Organ Correlation with Tryptophan Metabolism Obtained by Analyses of TDO-KO and QPRT-KO Mice [0.03%]
通过分析TDO-KO和QPRT-KO小鼠获得的器官色氨酸代谢关联性研究
Katsumi Shibata,Tsutomu Fukuwatari
Katsumi Shibata
The aim of this article is to report the organ-specific correlation with tryptophan (Trp) metabolism obtained by analyses of tryptophan 2,3-dioxygenase knockout (TDO-KO) and quinolinic acid phosphoribosyltransferase knockout (QPRT-KO) mice ...
Induction of TDO2 and IDO2 in Liver by High-Fat Feeding in Mice: Discrepancies with Human Obesity [0.03%]
小鼠由高脂肪诱导的肝脏TDO2和IDO2与人类肥胖不符
Odile Poulain-Godefroy,Elodie Eury,Audrey Leloire et al.
Odile Poulain-Godefroy et al.
Low-grade and chronic inflammation is elicited in white adipose tissue in human obesity. The presence of inflammatory molecules leads to an increased tryptophan catabolism through the induction of indoleamine-2,3-dioxygenase-1 (IDO1). In or...
Chronic Antipsychotic Treatment in the Rat - Effects on Brain Interleukin-8 and Kynurenic Acid [0.03%]
慢性抗精神病药物治疗对大鼠脑白细胞介素-8和犬尿酸的影响
Markus K Larsson,Lilly Schwieler,Michel Goiny et al.
Markus K Larsson et al.
Schizophrenia is associated with activation of the brain immune system as reflected by increased brain levels of kynurenic acid (KYNA) and proinflammatory cytokines. Although antipsychotic drugs have been used for decades in the treatment o...
Tryptophan Catabolism in Chronic Viral Infections: Handling Uninvited Guests [0.03%]
慢性病毒感染中的色氨酸降解：应对不速之客
Vikram Mehraj,Jean-Pierre Routy
Vikram Mehraj
l-Tryptophan (l-Trp) is an essential amino acid that possesses diverse metabolic, neurological, and immunological roles spanning from the synthesis of proteins, neurotransmitter serotonin, and neurohormone melatonin, to its degradation into...
Method for Evaluation of the Requirements of B-group Vitamins Using Tryptophan Metabolites in Human Urine [0.03%]
使用人尿中色氨酸代谢物评估B族维生素需求的方法
Katsumi Shibata,Junko Hirose,Tsutomu Fukuwatari
Katsumi Shibata
Tryptophan metabolism is directly involved with B-group vitamins such as vitamin B2, niacin, and vitamin B6, and indirectly with vitamin B1 and pantothenic acid. We evaluated the validity of requirements of B-group vitamins set by the Dieta...
Tryptophan-ethylester, the false (unveiled) melatonin isomer in red wine [0.03%]
色氨酸乙酯：葡萄酒中的假（未揭开的）褪黑素异构体
Marcello Iriti,Ileana Vigentini
Marcello Iriti
Among the food plants, the presence of melatonin in grapes (Vitis vinifera L.) deserves particular attention because of the production of wine, an alcoholic beverage of economic relevance and with putative healthy effects. Furthermore, mela...
Conversion Percentage of Tryptophan to Nicotinamide is Higher in Rice Protein Diet than in Wheat Protein Diet in Rats [0.03%]
与小麦蛋白质相比，稻米蛋白质膳食中色氨酸向烟酸转化百分比更高
Katsumi Shibata,Tsutomu Fukuwatari,Tomoyo Kawamura
Katsumi Shibata
We reported previously that the pellagragenic property of corn protein is not only low l-tryptophan concentration but also the lower conversion percentage of l-tryptophan to nicotinamide; the amino acid composition greatly affected the conv...
The aryl hydrocarbon receptor: a review of its role in the physiology and pathology of the integument and its relationship to the tryptophan metabolism [0.03%]
芳烃受体：其在皮肤生理和病理学中的作用及其与色氨酸代谢的关系综述
Rowland Noakes
Rowland Noakes
The aryl hydrocarbon receptor (AHR) is a cytosolic receptor for low molecular weight molecules, of which the most widely recognized ligand is 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), and the most widely recognized effect, chloracne. Adve...
Enantiomeric Separation of Monosubstituted Tryptophan Derivatives and Metabolites by HPLC with a Cinchona Alkaloid-Based Zwitterionic Chiral Stationary Phase and Its Application to the Evaluation of the Optical Purity of Synthesized 6-Chloro-l-Tryptophan [0.03%]
手性的氯代色氨酸光学纯度的评价及其代谢物对映异构体的拆分
Takeshi Fukushima,Anna Sugiura,Ippei Furuta et al.
Takeshi Fukushima et al.
6-Chlorotryptophan possesses unique bioactivity and can be used as a precursor for several bioactive compounds in medicinal chemistry. It was enantioselectively synthesized by condensing 6-chloroindole with racemic N-acetylserine, followed ...
Mechanisms of the pellagragenic effect of leucine: stimulation of hepatic tryptophan oxidation by administration of branched-chain amino acids to healthy human volunteers and the role of plasma free tryptophan and total kynurenines [0.03%]
亮氨酸pellagragenic作用机制：分支氨基酸对健康志愿者肝色氨酸氧化的刺激和血浆游离色氨酸及总犬尿酸的作用
Abdulla A-B Badawy,Sarah L Lake,Donald M Dougherty
Abdulla A-B Badawy
The pellagragenic effect of leucine (Leu) has been proposed to involve modulation of L-tryptophan (Trp) metabolism along the hepatic kynurenine pathway. Here, we discuss some of the mechanisms suggested and report the effects in healthy vol...