Effects of Kynurenine Pathway Metabolites on Intracellular NAD Synthesis and Cell Death in Human Primary Astrocytes and Neurons [0.03%]
代谢物对人原代星形胶质细胞和神经元中细胞内NAD合成及细胞死亡的影响
Nady Braidy,Ross Grant,Bruce J Brew et al.
Nady Braidy et al.
The kynurenine pathway (KP) is a major route of L-tryptophan catabolism resulting in the production of the essential pyridine nucleotide nicotinamide adenine dinucleotide, (NAD(+)). Up-regulation of the KP during inflammation leads to the r...
Kazuhiro Nakamura,Hiroyuki Hasegawa
Kazuhiro Nakamura
Serotonin (5-hydroxytryptamine [5-HT]) has been implicated in a variety of physiological and pathological functions. Multiple steps of enzyme reactions enable biosynthesis of 5-HT. The first and rate-limiting step of the reaction is the syn...
Assessment of the Potential Role of Tryptophan as the Precursor of Serotonin and Melatonin for the Aged Sleep-wake Cycle and Immune Function: Streptopelia Risoria as a Model [0.03%]
色氨酸作为五羟色胺和褪黑素的前体物质对年老生物体内昼夜节律及免疫功能潜在作用的评估：斑胸草雀模式动物研究
Sergio D Paredes,Carmen Barriga,Russel J Reiter et al.
Sergio D Paredes et al.
In the present review we summarize the relationship between the amino acid, tryptophan, the neurotransmitter, serotonin, and the indole, melatonin, with the rhythms of sleep/wake and the immune response along with the possible connections b...
Paolo guidetti [0.03%]
保罗·吉迪蒂
Robert Schwarcz
Robert Schwarcz
Yiquan Chen,Gilles J Guillemin
Yiquan Chen
Tryptophan is an essential amino acid that can be metabolised through different pathways, a major route being the kynurenine pathway. The first enzyme of the pathway, indoleamine-2,3-dioxygenase, is strongly stimulated by inflammatory molec...
Eduard Maron,Jakov Shlik,David J Nutt
Eduard Maron
A considerable body of evidence suggests the involvement of serotonin neurotransmission in the pathogenesis of panic disorder. Research on pathways and functions of tryptophan, an essential amino acid converted into serotonin, may advance o...
Introductory editorial [0.03%]
简讯：卷首语
Gilles J Guillemin
Gilles J Guillemin
Specificity of the Acute Tryptophan and Tyrosine Plus Phenylalanine Depletion and Loading Tests Part II: Normalisation of the Tryptophan and the Tyrosine Plus Phenylalanine to Competing Amino Acid Ratios in a New Control Formulation [0.03%]
特异性急性色氨酸和酪氨苯氨酰剥夺及补充试验 第二部分：用新的对照配方将色氨酸和酪氨苯氨酰与竞争性氨基酸比率进行标准化
Abdulla A-B Badawy,Donald M Dougherty,Dawn M Richard
Abdulla A-B Badawy
Current formulations for acute tryptophan (Trp) or tyrosine (Tyr) plus phenylalanine (Phe) depletion and loading cause undesirable decreases in ratios of Trp or Tyr + Phe to competing amino acids (CAA), thus undermining the specificities of...
Specificity of the acute tryptophan and tyrosine plus phenylalanine depletion and loading tests I. Review of biochemical aspects and poor specificity of current amino Acid formulations [0.03%]
特异性急性色氨酸和酪氨酸、苯丙氨酸贫化及补充试验Ⅰ.生化方面现状回顾以及现有氨基酸配制的非特异性
Abdulla A-B Badawy,Donald M Dougherty,Dawn M Richard
Abdulla A-B Badawy
The acute tryptophan or tyrosine plus phenylalanine depletion and loading tests are powerful tools for studying the roles of serotonin, dopamine and noradrenaline in normal subjects and those with behavioural disorders. The current amino ac...
L-Tryptophan: Basic Metabolic Functions, Behavioral Research and Therapeutic Indications [0.03%]
L-色氨酸：基本代谢功能、行为研究和治疗作用
Dawn M Richard,Michael A Dawes,Charles W Mathias et al.
Dawn M Richard et al.
An essential component of the human diet, L-tryptophan is critical in a number of metabolic functions and has been widely used in numerous research and clinical trials. This review provides a brief overview of the role of L-tryptophan in pr...