Effects of acute tryptophan depletion on three different types of behavioral impulsivity [0.03%]
急性色氨酸耗竭对三种行为冲动的影响
Donald M Dougherty,Dawn M Richard,Lisa M James et al.
Donald M Dougherty et al.
Introduction: While central nervous system serotonin has been implicated in a variety of problematic impulsive behaviors, biological manipulation of brain serotonin using acute tryptophan depletion for studying changes in...
Proteasomal Degradation of Indoleamine 2,3-Dioxygenase in CD8 Dendritic Cells is Mediated by Suppressor of Cytokine Signaling 3 (SOCS3) [0.03%]
抑制细胞因子信号传导分子SOCS3介导CD8树突状细胞中色氨酸酶IDO的蛋白酶体降解途径
Maria T Pallotta,Ciriana Orabona,Claudia Volpi et al.
Maria T Pallotta et al.
Indoleamine 2,3-dioxygenase (IDO) catalyzes the initial and rate-limiting step of tryptophan catabolism in a specific pathway, resulting in a series of extracellular messengers collectively known as kynurenines. IDO has been recognized as a...
Indoleamine 2,3-dioxygenase in human hematopoietic stem cell transplantation [0.03%]
人造血干细胞移植中的吲哚胺2，3-双加氧酶
Birgit Jürgens,Julia Raberger,Dietmar Fuchs et al.
Birgit Jürgens et al.
In recent years tryptophan metabolism and its rate limiting enzyme indoleamine 2,3-dioxygenase (IDO) have attracted increasing attention for their potential to modulate immune responses including the regulation of transplantation tolerance....
Serum levels of tryptophan, 5-hydroxytryptophan and serotonin in patients affected with different forms of amenorrhea [0.03%]
不同形式闭经患者的血清色氨酸、5-羟色氨酸和血清素水平
S Comai,A Bertazzo,N Carretti et al.
S Comai et al.
Tryptophan (Trp) is present in the serum, partly bound to albumine and in the free form. The unbound portion of circulating tryptophan has the property of crossing the hematoencephalic barrier and being converted within the brain into serot...
Accelerated tryptophan degradation predicts poor survival in trauma and sepsis patients [0.03%]
色氨酸分解代谢预测创伤及感染患者的不良预后
Martin Ploder,Andreas Spittler,Katharina Kurz et al.
Martin Ploder et al.
Immune system activation and inflammation accompanies immune dysfunction in trauma and sepsis patients. Immunodeficiency may develop in such patients as one consequence of an activated chronic pro-inflammatory response. According to recent ...
On the Biological Importance of the 3-hydroxyanthranilic Acid: Anthranilic Acid Ratio [0.03%]
关于3-羟基芥酸与芥酸比率的生物学重要性
L Gail Darlington,Caroline M Forrest,Gillian M Mackay et al.
L Gail Darlington et al.
Of the major components of the kynurenine pathway for the oxidative metabolism of tryptophan, most attention has focussed on the N-methyl-D-aspartate (NMDA) receptor agonist quinolinic acid, and the glutamate receptor blocker kynurenic acid...
Gilles J Guillemin
Gilles J Guillemin
Endogenous Kynurenine Aminotransferases Inhibitor is Proposed to Act as "Glia Depressing Factor" (GDF) [0.03%]
内源性犬尿氨酸氨基转移酶抑制剂可作为“胶质细胞抑制因子”（GDF）发挥作用
Halina Baran,Berthold Kepplinger,Markus Draxler
Halina Baran
The endogenous neuroinhibitory amino acid receptor antagonist kynurenic acid (KYNA) has been hypothetically linked to physiological processes and to the pathogenesis of several brain disorders. The aim of this study was to search KYNA metab...
Role of the NMDA-receptor in Prepulse Inhibition in the Rat [0.03%]
N-甲基-D天冬氨酸受体在大鼠 prepulse 抑制中的作用研究
Klas Linderholm,Susan Powell,Elin Olsson et al.
Klas Linderholm et al.
Kynurenic acid (KYNA) is an endogenous metabolite of tryptophan. Studies have revealed increased brain KYNA levels in patients with schizophrenia. Prepulse inhibition (PPI) is a behavioral model for sensorimotor gating and found to be reduc...
R S Grant,S E Coggan,G A Smythe
R S Grant
Picolinic Acid is an endogenous metabolite of L-tryptophan (TRP) that has been reported to possess a wide range of neuroprotective, immunological, and anti-proliferative affects within the body. However the salient physiological function of...