Determination of Picolinic Acid by HPLC Coupled With Postcolumn Photo Irradiation Using Zinc Acetate as a Fluorescent Derivatization Reagent [0.03%]
采用乙酸锌作为衍生化试剂的高效液相色谱-柱后光照射法测定吡啶甲酸
Ken-Ichi Mawatari,Yuika Tanikawa,Makoto Yasuda et al.
Ken-Ichi Mawatari et al.
For the fluorometric determination of picolinic acid in human serum, HPLC-postcolumn UV irradiation using zinc acetate has been developed. Picolinic acid in serum sample was separated on a Capcell Pak C18. The mobile phase consisted of 0.1 ...
Interferon-gamma Mediated Metabolic Pathways in Hospitalized Patients During Acute and Reconvalescent COVID-19 [0.03%]
住院COVID-19患者急性期和恢复期的干扰素γ介导的代谢途径
Mario Gietl,Francesco Burkert,Stefanie Seiwald et al.
Mario Gietl et al.
Background: Fatigue, sleep disturbance, and neurological symptoms during and after COVID-19 are common and might be associated with inflammation-induced changes in tryptophan (Trp) and phenylalanine (Phe) metabolism. ...
Endothelial Indoleamine-2,3-Dioxygenase-1 is not Critically Involved in Regulating Antitumor Immunity in the Central Nervous System [0.03%]
中枢神经系统内皮细胞色氨酸酶IDO不参与抗肿瘤免疫反应
A P Abu Hejleh,K Huck,K Jähne et al.
A P Abu Hejleh et al.
The vascular niche of malignant gliomas is a key compartment that shapes the immunosuppressive brain tumor microenvironment (TME). The blood-brain-barrier (BBB) consisting of specialized endothelial cells (ECs) and perivascular cells forms ...
Modulation of Indoleamine 2,3-Dioxygenase 1 During Inflammatory Bowel Disease Activity in Humans and Mice [0.03%]
人类和小鼠炎症性肠病活动期间调节吲哚胺2,3-双加氧酶1
Elisa Proietti,Renske W M Pauwels,Annemarie C de Vries et al.
Elisa Proietti et al.
Background and aims: Indoleamine 2,3 dioxygenase-1 (IDO1), a key enzyme in tryptophan metabolism, is strongly up-regulated both in human inflammatory bowel disease (IBD) and animal models of colitis, however its role in t...
Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase [0.03%]
吲哚胺2,3-双加氧酶1和色氨酸2,3-双加氧酶的新型双重抑制剂的鉴定与特征分析
Saeko Yoshioka,Tomonori Ikeda,Sogo Fukuchi et al.
Saeko Yoshioka et al.
Kynurenine (Kyn), a metabolite of tryptophan (Trp), is a key regulator of mammal immune responses such as cancer immune tolerance. Indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO) are main enzymes regulating the first ...
The Role of the Kynurenine Pathway in the (Patho) physiology of Maternal Pregnancy and Fetal Outcomes: A Systematic Review [0.03%]
犬尿氨酸途径在母体妊娠和胎儿结局的(病理)生理中的作用：系统回顾
Sofie Km van Zundert,Michelle Broekhuizen,Ashley Jp Smit et al.
Sofie Km van Zundert et al.
Introduction: Tryptophan is the precursor of kynurenine pathway (KP) metabolites which regulate immune tolerance, energy metabolism, and vascular tone. Since these processes are important during pregnancy, changes in KP m...
Temporal Profile of Kynurenine Pathway Metabolites in a Rodent Model of Autosomal Recessive Polycystic Kidney Disease [0.03%]
常染色体隐性多囊肾病啮齿动物模型中康宁通路代谢物的时间分布特点
Ananda Staats Pires,Shabarni Gupta,Sean A Barton et al.
Ananda Staats Pires et al.
Autosomal recessive polycystic kidney disease (ARPKD) is an early onset genetic disorder characterized by numerous renal cysts resulting in end stage renal disease. Our study aimed to determine if metabolic reprogramming and tryptophan (Trp...
Dietary Hesperidin Suppresses Lipopolysaccharide-Induced Inflammation in Male Mice [0.03%]
饮食中的芸香苷可通过抑制脂多糖诱导的小鼠肠炎反应来减少全身性炎症响应
Mizuho Sato,Alato Okuno,Keita Ishisono et al.
Mizuho Sato et al.
Depressive disorders are partially attributed to chronic inflammation associated with the tryptophan (Trp)-kynurenine (Kyn) pathway. Recent evidence suggests that anti-inflammatory agents may reduce the risk of depression. The present study...
Abdulla A-B Badawy,Gilles J Guillemin
Abdulla A-B Badawy
Major species differences in tryptophan (Trp) metabolism and disposition exist with important physiological, functional and toxicity implications. Unlike mammalian and other species in which plasma Trp exists largely bound to albumin, teleo...
Microbiome-Related Indole and Serotonin Metabolites are Linked to Inflammation and Psychiatric Symptoms in People Living with HIV [0.03%]
与HIV阳性人群中的炎症和精神症状相关的肠道微生物群相关吲哚和血清素代谢物
Nadira Vadaq,Yue Zhang,Elise Meeder et al.
Nadira Vadaq et al.
Background: People living with HIV (PLHIV) exhibit dysregulation of tryptophan metabolism. Altered gut microbiome composition in PLHIV might be involved. Mechanistic consequences within the 3 major tryptophan metabolism p...