Association Between Tryptophan Metabolites, Physical Performance, and Frailty in Older Persons [0.03%]
色氨酸代谢产物、身体表现和老年人的脆弱性之间的关系
Ahmed Al Saedi,Sharron Chow,Sara Vogrin et al.
Ahmed Al Saedi et al.
Frailty is defined as a syndrome of physiological decline in late life, characterized by marked vulnerability to adverse health outcomes. A robust biomarker for frailty is still lacking. Tryptophan (TRP) metabolism through the kynurenine pa...
Activation of the Kynurenine Pathway and Production of Inflammatory Cytokines by Astrocytes and Microglia Infected With Neospora caninum [0.03%]
新猪脑虫感染星形胶质细胞和小胶质细胞活化犬尿素途径及促炎症因子的产生
Deivison Silva Argolo,Julita Maria Pereira Borges,Luciana Dos Santos Freitas et al.
Deivison Silva Argolo et al.
In the central nervous system, astrocytes and microglia contribute to homeostasis, regulating the immune response to infectious agents. Neospora caninum is an obligate intracellular protozoan that infects different animal species and it is ...
Differential Effect of Non-Purified and Semi-Purified Standard Diets on Kynurenine and Peripheral Metabolites in Male C57BL/6J Mice [0.03%]
非精制和半精制剂型标准饲料对雄性C57BL/6J小鼠犬尿酸及外周代谢物影响的差异性研究
Yuhei Yajima,Alato Okuno,Isamu Nakamura et al.
Yuhei Yajima et al.
The kynurenine (Kyn) pathway plays crucial roles in several inflammation-induced disorders such as depression. In this study, we measured Kyn and other related molecules in the blood plasma, brain, and urine of male C57BL/6J mice (B6) fed n...
Indoleamine 2,3-Dioxygenase-1 Expression is Changed During Bladder Cancer Cell Invasion [0.03%]
色氨酸2，3-双氧酶-1在膀胱癌细胞侵袭过程中的变化研究
Hellen Joyce Sousa Pereira Santos,Luiz Henrique Gomes Matheus,Aline Silva et al.
Hellen Joyce Sousa Pereira Santos et al.
The severity of the bladder carcinoma (BC) is directly linked to cell invasion and metastasis. Indoleamine 2,3-dioxygenase-1 (IDO-1) is an INF-γ-induced immunomodulating enzyme that has been linked to the cancer cell invasiveness. Because ...
Temporary Intermediates of L-Trp Along the Reaction Pathway of Human Indoleamine 2,3-Dioxygenase 1 and Identification of an Exo Site [0.03%]
人源吲哚胺2,3双加氧酶1反应途径中L-色氨酸暂时性中间体的鉴定及exo作用位点识别
Manon Mirgaux,Laurence Leherte,Johan Wouters
Manon Mirgaux
Protein dynamics governs most of the fundamental processes in the human body. Particularly, the dynamics of loops located near an active site can be involved in the positioning of the substrate and the reaction mechanism. The understanding ...
Effects of Psychological and Physical Stress on Oxidative Stress, Serotonin, and Fatigue in Young Females Induced by Objective Structured Clinical Examination: Pilot Study of u-8-OHdG, u-5HT, and s-HHV-6 [0.03%]
心理和身体压力对年轻女性氧化应激，血清素和疲劳的影响：通过客观结构化临床考试进行u-8-OHdG，u-5HT和s-HHV-6的初步研究
Tadayuki Iida,Yasuhiro Ito,Miho Kanazashi et al.
Tadayuki Iida et al.
Background: To establish a method to prevent and manage fatigue caused by psychological and physical stress in young females, early detection factors, such as understanding of fatigue and causes of psychological and physi...
An Investigation into the Temporal Reproducibility of Tryptophan Metabolite Networks Among Healthy Adolescents [0.03%]
一项关于色氨酸代谢物网络在健康青少年中时间可重复性的调查研究
Kolade Oluwagbemigun,Andrea Anesi,Gerard Clarke et al.
Kolade Oluwagbemigun et al.
Tryptophan and its bioactive metabolites are associated with health conditions such as systemic inflammation, cardiometabolic diseases, and neurodegenerative disorders. There are dynamic interactions among metabolites of tryptophan. The int...
Blockade of KAT II Facilitates LTP in Kynurenine 3-Monooxygenase Depleted Mice [0.03%]
阻断KAT II可促进犬尿氨酸3-单加氧酶耗竭小鼠的长时程增强效应
Sophie Imbeault,Max Gubert Olivé,Oscar Jungholm et al.
Sophie Imbeault et al.
Excess of brain kynurenic acid (KYNA), a neuroactive metabolite of the kynurenine pathway, is known to elicit cognitive dysfunction. In the present study, we investigated spatial working memory in mice with elevated levels of KYNA, induced ...
Neurotransmitter Precursor Amino Acid Ratios Show Differential, Inverse Correlations with Depression Severity in the Low and High Depression Score Range [0.03%]
低分和高抑郁得分受试者中抑郁症严重程度与神经递质前体氨基酸比率的相关性不同且相反
Katharina Hüfner,Johannes M Giesinger,Johanna M Gostner et al.
Katharina Hüfner et al.
The immunomodulatory capacity of mental stress is one of the basic concepts of psychoneuroimmunology. The current prospective longitudinal study was designed to evaluate the effect of acute mental stress on neurotransmitter precursor amino ...
Improved Voltammetric Determination of Kynurenine at the Nafion Covered Glassy Carbon Electrode - Application in Samples Delivered from Human Cancer Cells [0.03%]
改进的纳芬兰覆盖玻璃碳电极伏安法测定犬尿黑酸的应用及人体癌细胞样品的检测
Ilona Sadok,Katarzyna Tyszczuk-Rotko,Robert Mroczka et al.
Ilona Sadok et al.
Nowadays, development of analytical methods responding to a need for rapid and accurate determination of human metabolites is highly desirable. Herein, an electrochemical method employing a Nafion-coated glassy carbon electrode (Nafion/GCE)...