Prophylactic and Therapeutic Effect of Kynurenine for Experimental Autoimmune Encephalomyelitis (EAE) Disease [0.03%]
犬尿酸预防和治疗实验性自身免疫性脑脊髓炎(EAE)疾病的效应
Gayathri Sundaram,Alban Bessede,David Gilot et al.
Gayathri Sundaram et al.
Background: The essential amino acid, tryptophan, is predominantly metabolised through the kynurenine pathway (KP) to generate kynurenine, an aryl-hydrocarbon receptor (AhR) pro-ligand that exerts its effects in a ligand-...
Learning Deficits Induced by High-Calorie Feeding in the Rat are Associated With Impaired Brain Kynurenine Pathway Metabolism [0.03%]
高热量喂养诱导的大鼠学习缺陷与大脑犬尿酸代谢障碍有关
Carla Elena Mezo-González,Amran Daher Abdi,Luis Antonio Reyes-Castro et al.
Carla Elena Mezo-González et al.
In addition to be a primary risk factor for type 2 diabetes and cardiovascular disease, obesity is associated with learning disabilities. Here we examined whether a dysregulation of the kynurenine pathway (KP) of tryptophan (Trp) metabolism...
Moein Ala,Seyed Parsa Eftekhar
Moein Ala
Kynurenine pathway is the main route of tryptophan metabolism and produces several metabolites with various biologic properties. It has been uncovered that several cardiovascular diseases are associated with the overactivation of kynurenine...
Behavioral, Hormonal, and Serotonergic Responses to Different Restricted Feeding Schedules in Rats [0.03%]
不同限制喂食方案下大鼠的行为、激素和血清素反应
Raheel Saeed,Khalid Mahmood,Sadia Basharat Ali et al.
Raheel Saeed et al.
To determine the effect of long-term restricted feeding schedules on behavior, serotonergic responses, and neuro-endocrine functions, metabolism of serotonin (5-HT) in the striatum, expression of serotonin-1A (5-HT1A) auto-receptor in the r...
Tryptophan and Biogenic Amines in the Differentiation and Quality of Honey [0.03%]
色氨酸和生物胺在蜂蜜的分类和质量中的作用
Cristine Vanz Borges,Aline Nunes,Vladimir Eliodoro Costa et al.
Cristine Vanz Borges et al.
Honey is a natural product with beneficial properties to health and has different characteristics depending on the region of production and collection, flowering, and climate. The presence of precursor amino acids of- and biogenic amines ca...
Plasma Kynurenine: A Promising Marker for the Assessment of Renal Functions [0.03%]
血浆犬尿酸可能成为肾功能损伤的生物标志物
Fatimah Brekdar,Muhammed Imad Khayat,Afraa Zrieki
Fatimah Brekdar
Background: Chronic kidney disease (CKD) is a worldwide issue due to the high prevalence and the serious complications, including death. Kidney functions are routinely evaluated by measuring creatinine levels, which are i...
Alterations in Tryptophan Metabolism Affect Vascular Functions: Connected to Ageing Population Vulnerability to COVID-19 Infection? [0.03%]
色氨酸代谢改变影响血管功能：与年龄人口易感染新冠肺炎的脆弱性有关吗？
Arehally M Mahalakshmi,Shasthara Paneyala,Bipul Ray et al.
Arehally M Mahalakshmi et al.
The Kynurenine Pathway and Polycystic Ovary Syndrome: Inflammation as a Common Denominator [0.03%]
犬尿酸途径与多囊卵巢综合征：炎症作为共同因素
Filip Jovanovic,Aboorva Sudhakar,Nebojsa Nick Knezevic
Filip Jovanovic
Polycystic ovary syndrome (PCOS) is a complex metabolic disorder commonly seen in females of reproductive age. The pathophysiology of PCOS is multifactorial and includes dysfunction in ovarian steroidogenesis and folliculogenesis, impaired ...
Loss of Indoleamine-2,3-Dioxygenase-1 (IDO1) in Knockout Mice Does Not Affect the Development of Skin Lesions in the Imiquimod-Induced Mouse Model of Psoriasis [0.03%]
诱导型一氧化氮合酶-1(IDO1)敲除小鼠在咪喹莫德诱导的银屑病小鼠模型中对皮肤病变的发展没有影响
Vivek Choudhary,Etsubdenk Ajebo,Rawipan Uaratanawong et al.
Vivek Choudhary et al.
Indoleamine-2,3-dioxygenase (IDO) degrades the essential amino acid tryptophan resulting in tryptophan depletion and the accumulation of catabolites such as kynurenine. The expression/activity of IDO in various cells, including macrophages ...
Kynurenine Pathway in Chronic Kidney Disease: What's Old, What's New, and What's Next? [0.03%]
慢性肾脏病中的犬尿氨酸途径：哪些是已知的，哪些是新的，以及未来的研究方向是什么？
Adrian Mor,Bartlomiej Kalaska,Dariusz Pawlak
Adrian Mor
Impaired kidney function and increased inflammatory process occurring in the course of Chronic Kidney Disease (CKD) contribute to the development of complex amino-acid alterations. The essential amino-acid tryptophan (TRP) undergoes extensi...