L-Tryptophan Production by Auxotrophic and Analogue Resistant Mutants of Aureobacterium flavescens [0.03%]
色氨酸营养缺陷型及类似物抗性突变菌株产L-色氨酸研究
A Roy,S K Mukhopadhyay
A Roy
A number of tyrosine plus phenylalanine double auxotrophic mutants were isolated by N-methyl-N-nitro-N-nitrosoguanidine (MNNG) treatment of a locally isolated strain of Aureobacterium flavescens of which 11A(39) and 11A(17) were selected on...
Effects of Kynurenine Pathway Inhibition on NAD Metabolism and Cell Viability in Human Primary Astrocytes and Neurons [0.03%]
喹啉酸途径抑制对人原代星形胶质细胞和神经元中烟酰胺腺嘌呤二核苷酸代谢和细胞活力的影响
Nady Braidy,Gilles J Guillemin,Ross Grant
Nady Braidy
The kynurenine pathway (KP) is the principle route of L-Tryptophan (TRP) metabolism, producing several neurotoxic and neuroprotective metabolic precursors before complete oxidation to the essential pyridine nucleotide nicotinamide adenine d...
Tryptophan transport in human fibroblast cells-a functional characterization [0.03%]
人成纤维细胞中色氨酸的转运作用及功能特征分析
Ravi Vumma,Jessica Johansson,Tommy Lewander et al.
Ravi Vumma et al.
There are indications that serotonergic neurotransmission is disturbed in several psychiatric disorders. One explanation may be disturbed transport of tryptophan (precursor for serotonin synthesis) across cell membranes. Human fibroblast ce...
Tryptophan oxidative metabolism catalyzed by geobacillus stearothermophilus: a thermophile isolated from kuwait soil contaminated with petroleum hydrocarbons [0.03%]
来源于石油污染的 Kuwait 土壤分离到的耐热菌地芽孢杆菌催化的色氨酸代谢路径研究
Jassim M Al-Hassan,Samira Al-Awadi,Sosamma Oommen et al.
Jassim M Al-Hassan et al.
Tryptophan metabolism has been extensively studied in humans as well as in soil. Its metabolism takes place mainly through kynurenine pathway yielding hydroxylated, deaminated and many other products of physiological significance. However, ...
Rapid Isocratic Liquid Chromatographic Separation and Quantification of Tryptophan and Six kynurenine Metabolites in Biological Samples with Ultraviolet and Fluorimetric Detection [0.03%]
采用紫外及荧光检测的高效等度液相色谱法对生物样本中的色氨酸和六种犬尿酸代谢产物进行分离与定量
Abdulla A-B Badawy,Christopher J Morgan
Abdulla A-B Badawy
A simple, rapid isocratic liquid chromatographic procedure with ultraviolet and fluorimetric detection is described for the separation and quantification of L-tryptophan (Trp) and six of its kynurenine metabolites (kynurenine, 3-hydroxykynu...
Alzheimer's and seizures: interleukin-18, indoleamine 2,3-dioxygenase and quinolinic Acid [0.03%]
阿茨海默病与癫痫发作：细胞因子白介素-18、吲哚胺2，3双氧酶及四氢喹啉酸的关系
G Anderson,Jo Ojala
G Anderson
Emergent seizures are common in Alzheimer's disease (AD), although the mechanisms mediating this are unknown. It is proposed that stress induced interleukin-18 (IL-18), via interferon-gamma (IFNy) and independently, increases indoleamine 2,...
Understanding the roles of the kynurenine pathway in multiple sclerosis progression [0.03%]
色氨酸犬尿素途径在多发性硬化症进程中的作用机制研究
Chai K Lim,Bruce J Brew,Gayathri Sundaram et al.
Chai K Lim et al.
The kynurenine pathway (KP) is a major degradative pathway of tryptophan ultimately leading to the production of nicotinamide adenine dinucleotide (NAD(+)) and is also one of the major regulatory mechanisms of the immune response. The KP is...
Kynurenine Pathway Metabolism is Involved in the Maintenance of the Intracellular NAD Concentration in Human Primary Astrocytes [0.03%]
苦那リン酸代謝はヒト原代星形細胞における細胞内NAD濃度維持に関与する
Ross Grant,Susan Nguyen,Gilles Guillemin
Ross Grant
Efficient synthesis of NAD(+) is critical to maintaining cell viability in all organs of the body. However, little is known of the pathway(s) by which cells of the central nervous system produce NAD(+). The aim of this study was to investig...
Tryptophan, Neurodegeneration and HIV-Associated Neurocognitive Disorder [0.03%]
色氨酸、神经退行性变和HIV相关神经认知障碍
Nicholas W S Davies,Gilles Guillemin,Bruce J Brew
Nicholas W S Davies
This review presents an up-to-date assessment of the role of the tryptophan metabolic and catabolic pathways in neurodegenerative disease and HIV-associated neurocognitive disorder. The kynurenine pathway and the effects of each of its enzy...
IDO-Mediated Tryptophan Degradation in the Pathogenesis of Malignant Tumor Disease [0.03%]
恶性肿瘤疾病发生发展中的IDO色氨酸代谢通路及其调控机制研究进展
Robert Sucher,Katharina Kurz,Guenter Weiss et al.
Robert Sucher et al.
Immune escape is a fundamental trait of cancer in which the Th1-type cytokine interferon- γ (IFN-γ) seems to play a key role. Among other tumoricidal biochemical pathways, IFN-γ induces the tryptophan-degrading enzyme indoleamine 2,3-dio...