Characterization of the kynurenine pathway and quinolinic Acid production in macaque macrophages [0.03%]
猕猴巨噬细胞中犬尿氨酸途径和喹啉酸产生的特性研究
Chai K Lim,Margaret M C Yap,Stephen J Kent et al.
Chai K Lim et al.
The kynurenine pathway (KP) and one of its end-products, the excitotoxin quinolinic acid (QUIN), are involved in the pathogenesis of several major neuroinflammatory brain diseases. A relevant animal model to study KP metabolism is now neede...
Transport of Kynurenic Acid by Rat Organic Anion Transporters rOAT1 and rOAT3: Species Difference between Human and Rat in OAT1 [0.03%]
大鼠有机阴离子转运蛋白rOAT1和rOAT3对犬尿酸的转运及人与大鼠OAT1物种差异的研究
Yuichi Uwai,Hiroaki Hara,Kikuo Iwamoto
Yuichi Uwai
A tryptophan catabolite, kynurenic acid, is involved in schizophrenia and uremia; there is little information on the mechanism of its disposition. Recently, our laboratory showed that kynurenic acid is a good substrate of human organic anio...
Kynurenic Acid Metabolism in Various Types of Brain Pathology in HIV-1 Infected Patients [0.03%]
HIV-1感染者各种脑病变中的犬尿氨酸代谢酸代谢
H Baran,J A Hainfellner,B Kepplinger
H Baran
Kynurenic acid, an intermediate metabolite of L-kynurenine, is a competitive antagonist of inotropic excitatory amino acid (EAA) receptors as well as a non competitive antagonist of 7 alpha nicotine cholinergic receptors and its involvement...
Chiaki Hiratsuka,Tsutomu Fukuwatari,Katsumi Shibata
Chiaki Hiratsuka
The purpose of this study was to determine, using the high-performance liquid chromatographic methods recently modified by us, the fate of dietary tryptophan in 17 healthy female Japanese adults who ate self-selected food. The experimental ...
A Brief Historic Overview of Clinical Disorders Associated with Tryptophan: The Relevance to Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM) [0.03%]
与色氨酸相关的临床障碍的历史回顾及其对慢性疲劳综合征(CFS)和纤维肌痛(FM)的启示
Adele Blankfield
Adele Blankfield
Last century there was a short burst of interest in the tryptophan related disorders of pellagra and related abnormalities that are usually presented in infancy.1,2 Nutritional physiologists recognized that a severe human dietary deficiency...
Kynurenine Pathway in Skin Cells: Implications for UV-Induced Skin Damage [0.03%]
皮肤细胞中的犬尿酸途径：紫外线引起的皮肤损伤的机制及其潜在治疗靶点
Diba Sheipouri,Nady Braidy,Gilles J Guillemin
Diba Sheipouri
The kynurenine pathway (KP) is the principle route of catabolism of the essential amino acid tryptophan, leading to the production of several neuroactive and immunoregulatory metabolites. Alterations in the KP have been implicated in variou...
María Garrido,Javier Espino,Antonio F Toribio-Delgado et al.
María Garrido et al.
L-Tryptophan (tryptophan) is an essential amino acid in humans. It has important roles as a precursor of different bioactive compounds. Based on previous studies in which tryptophan has been shown to be present in fresh cherries, the aim of...
Quinolinic Acid, an endogenous molecule combining excitotoxicity, oxidative stress and other toxic mechanisms [0.03%]
内源性兴奋毒性、氧化应激及其他毒性的结合分子喹啉酸
Verónica Pérez-De La Cruz,Paul Carrillo-Mora,Abel Santamaría
Verónica Pérez-De La Cruz
Quinolinic acid (QUIN), an endogenous metabolite of the kynurenine pathway, is involved in several neurological disorders, including Huntington's disease, Alzheimer's disease, schizophrenia, HIV associated dementia (HAD) etc. QUIN toxicity ...
Stochastic resonance activity influences serum tryptophan metabolism in healthy human subjects [0.03%]
随机共振活动影响健康人体血清色氨酸代谢
Berthold Kepplinger,Halina Baran,Brenda Sedlnitzky-Semler et al.
Berthold Kepplinger et al.
Background: Stochastic resonance therapy (SRT) is used for rehabilitation of patients with various neuropsychiatric diseases. An alteration in tryptophan metabolism along the kynurenine pathway has been identified in the ...
Kynurenine pathway Hypothesis: The nature of the chronic Fatigue syndrome (cFs) Revisited [0.03%]
犬尿酸途径假说：慢性疲劳综合征的再探讨
Adele Blankfield
Adele Blankfield