An Investigation into the Temporal Reproducibility of Tryptophan Metabolite Networks Among Healthy Adolescents [0.03%]
一项关于色氨酸代谢物网络在健康青少年中时间可重复性的调查研究
Kolade Oluwagbemigun,Andrea Anesi,Gerard Clarke et al.
Kolade Oluwagbemigun et al.
Tryptophan and its bioactive metabolites are associated with health conditions such as systemic inflammation, cardiometabolic diseases, and neurodegenerative disorders. There are dynamic interactions among metabolites of tryptophan. The int...
Blockade of KAT II Facilitates LTP in Kynurenine 3-Monooxygenase Depleted Mice [0.03%]
阻断KAT II可促进犬尿氨酸3-单加氧酶耗竭小鼠的长时程增强效应
Sophie Imbeault,Max Gubert Olivé,Oscar Jungholm et al.
Sophie Imbeault et al.
Excess of brain kynurenic acid (KYNA), a neuroactive metabolite of the kynurenine pathway, is known to elicit cognitive dysfunction. In the present study, we investigated spatial working memory in mice with elevated levels of KYNA, induced ...
Neurotransmitter Precursor Amino Acid Ratios Show Differential, Inverse Correlations with Depression Severity in the Low and High Depression Score Range [0.03%]
低分和高抑郁得分受试者中抑郁症严重程度与神经递质前体氨基酸比率的相关性不同且相反
Katharina Hüfner,Johannes M Giesinger,Johanna M Gostner et al.
Katharina Hüfner et al.
The immunomodulatory capacity of mental stress is one of the basic concepts of psychoneuroimmunology. The current prospective longitudinal study was designed to evaluate the effect of acute mental stress on neurotransmitter precursor amino ...
Improved Voltammetric Determination of Kynurenine at the Nafion Covered Glassy Carbon Electrode - Application in Samples Delivered from Human Cancer Cells [0.03%]
改进的纳芬兰覆盖玻璃碳电极伏安法测定犬尿黑酸的应用及人体癌细胞样品的检测
Ilona Sadok,Katarzyna Tyszczuk-Rotko,Robert Mroczka et al.
Ilona Sadok et al.
Nowadays, development of analytical methods responding to a need for rapid and accurate determination of human metabolites is highly desirable. Herein, an electrochemical method employing a Nafion-coated glassy carbon electrode (Nafion/GCE)...
The Effects of Maternal Interleukin-17A on Social Behavior, Cognitive Function, and Depression-Like Behavior in Mice with Altered Kynurenine Metabolites [0.03%]
母体白细胞介素-17A对改变犬尿酸代谢物小鼠社交行为、认知功能及类似抑郁样行为的影响
Yuki Murakami,Yukio Imamura,Yoshiyuki Kasahara et al.
Yuki Murakami et al.
Viral infection and chronic maternal inflammation during pregnancy are correlated with a higher prevalence of autism spectrum disorder (ASD). However, the pathoetiology of ASD is not fully understood; moreover, the key molecules that can cr...
Plasma Anthranilic Acid and Leptin Levels Predict HAM-D Scores in Depressed Women [0.03%]
血浆扁桃酸和瘦素水平可预测抑郁女性的汉密尔顿抑郁量表(HAM-D)评分
Johann Steiner,Henrik Dobrowolny,Paul C Guest et al.
Johann Steiner et al.
Objectives: Major depressive disorder (MDD) is associated with dysregulations of leptin and tryptophan-kynurenine (Trp-Kyn) (TKP) pathways. Leptin, a pro-inflammatory cytokine, activates Trp conversion into Kyn. However, ...
Marion Falabrègue,Anne-Claire Boschat,Romain Jouffroy et al.
Marion Falabrègue et al.
Low levels of the neurotransmitter serotonin have been associated with the onset of depression. While traditional treatments include antidepressants, physical exercise has emerged as an alternative for patients with depressive disorders. Ye...
Does Exercise Influence Kynurenine/Tryptophan Metabolism and Psychological Outcomes in Persons With Age-Related Diseases? A Systematic Review [0.03%]
锻炼对年龄相关性疾病患者的犬尿酸/色氨酸代谢和心理结果有影响吗？系统回顾性研究
Anthony Lim,Christel Harijanto,Sara Vogrin et al.
Anthony Lim et al.
Background: The kynurenine (KYN) pathway has been implicated in many diseases associated with inflammation and aging ("inflammaging"). Targeting the kynurenine pathway to modify disease outcomes has been trialled pharmaco...
Localization of Indoleamine 2,3-Dioxygenase-1 and Indoleamine 2,3-Dioxygenase-2 at the Human Maternal-Fetal Interface [0.03%]
人母胎界面的吲哚胺2,3双加氧酶1和吲哚胺2,3双加氧酶2的定位
Yoshiki Kudo,Iemasa Koh,Jun Sugimoto
Yoshiki Kudo
Immunohistochemical localization of indoleamine 2,3-dioxygenase-1 and indoleamine 2,3-dioxygenase-2, the first and rate-limiting enzyme in tryptophan metabolism along the kynurenine pathway, has been studied in order to better understand th...
Sodium Butyrate and Indole-3-propionic Acid Prevent the Increase of Cytokines and Kynurenine Levels in LPS-induced Human Primary Astrocytes [0.03%]
丁酸钠和色氨丙酸诱导的LPS人原代星形胶质细胞中细胞因子及犬尿素水平升高现象的研究
Michelle L Garcez,Vanessa X Tan,Benjamin Heng et al.
Michelle L Garcez et al.
The crosstalk between central nervous system (CNS) and gut microbiota plays key roles in neuroinflammation and chronic immune activation that are common features of all neurodegenerative diseases. Imbalance in the microbiota can lead to an ...