Funda Orhan,Lilly Schwieler,Göran Engberg et al.
Funda Orhan et al.
In recent years, kynurenine metabolites generated by tryptophan catabolism have gained increasing attention in the context of brain diseases. The question of importance is whether there is a relationship between peripheral and central level...
Fetal Sex as Moderating Factor for the Relationship Between Maternal Childhood Trauma and Salivary Kynurenic Acid and Tryptophan in Pregnancy: A Pilot Study [0.03%]
胎儿性别在调节童年创伤与妊娠期间唾液苦杏仁酸和色氨酸关系中的作用：一项初步研究
Bruno Pedraz-Petrozzi,Eva Kathrin Lamadé,Marta Marszalek-Grabska et al.
Bruno Pedraz-Petrozzi et al.
Traumatic experiences and fetal development influence tryptophan (TRP) and its neuroactive byproduct, kynurenic acid (KYNA). Maternal TRP metabolite levels during pregnancy vary by fetal sex, with higher concentrations in mothers carrying m...
Gregory Oxenkrug,Brent Forester
Gregory Oxenkrug
Introduction: Limited clinical efficiency of current medications warrants search for new antipsychotic agents. Deorphanized G-protein coupled receptor (GPR)109A has not attracted much of attention of schizophrenia researc...
Guillaume Pamart,Philippe Gosset,Olivier Le Rouzic et al.
Guillaume Pamart et al.
The kynurenine pathway is the primary route for tryptophan catabolism and has received increasing attention as its association with inflammation and the immune system has become more apparent. This review provides a broad overview of the ky...
Urine Metabolite Analysis to Identify Pathomechanisms of Long COVID: A Pilot Study [0.03%]
尿液代谢物分析以识别长期COVID的病理机制：一项初步研究
Maja Taenzer,Judith Löffler-Ragg,Andrea Schroll et al.
Maja Taenzer et al.
Background: Around 10% of people who had COVID-9 infection suffer from persistent symptoms such as fatigue, dyspnoea, chest pain, arthralgia/myalgia, sleep disturbances, cognitive dysfunction and impairment of mental heal...
Stability Studies of Kynurenine Pathway Metabolites in Blood Components Define Optimal Blood Processing Conditions [0.03%]
血制品中的犬尿酸代谢物稳定性研究确定了最佳的血液处理条件
Benjamin Heng,Ananda Staats Pires,Sharron Chow et al.
Benjamin Heng et al.
The kynurenine pathway (KP) is the main pathway of tryptophan (TRP) metabolism that generates energy for multiple cellular processes. The activity of this pathway has been shown to be dysregulated in multiple human diseases. The resultant m...
Normative Data on Serum and Plasma Tryptophan and Kynurenine Concentrations from 8089 Individuals Across 120 Studies: A Systematic Review and Meta-Analysis [0.03%]
8089例个体横跨120项研究的血清和血浆色氨酸及犬尿酸浓度的文献系统综述与荟萃分析(normative数据)
Najwa-Joelle Metri,Ali S Butt,Ava Murali et al.
Najwa-Joelle Metri et al.
In this systematic review and meta-analysis, a normative dataset is generated from the published literature on the kynurenine pathway in control participants extracted from case-control and methodological validation studies. Study character...
The Role of the Kynurenine/AhR Pathway in Diseases Related to Metabolism and Cancer [0.03%]
犬尿酸/AhR通路在代谢和癌症相关疾病中的作用
Amir Shadboorestan,Meriem Koual,Julien Dairou et al.
Amir Shadboorestan et al.
The Aryl hydrocarbon receptor (AhR) is a xenobiotic and endobiotic receptor, which regulates many cellular processes from contaminant metabolism to immunomodulation. Consequently, it is also involved in pathophysiological pathways and now r...
Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation [0.03%]
循环宿主和微生物色氨酸代谢物对芳香烃受体活化的贡献
Ethan W Morgan,Fangcong Dong,Andrew J Annalora et al.
Ethan W Morgan et al.
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that plays an integral role in homeostatic maintenance by regulating cellular functions such as cellular differentiation, metabolism, barrier function, and immun...
Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback [0.03%]
内源性色氨酸衍生的Ah受体配体与CYP1A1/1B1依赖性的负反馈调节无关
Fangcong Dong,Andrew J Annalora,Iain A Murray et al.
Fangcong Dong et al.
The aryl hydrocarbon receptor (AHR) exerts major roles in xenobiotic metabolism, and in immune and barrier tissue homeostasis. How AHR activity is regulated by the availability of endogenous ligands is poorly understood. Potent AHR ligands ...