuclear Cells Culture of Type 2 Diabetes Mellitus [0.03%]
2型糖尿病外周血单个核细胞中色氨酸代谢酶IDO的表达及其与促炎症细胞因子的相关性
Rona Kartika,Heri Wibowo,Dyah Purnamasari et al.
Rona Kartika et al.
Aim: To analyze indoleamine 2,3-dioxygenase (IDO) production in the cell culture supernatant of phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMCs) from type 2 DM (T2DM) patients and investigate...
Abid Bhat,Ananda Staats Pires,Vanessa Tan et al.
Abid Bhat et al.
Sleep has a regulatory role in maintaining metabolic homeostasis and cellular functions. Inadequate sleep time and sleep disorders have become more prevalent in the modern lifestyle. Fragmentation of sleep pattern alters critical intracellu...
The Role of Tryptophan and Tyrosine in Executive Function and Reward Processing [0.03%]
色氨酸和酪氨在执行功能和奖励处理中的作用
Luca Aquili
Luca Aquili
The serotonergic precursor tryptophan and the dopaminergic precursor tyrosine have been shown to be important modulators of mood, behaviour and cognition. Specifically, research on the function of tryptophan has characterised this molecule ...
Effect of Probiotic Administration on Serum Tryptophan Metabolites in Pediatric Type 1 Diabetes Patients [0.03%]
益生菌对1型糖尿病患儿血清色氨酸代谢物的影响
Giada Mondanelli,Elena Orecchini,Claudia Volpi et al.
Giada Mondanelli et al.
Type 1 diabetes (T1D) is characterized by anomalous functioning of the immuno regulatory, tryptophan-catabolic enzyme indoleamine 2,3 dioxygenase 1 (IDO1). In T1D, the levels of kynurenine-the first byproduct of tryptophan degradation via I...
Musthafa Mohamed Essa,Hamdan Hamdan,Saravana Babu Chidambaram et al.
Musthafa Mohamed Essa et al.