The Effects of Maternal Interleukin-17A on Social Behavior, Cognitive Function, and Depression-Like Behavior in Mice with Altered Kynurenine Metabolites [0.03%]
母体白细胞介素-17A对改变犬尿酸代谢物小鼠社交行为、认知功能及类似抑郁样行为的影响
Yuki Murakami,Yukio Imamura,Yoshiyuki Kasahara et al.
Yuki Murakami et al.
Viral infection and chronic maternal inflammation during pregnancy are correlated with a higher prevalence of autism spectrum disorder (ASD). However, the pathoetiology of ASD is not fully understood; moreover, the key molecules that can cr...
Plasma Anthranilic Acid and Leptin Levels Predict HAM-D Scores in Depressed Women [0.03%]
血浆扁桃酸和瘦素水平可预测抑郁女性的汉密尔顿抑郁量表(HAM-D)评分
Johann Steiner,Henrik Dobrowolny,Paul C Guest et al.
Johann Steiner et al.
Objectives: Major depressive disorder (MDD) is associated with dysregulations of leptin and tryptophan-kynurenine (Trp-Kyn) (TKP) pathways. Leptin, a pro-inflammatory cytokine, activates Trp conversion into Kyn. However, ...
Marion Falabrègue,Anne-Claire Boschat,Romain Jouffroy et al.
Marion Falabrègue et al.
Low levels of the neurotransmitter serotonin have been associated with the onset of depression. While traditional treatments include antidepressants, physical exercise has emerged as an alternative for patients with depressive disorders. Ye...
Does Exercise Influence Kynurenine/Tryptophan Metabolism and Psychological Outcomes in Persons With Age-Related Diseases? A Systematic Review [0.03%]
锻炼对年龄相关性疾病患者的犬尿酸/色氨酸代谢和心理结果有影响吗？系统回顾性研究
Anthony Lim,Christel Harijanto,Sara Vogrin et al.
Anthony Lim et al.
Background: The kynurenine (KYN) pathway has been implicated in many diseases associated with inflammation and aging ("inflammaging"). Targeting the kynurenine pathway to modify disease outcomes has been trialled pharmaco...
Localization of Indoleamine 2,3-Dioxygenase-1 and Indoleamine 2,3-Dioxygenase-2 at the Human Maternal-Fetal Interface [0.03%]
人母胎界面的吲哚胺2,3双加氧酶1和吲哚胺2,3双加氧酶2的定位
Yoshiki Kudo,Iemasa Koh,Jun Sugimoto
Yoshiki Kudo
Immunohistochemical localization of indoleamine 2,3-dioxygenase-1 and indoleamine 2,3-dioxygenase-2, the first and rate-limiting enzyme in tryptophan metabolism along the kynurenine pathway, has been studied in order to better understand th...
Sodium Butyrate and Indole-3-propionic Acid Prevent the Increase of Cytokines and Kynurenine Levels in LPS-induced Human Primary Astrocytes [0.03%]
丁酸钠和色氨丙酸诱导的LPS人原代星形胶质细胞中细胞因子及犬尿素水平升高现象的研究
Michelle L Garcez,Vanessa X Tan,Benjamin Heng et al.
Michelle L Garcez et al.
The crosstalk between central nervous system (CNS) and gut microbiota plays key roles in neuroinflammation and chronic immune activation that are common features of all neurodegenerative diseases. Imbalance in the microbiota can lead to an ...
The Effect of Tryptophan 2,3-Dioxygenase Inhibition on Kynurenine Metabolism and Cognitive Function in the APP23 Mouse Model of Alzheimer's Disease [0.03%]
色氨酸2,3-双氧酶抑制对APP23型阿尔兹海默病小鼠犬尿氨酸代谢和认知功能的影响研究
Fjh Sorgdrager,C P van Der Ley,M van Faassen et al.
Fjh Sorgdrager et al.
Alzheimer's disease (AD) is associated with progressive endogenous neurotoxicity and hampered inflammatory regulation. The kynurenine (Kyn) pathway, which is controlled by tryptophan 2,3-dioxygenase (TDO), produces neuroactive and anti-infl...
Saturated Fatty Acid Intake Is Associated With Increased Inflammation, Conversion of Kynurenine to Tryptophan, and Delta-9 Desaturase Activity in Healthy Humans [0.03%]
饱和脂肪酸的摄入与健康人的炎症增加、犬尿酸向色氨酸转化以及脱氢酶活性升高有关
Jade Berg,Neda Seyedsadjadi,Ross Grant
Jade Berg
Saturated fat ingestion has previously been linked to increases in inflammation. However the relationship between saturated fatty acid (SFA) intake and the kynureine:tryptophan ratio ([Kyn]:[Trp]), a marker of inflammation, has not been pre...
In Silico ADME, Metabolism Prediction and Hydrolysis Study of Melatonin Derivatives [0.03%]
基于计算的褪黑素衍生物的ADMET性质、代谢和水解研究
Panyada Panyatip,Nadtanet Nunthaboot,Ploenthip Puthongking
Panyada Panyatip
Melatonin (MLT) is a well-known pineal hormone possessed with remarkable biological activities. However, its low oral bioavailability and high first-pass metabolism rate are important pharmacokinetics problems. Therefore, 5 MLT derivatives ...
Quantification of Plasma Kynurenine Metabolites Following One Bout of Sprint Interval Exercise [0.03%]
一次冲刺间歇运动后血浆犬尿氨酸代谢物的测定
Ada Trepci,Sophie Imbeault,Victoria L Wyckelsma et al.
Ada Trepci et al.
The kynurenine pathway of tryptophan degradation produces several neuroactive metabolites suggested to be involved in a wide variety of diseases and disorders, however, technical challenges in reliably detecting these metabolites hampers cr...