The Effect of L-Tryptophan Intake on Dynamic Strength in Paralympic Powerlifting [0.03%]
L-色氨酸摄入对残奥力量举运动员动态峰值肌力的影响
Márcio Getirana-Mota,Felipe J Aidar,Raphael Fabricio de Souza et al.
Márcio Getirana-Mota et al.
Introduction: L-tryptophan supplementation has been studied in endurance sports with controversial results, and its influence on maximal strength sports remains largely unexplored. This study investigated whether L-trypto...
An Ecofriendly L-Tryptophan Containing UVA-1 Permissive Sunscreen Formulation: A Novel Approach for Inflammatory and Fibrosing Skin Diseases [0.03%]
一种新型环保L-色氨酸含UVA-1允许型防晒配方：炎症和纤维化皮肤病的治疗新思路
Rowland Noakes
Rowland Noakes
UVA-1 phototherapy, used in the management of psoriasis, atopic dermatitis and fibrosing skin disorders has been reported to mediate part of its therapeutic benefit via aryl hydrocarbon receptor (AHR) signalling. Accessibility to therapy re...
Altered Tryptophan-Kynurenine Pathway and Low-Grade Inflammation in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Insights from LC-MS/MS-Based Metabolite Profiling [0.03%]
基于LC-MS/MS的代谢物谱分析在代谢功能障碍相关脂肪性肝病(MASLD)中观察到的色氨酸-犬尿酸途径改变和低度炎症：新视野
Kübranur Ünal,Leyla İbrahimkhanlı,Mehmet Emre Erol et al.
Kübranur Ünal et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multisystem disorder characterized by hepatic lipid accumulation, low-grade inflammation, and metabolic dysregulation. Although the kynurenine pathway has been implicated...
Accumulation of Quinolinic Acid Modulates the Pulmonary Immune Response During Influenza Infection [0.03%]
喹啉酸的积累可调节流感感染过程中的肺部免疫反应
Guillaume Pamart,Benjamin Hennart,Anaïs Ollivier et al.
Guillaume Pamart et al.
Influenza viruses cause a highly contagious, acute pulmonary disease that results in significant mortality each year. These infections trigger the production of interferons, known to induce the expression of the rate-limiting enzyme in the ...
Glucocorticoid Treatment Dampens Kynurenine Pathway Activation and Cytokine Release in Immune Stimulated Human Microglia [0.03%]
糖皮质激素治疗可抑制人类小胶质细胞中促炎刺激诱导的犬尿氨酸代谢通路激活及细胞因子释放
Martina Esposito Soccoio,Robert P Mason,Julien Devilliers et al.
Martina Esposito Soccoio et al.
As a first line of defence for the central nervous system (CNS), microglia play a critical role in maintaining homeostasis within the brain. Upon detection of damage or threats, activated cells release factors to communicate and potentiate ...
Kynurenine Pathway Dysregulation in Parkinson's Disease: Insights for Disease Modulation and Therapy [0.03%]
帕金森病中的犬尿酸途径失调：对疾病调控和治疗的启示
Vaibhav A Chakkarwar,Yogesh A Kulkarni
Vaibhav A Chakkarwar
Parkinson's disease (PD) is identified as the most common neurodegenerative disorder of the central nervous system. Around 8.5 million individuals suffer from PD globally. Neuroinflammation triggers the activation of microglia, resulting in...
Development of a Novel Method to Quantify Quinolinic Acid in Biological Samples [0.03%]
一种定量生物样本中喹啉酸的新方法的开发研究论文
Masatsuna Tasaka,Hidetsugu Fujigaki,Sayaka Sugiura et al.
Masatsuna Tasaka et al.
Background: The accumulation of quinolinic acid (QUIN) in cerebrospinal fluid and serum may be used as a biomarker for various neuropsychiatric and inflammatory diseases. In this study, we developed a highly sensitive met...
Neuroactive Kynurenine Metabolite Alterations Unveil Novel Association to Locomotor Deterioration in Diabetic Neuropathy [0.03%]
神经活性犬尿素代谢物的改变揭露了糖尿病周围神经病变与运动功能损伤的新关联
Alejandra Perez-Alvarez,Victor Salazar,Gustavo Bruges et al.
Alejandra Perez-Alvarez et al.
Background: The effect of prolonged hyperglycemia on the sensory pathway of the nervous system has been the focus of numerous diabetes studies that aim at understanding the pathophysiology of the underlying inflammatory c...
Molecular Insights Into the Interaction of Tryptophan Metabolites With Tryptophan and Indoleamine 2,3-Dioxygenases: Nitric Oxide a New Effector of Tryptophan 2,3-Dioxygenase and Their Roles in Infection [0.03%]
色氨酸代谢产物与色氨酸和吲哚胺2，3-双氧酶相互作用的分子见解：一氧化氮是一种新的色氨酸2,3-过氧化物抑制剂及其在感染中的作用
Abdulla A-B Badawy,Shazia Dawood
Abdulla A-B Badawy
Feedback and other negative controls are important determinants of metabolic pathway activities. Other than inhibition of indoleamine 2,3-dioxygenase (IDO) by tryptophan (Trp) and nitric oxide (NO) and feedback inhibition of Trp 2,3-dioxyge...
Activation of the IDO1-GCN2-ATF4-CHOP Pathway During the Massive Generation of Antibody-Secreting Cells in Dengue Patients Through Single-Cell Transcriptomics [0.03%]
单细胞转录组学揭示登革热患者通过大量生成抗体分泌细胞激活IDO1-GCN2-ATF4-CHOP通路
Jéssica C Nascimento,André N A Gonçalves,Karen T Akashi et al.
Jéssica C Nascimento et al.
Dengue, a widespread mosquito-borne disease, annually afflicts millions globally, posing substantial mortality risks. Preceding disease defervescence, a marked and transient surge in antibody-secreting cell (ASC) frequency correlates with d...