Urine Metabolite Analysis to Identify Pathomechanisms of Long COVID: A Pilot Study [0.03%]
尿液代谢物分析以识别长期COVID的病理机制：一项初步研究
Maja Taenzer,Judith Löffler-Ragg,Andrea Schroll et al.
Maja Taenzer et al.
Background: Around 10% of people who had COVID-9 infection suffer from persistent symptoms such as fatigue, dyspnoea, chest pain, arthralgia/myalgia, sleep disturbances, cognitive dysfunction and impairment of mental heal...
Stability Studies of Kynurenine Pathway Metabolites in Blood Components Define Optimal Blood Processing Conditions [0.03%]
血制品中的犬尿酸代谢物稳定性研究确定了最佳的血液处理条件
Benjamin Heng,Ananda Staats Pires,Sharron Chow et al.
Benjamin Heng et al.
The kynurenine pathway (KP) is the main pathway of tryptophan (TRP) metabolism that generates energy for multiple cellular processes. The activity of this pathway has been shown to be dysregulated in multiple human diseases. The resultant m...
Normative Data on Serum and Plasma Tryptophan and Kynurenine Concentrations from 8089 Individuals Across 120 Studies: A Systematic Review and Meta-Analysis [0.03%]
8089例个体横跨120项研究的血清和血浆色氨酸及犬尿酸浓度的文献系统综述与荟萃分析(normative数据)
Najwa-Joelle Metri,Ali S Butt,Ava Murali et al.
Najwa-Joelle Metri et al.
In this systematic review and meta-analysis, a normative dataset is generated from the published literature on the kynurenine pathway in control participants extracted from case-control and methodological validation studies. Study character...
The Role of the Kynurenine/AhR Pathway in Diseases Related to Metabolism and Cancer [0.03%]
犬尿酸/AhR通路在代谢和癌症相关疾病中的作用
Amir Shadboorestan,Meriem Koual,Julien Dairou et al.
Amir Shadboorestan et al.
The Aryl hydrocarbon receptor (AhR) is a xenobiotic and endobiotic receptor, which regulates many cellular processes from contaminant metabolism to immunomodulation. Consequently, it is also involved in pathophysiological pathways and now r...
Contribution of Circulating Host and Microbial Tryptophan Metabolites Toward Ah Receptor Activation [0.03%]
循环宿主和微生物色氨酸代谢物对芳香烃受体活化的贡献
Ethan W Morgan,Fangcong Dong,Andrew J Annalora et al.
Ethan W Morgan et al.
The aryl hydrocarbon receptor (AHR) is a ligand activated transcription factor that plays an integral role in homeostatic maintenance by regulating cellular functions such as cellular differentiation, metabolism, barrier function, and immun...
Endogenous Tryptophan-Derived Ah Receptor Ligands are Dissociated from CYP1A1/1B1-Dependent Negative-Feedback [0.03%]
内源性色氨酸衍生的Ah受体配体与CYP1A1/1B1依赖性的负反馈调节无关
Fangcong Dong,Andrew J Annalora,Iain A Murray et al.
Fangcong Dong et al.
The aryl hydrocarbon receptor (AHR) exerts major roles in xenobiotic metabolism, and in immune and barrier tissue homeostasis. How AHR activity is regulated by the availability of endogenous ligands is poorly understood. Potent AHR ligands ...
Determination of Picolinic Acid by HPLC Coupled With Postcolumn Photo Irradiation Using Zinc Acetate as a Fluorescent Derivatization Reagent [0.03%]
采用乙酸锌作为衍生化试剂的高效液相色谱-柱后光照射法测定吡啶甲酸
Ken-Ichi Mawatari,Yuika Tanikawa,Makoto Yasuda et al.
Ken-Ichi Mawatari et al.
For the fluorometric determination of picolinic acid in human serum, HPLC-postcolumn UV irradiation using zinc acetate has been developed. Picolinic acid in serum sample was separated on a Capcell Pak C18. The mobile phase consisted of 0.1 ...
Interferon-gamma Mediated Metabolic Pathways in Hospitalized Patients During Acute and Reconvalescent COVID-19 [0.03%]
住院COVID-19患者急性期和恢复期的干扰素γ介导的代谢途径
Mario Gietl,Francesco Burkert,Stefanie Seiwald et al.
Mario Gietl et al.
Background: Fatigue, sleep disturbance, and neurological symptoms during and after COVID-19 are common and might be associated with inflammation-induced changes in tryptophan (Trp) and phenylalanine (Phe) metabolism. ...
Endothelial Indoleamine-2,3-Dioxygenase-1 is not Critically Involved in Regulating Antitumor Immunity in the Central Nervous System [0.03%]
中枢神经系统内皮细胞色氨酸酶IDO不参与抗肿瘤免疫反应
A P Abu Hejleh,K Huck,K Jähne et al.
A P Abu Hejleh et al.
The vascular niche of malignant gliomas is a key compartment that shapes the immunosuppressive brain tumor microenvironment (TME). The blood-brain-barrier (BBB) consisting of specialized endothelial cells (ECs) and perivascular cells forms ...
Modulation of Indoleamine 2,3-Dioxygenase 1 During Inflammatory Bowel Disease Activity in Humans and Mice [0.03%]
人类和小鼠炎症性肠病活动期间调节吲哚胺2,3-双加氧酶1
Elisa Proietti,Renske W M Pauwels,Annemarie C de Vries et al.
Elisa Proietti et al.
Background and aims: Indoleamine 2,3 dioxygenase-1 (IDO1), a key enzyme in tryptophan metabolism, is strongly up-regulated both in human inflammatory bowel disease (IBD) and animal models of colitis, however its role in t...