Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase [0.03%]
吲哚胺2,3-双加氧酶1和色氨酸2,3-双加氧酶的新型双重抑制剂的鉴定与特征分析
Saeko Yoshioka,Tomonori Ikeda,Sogo Fukuchi et al.
Saeko Yoshioka et al.
Kynurenine (Kyn), a metabolite of tryptophan (Trp), is a key regulator of mammal immune responses such as cancer immune tolerance. Indoleamine-2,3-dioxygenase (IDO) and tryptophan-2,3-dioxygenase (TDO) are main enzymes regulating the first ...
The Role of the Kynurenine Pathway in the (Patho) physiology of Maternal Pregnancy and Fetal Outcomes: A Systematic Review [0.03%]
犬尿氨酸途径在母体妊娠和胎儿结局的(病理)生理中的作用：系统回顾
Sofie Km van Zundert,Michelle Broekhuizen,Ashley Jp Smit et al.
Sofie Km van Zundert et al.
Introduction: Tryptophan is the precursor of kynurenine pathway (KP) metabolites which regulate immune tolerance, energy metabolism, and vascular tone. Since these processes are important during pregnancy, changes in KP m...
Temporal Profile of Kynurenine Pathway Metabolites in a Rodent Model of Autosomal Recessive Polycystic Kidney Disease [0.03%]
常染色体隐性多囊肾病啮齿动物模型中康宁通路代谢物的时间分布特点
Ananda Staats Pires,Shabarni Gupta,Sean A Barton et al.
Ananda Staats Pires et al.
Autosomal recessive polycystic kidney disease (ARPKD) is an early onset genetic disorder characterized by numerous renal cysts resulting in end stage renal disease. Our study aimed to determine if metabolic reprogramming and tryptophan (Trp...
Dietary Hesperidin Suppresses Lipopolysaccharide-Induced Inflammation in Male Mice [0.03%]
饮食中的芸香苷可通过抑制脂多糖诱导的小鼠肠炎反应来减少全身性炎症响应
Mizuho Sato,Alato Okuno,Keita Ishisono et al.
Mizuho Sato et al.
Depressive disorders are partially attributed to chronic inflammation associated with the tryptophan (Trp)-kynurenine (Kyn) pathway. Recent evidence suggests that anti-inflammatory agents may reduce the risk of depression. The present study...
Abdulla A-B Badawy,Gilles J Guillemin
Abdulla A-B Badawy
Major species differences in tryptophan (Trp) metabolism and disposition exist with important physiological, functional and toxicity implications. Unlike mammalian and other species in which plasma Trp exists largely bound to albumin, teleo...
Microbiome-Related Indole and Serotonin Metabolites are Linked to Inflammation and Psychiatric Symptoms in People Living with HIV [0.03%]
与HIV阳性人群中的炎症和精神症状相关的肠道微生物群相关吲哚和血清素代谢物
Nadira Vadaq,Yue Zhang,Elise Meeder et al.
Nadira Vadaq et al.
Background: People living with HIV (PLHIV) exhibit dysregulation of tryptophan metabolism. Altered gut microbiome composition in PLHIV might be involved. Mechanistic consequences within the 3 major tryptophan metabolism p...
Prophylactic and Therapeutic Effect of Kynurenine for Experimental Autoimmune Encephalomyelitis (EAE) Disease [0.03%]
犬尿酸预防和治疗实验性自身免疫性脑脊髓炎(EAE)疾病的效应
Gayathri Sundaram,Alban Bessede,David Gilot et al.
Gayathri Sundaram et al.
Background: The essential amino acid, tryptophan, is predominantly metabolised through the kynurenine pathway (KP) to generate kynurenine, an aryl-hydrocarbon receptor (AhR) pro-ligand that exerts its effects in a ligand-...
Learning Deficits Induced by High-Calorie Feeding in the Rat are Associated With Impaired Brain Kynurenine Pathway Metabolism [0.03%]
高热量喂养诱导的大鼠学习缺陷与大脑犬尿酸代谢障碍有关
Carla Elena Mezo-González,Amran Daher Abdi,Luis Antonio Reyes-Castro et al.
Carla Elena Mezo-González et al.
In addition to be a primary risk factor for type 2 diabetes and cardiovascular disease, obesity is associated with learning disabilities. Here we examined whether a dysregulation of the kynurenine pathway (KP) of tryptophan (Trp) metabolism...
Moein Ala,Seyed Parsa Eftekhar
Moein Ala
Kynurenine pathway is the main route of tryptophan metabolism and produces several metabolites with various biologic properties. It has been uncovered that several cardiovascular diseases are associated with the overactivation of kynurenine...
Behavioral, Hormonal, and Serotonergic Responses to Different Restricted Feeding Schedules in Rats [0.03%]
不同限制喂食方案下大鼠的行为、激素和血清素反应
Raheel Saeed,Khalid Mahmood,Sadia Basharat Ali et al.
Raheel Saeed et al.
To determine the effect of long-term restricted feeding schedules on behavior, serotonergic responses, and neuro-endocrine functions, metabolism of serotonin (5-HT) in the striatum, expression of serotonin-1A (5-HT1A) auto-receptor in the r...