Social and Biological Parameters Involved in Suicide Ideation During the COVID-19 Pandemic: A Narrative Review [0.03%]
新冠疫情下自杀想法相关的社会及生物学参数：综述性文章
Chenthamara Dhrisya,Murugan Prasathkumar,Robert Becky et al.
Chenthamara Dhrisya et al.
Fear is an indispensable characteristic of any infectious disease, and the alarm will be further amplified when the infection spreads uncontrollable, unpredictable, and global. The novel corona virus (SARS CoV-2) lead Covid-19, has been dec...
David B Ramsden,Rosemary H Waring,David J Barlow et al.
David B Ramsden et al.
Over the past decade, the roles of nicotinamide N-methyltransferase and its product 1-methyl nicotinamide have emerged from playing merely minor roles in phase 2 xenobiotic metabolism as actors in some of the most important scenes of human ...
Intestinal Dysbiosis, the Tryptophan Pathway and Nonalcoholic Steatohepatitis [0.03%]
肠道菌群失调、色氨酸代谢途径与非酒精性脂肪肝病
Jiezhong Chen,Luis Vitetta,Jeremy D Henson et al.
Jiezhong Chen et al.
Non-alcoholic fatty liver disease (NAFLD) progresses from simple steatosis to steatohepatitis (NASH), which may then progress to the development of cirrhosis and hepatocarcinoma. NASH is characterized by both steatosis and inflammation. Con...
Kynurenine and Anthranilic Acid in the Peritoneum Correlate With the Stage of Gastric Cancer Disease [0.03%]
胃癌患者腹水中犬尿酸和邻氨基苯甲酸的浓度与肿瘤负荷相关性研究
Katarzyna Gęca,Karol Rawicz-Pruszyński,Radosław Mlak et al.
Katarzyna Gęca et al.
Background: This study aimed to assess the importance of selected kynurenines measured in peritoneal fluid, lavage washings, and blood serum in patients with advanced gastric cancer (GC) based on the clinical and patholog...
Association Between Tryptophan Metabolites, Physical Performance, and Frailty in Older Persons [0.03%]
色氨酸代谢产物、身体表现和老年人的脆弱性之间的关系
Ahmed Al Saedi,Sharron Chow,Sara Vogrin et al.
Ahmed Al Saedi et al.
Frailty is defined as a syndrome of physiological decline in late life, characterized by marked vulnerability to adverse health outcomes. A robust biomarker for frailty is still lacking. Tryptophan (TRP) metabolism through the kynurenine pa...
Activation of the Kynurenine Pathway and Production of Inflammatory Cytokines by Astrocytes and Microglia Infected With Neospora caninum [0.03%]
新猪脑虫感染星形胶质细胞和小胶质细胞活化犬尿素途径及促炎症因子的产生
Deivison Silva Argolo,Julita Maria Pereira Borges,Luciana Dos Santos Freitas et al.
Deivison Silva Argolo et al.
In the central nervous system, astrocytes and microglia contribute to homeostasis, regulating the immune response to infectious agents. Neospora caninum is an obligate intracellular protozoan that infects different animal species and it is ...
Differential Effect of Non-Purified and Semi-Purified Standard Diets on Kynurenine and Peripheral Metabolites in Male C57BL/6J Mice [0.03%]
非精制和半精制剂型标准饲料对雄性C57BL/6J小鼠犬尿酸及外周代谢物影响的差异性研究
Yuhei Yajima,Alato Okuno,Isamu Nakamura et al.
Yuhei Yajima et al.
The kynurenine (Kyn) pathway plays crucial roles in several inflammation-induced disorders such as depression. In this study, we measured Kyn and other related molecules in the blood plasma, brain, and urine of male C57BL/6J mice (B6) fed n...
Indoleamine 2,3-Dioxygenase-1 Expression is Changed During Bladder Cancer Cell Invasion [0.03%]
色氨酸2，3-双氧酶-1在膀胱癌细胞侵袭过程中的变化研究
Hellen Joyce Sousa Pereira Santos,Luiz Henrique Gomes Matheus,Aline Silva et al.
Hellen Joyce Sousa Pereira Santos et al.
The severity of the bladder carcinoma (BC) is directly linked to cell invasion and metastasis. Indoleamine 2,3-dioxygenase-1 (IDO-1) is an INF-γ-induced immunomodulating enzyme that has been linked to the cancer cell invasiveness. Because ...
Temporary Intermediates of L-Trp Along the Reaction Pathway of Human Indoleamine 2,3-Dioxygenase 1 and Identification of an Exo Site [0.03%]
人源吲哚胺2,3双加氧酶1反应途径中L-色氨酸暂时性中间体的鉴定及exo作用位点识别
Manon Mirgaux,Laurence Leherte,Johan Wouters
Manon Mirgaux
Protein dynamics governs most of the fundamental processes in the human body. Particularly, the dynamics of loops located near an active site can be involved in the positioning of the substrate and the reaction mechanism. The understanding ...
Effects of Psychological and Physical Stress on Oxidative Stress, Serotonin, and Fatigue in Young Females Induced by Objective Structured Clinical Examination: Pilot Study of u-8-OHdG, u-5HT, and s-HHV-6 [0.03%]
心理和身体压力对年轻女性氧化应激，血清素和疲劳的影响：通过客观结构化临床考试进行u-8-OHdG，u-5HT和s-HHV-6的初步研究
Tadayuki Iida,Yasuhiro Ito,Miho Kanazashi et al.
Tadayuki Iida et al.
Background: To establish a method to prevent and manage fatigue caused by psychological and physical stress in young females, early detection factors, such as understanding of fatigue and causes of psychological and physi...