Magdalena E Kegel,Maria Bhat,Elisabeth Skogh et al.
Magdalena E Kegel et al.
Several studies suggest a role for kynurenic acid (KYNA) in the pathophysiology of schizophrenia. It has been proposed that increased brain KYNA levels in schizophrenia result from a pathological shift in the kynurenine pathway toward enhan...
Tryptophan and kynurenic Acid may produce an amplified effect in central fatigue induced by chronic sleep disorder [0.03%]
色氨酸和羌尿酸可能放大慢性睡眠障碍引起的中枢疲劳效应
Masatoshi Yamashita,Takanobu Yamamoto
Masatoshi Yamashita
Tryptophan (TRP) and its neuroactive metabolite, kynurenic acid (KYNA), are thought to play key roles in central fatigue, but the specifics are still unknown. To clarify their roles in the brain, we developed a rat model of central fatigue ...
Kynurenic Acid levels in cerebrospinal fluid from patients with Alzheimer's disease or dementia with lewy bodies [0.03%]
阿尔茨海默病或路易体痴呆患者脑脊液中奎奴尔酸水平的变化
Malin Wennström,Henrietta M Nielsen,Funda Orhan et al.
Malin Wennström et al.
Kynurenic acid (KYNA) is implicated in cognitive functions. Altered concentrations of the compound are found in serum and cerebrospinal fluid (CSF) of patients with Alzheimer's disease (AD). Further studies to determine whether KYNA serves ...
Rowland Noakes,Nick Mellick
Rowland Noakes
Cutaneous sclerosis, resembling that seen in subcutaneous morphea, is a feature of eosinophilic fasciitis and eosinophilia-myalgia syndrome, two conditions in which the kynurenine pathway is known to be activated. To investigate the possibi...
Sustained elevation of kynurenic Acid in the cerebrospinal fluid of patients with herpes simplex virus type 1 encephalitis [0.03%]
单纯疱疹病毒1型脑炎患者脑脊液中犬尿酸水平持续升高
Ann Atlas,Elisabeth Franzen-Röhl,Johan Söderlund et al.
Ann Atlas et al.
Herpes simplex virus (HSV) type 1 encephalitis (HSE) is a viral infectious disease with commonly occurring neurodegeneration and neurological/cognitive long-term sequelae. Kynurenic acid (KYNA) is a neuroactive tryptophan metabolite, which ...
Big brains, meat, tuberculosis, and the nicotinamide switches: co-evolutionary relationships with modern repercussions? [0.03%]
大腦、肉類、結核病和煙酸開關：共生演化關係及其現代後果？
Adrian C Williams,Robin I M Dunbar
Adrian C Williams
Meat-eating was a game changer for human evolution. We suggest that the limiting factors for expanding brains earlier were scarcities of nicotinamide and tryptophan. In humans and some other omnivores, lack of meat causes these deficiencies...
Relationships between Salivary Melatonin Levels, Quality of Sleep, and Stress in Young Japanese Females [0.03%]
年轻日本女性唾液褪黑激素水平、睡眠质量和压力之间的关系
Yasuhiro Ito,Tadayuki Iida,Yuumi Yamamura et al.
Yasuhiro Ito et al.
A decrease in the quality of sleep is believed to cause anxiety and worsen depression. Comparisons of salivary melatonin levels with different factors including quality of sleep, state and trait anxieties, and depression, were conducted to ...
Effects of tranilast on the urinary excretion of kynurenic and quinolinic Acid under conditions of L tryptophan loading [0.03%]
tranilast对L-色氨酸负荷下尿苦马豆酸和赤霉酸排泄的影响
Rowland R Noakes
Rowland R Noakes
The pathogenesis of morphea and other cutaneous sclerosing disorders remain poorly understood. Although they are considered to be autoimmune disorders, abnormal tryptophan metabolism may be involved. Current therapy is directed to supressin...
Simon P Jones,Gilles J Guillemin,Bruce J Brew
Simon P Jones
The kynurenine pathway (KP) is the main catabolic pathway of the essential amino acid tryptophan. The KP has been identified to play a critical role in regulating immune responses in a variety of experimental settings. It is also known to b...
Michal P Turski,Monika Turska,Piotr Paluszkiewicz et al.
Michal P Turski et al.
This review provides information on the most recent findings concerning presence, origin, and role of kynurenic acid (KYNA), a tryptophan metabolite, in the digestive system. KYNA is an antagonist of both the ionotropic glutamate receptors ...