The Tumor-Selective Cytotoxic Agent β-Lapachone is a Potent Inhibitor of IDO1 [0.03%]
β-lapachone(IDO1的抑制剂)是一种肿瘤选择性细胞毒制剂
Hollie E Flick,Judith M Lalonde,William P Malachowski et al.
Hollie E Flick et al.
β-lapachone is a naturally occurring 1,2-naphthoquinone-based compound that has been advanced into clinical trials based on its tumor-selective cytotoxic properties. Previously, we focused on the related 1,4-naphthoquinone pharmacophore as...
L-tryptophan metabolism in pregnant mice fed a high L-tryptophan diet and the effect on maternal, placental, and fetal growth [0.03%]
妊娠小鼠喂食高L-色氨酸饮食后的L-色氨酸代谢及对母体、胎盘和胎儿生长的影响
Ai Tsuji,Chifumi Nakata,Mitsue Sano et al.
Ai Tsuji et al.
Excess L-tryptophan (L-Trp) in the diet decreases fetal body weight. However, the relationship between L-Trp concentration and its effects on maternal, placental, and fetal growth are not well-understood. We investigated the effects of exce...
Exploitation of the IDO Pathway in the Therapy of Rheumatoid Arthritis [0.03%]
IDO通路在类风湿性关节炎治疗中的作用机制研究
Richard O Williams
Richard O Williams
Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting step along the kynurenine pathway and is thought to play a key role in immune homeostasis through depletion of tryptophan and accumulation of kynurenines. In this review we su...
Tryptophan-restriction diets help to maintain L-tryptophan homeostasis in tryptophan 2,3-dioxygenase knockout mice [0.03%]
色氨酸限制性饮食有助于三重氨酚2,3- dioxygenase基因敲除小鼠维持L-色氨酸稳态
Akihiro Maeta,Tsutomu Fukuwatari,Hiroshi Funakoshi et al.
Akihiro Maeta et al.
We hypothesized that the requirements of essential nutrients are dependent upon catabolic abilities. Mice lacking L-tryptophan 2,3-dioxygenase (TDO) are available. The body concentration of L-tryptophan (L-Trp) has been reported to be highe...
Yuki Murakami,Kuniaki Saito
Yuki Murakami
L-Tryptophan (L-TRP) is a nutritionally essential amino acid and the kynurenine (KYN) pathway is the major route of L-TRP catabolism. Besides being synthesized for proteins, L-TRP and its metabolites have critical roles for the functions of...
Kynurenine Pathway Pathologies: do Nicotinamide and Other Pathway Co-Factors have a Therapeutic Role in Reduction of Symptom Severity, Including Chronic Fatigue Syndrome (CFS) and Fibromyalgia (FM) [0.03%]
犬尿酸途径病理：烟酰胺及其他途径辅因子是否在降低症状严重程度方面具有治疗作用，包括慢性疲劳综合征(CFS)和纤维肌痛症(FM)
Adele Blankfield
Adele Blankfield
The definition of dual tryptophan pathways has increased the understanding of the mind-body, body-mind dichotomy. The serotonergic pathway highlights the primary (endogenous) psychiatric disorders. The up-regulation of the kynurenine pathwa...
Role of NAD(+), Oxidative Stress, and Tryptophan Metabolism in Autism Spectrum Disorders [0.03%]
自闭症谱系障碍中烟酰胺腺嘌呤二核苷酸、氧化应激和色氨酸代谢的作用
Musthafa Mohamed Essa,Selvaraju Subash,Nady Braidy et al.
Musthafa Mohamed Essa et al.
Autism spectrum disorder (ASD) is a pervasive neuro-developmental disorder characterized by impaired social interaction, reduced/absent verbal and non-verbal communication, and repetitive behavior during early childhood. The etiology of thi...
Determination of l-tryptophan and l-kynurenine in Human Serum by using LC-MS after Derivatization with (R)-DBD-PyNCS [0.03%]
(R)-DBD-PyNCS衍生化结合LC-MS法测定人血清中L-色氨酸和L-犬尿酸水平
Hayato Ohashi,Hideaki Iizuka,Shunsuke Yoshihara et al.
Hayato Ohashi et al.
Concentrations of l-tryptophan (l-Trp) and its metabolite, l-kynurenine (l-KYN), in sera of 19 normal subjects (age: 23.6 ± 3.5 y, male: 8, female: 11) were determined by high-performance liquid chromatography with mass-spectrometric detec...
Tsutomu Fukuwatari,Katsumi Shibata
Tsutomu Fukuwatari
Mammals, including humans, can synthesize the vitamin nicotinamide from tryptophan in the liver. The resultant nicotinamide is distributed to non-hepatic tissues. We have studied the effects of changes in tryptophan-nicotinamide metabolism ...
Gilles J Guillemin
Gilles J Guillemin