Potential Treatment for ADHD Based on Recovery from Tryptophan-Induced Central Fatigue by Powerful Competitive Inhibition of L-System Amino Acid Transporter [0.03%]
基于色氨酸诱导的中枢疲劳恢复治疗ADHD：强有力的L-系统氨基酸转运的竞争性抑制作用
Takanobu Yamamoto,Bianca Koleda-Yamamoto
Takanobu Yamamoto
Fatigability in attention deficit hyperactivity disorder (ADHD) is associated with the characteristic inattention behavior. Evidence has indicated that the administration of branched-chain amino acids (BCAAs) to Nagase analbuminemic rats (N...
Benoît Gendrot,Cathy Vaillancourt,Guillemette Fouquet
Benoît Gendrot
Tryptophan is an essential amino acid required for protein synthesis and a precursor of key bioactive metabolites produced through the kynurenine, indole and serotonin pathways. Beyond its nutritional role, tryptophan metabolism critically ...
Corrigendum to "Development of a Novel Method to Quantify Quinolinic Acid in Biological Samples" [0.03%]
关于“一种新的测定生物样本中夸西萘酸含量的方法的开发”的勘误通知
[This corrects the article DOI: 10.1177/11786469251390415.]. © The Author(s) 2026.
Rice Bran Arabinoxylan Compound and Tryptophan Metabolism on Quality of Life of Cancer Patients: A Secondary Analysis of the RBAC-QoL Study [0.03%]
米糠阿拉伯木聚糖化合物和色氨酸代谢对癌症患者生活质量的影响：RBAC-QoL研究的二次分析
Soo Liang Ooi,Benjamin Kimble,Benjamin S Pak et al.
Soo Liang Ooi et al.
Tryptophan metabolism, with its breakdown along the kynurenine pathway, is linked to the diminishing quality of life (QoL) of cancer patients. Rice bran arabinoxylan compound (RBAC) is a plant-based immunomodulator shown to improve the glob...
Cerebrospinal Fluid, Plasma Tryptophan, Kynurenine, and Kynurenate with Sleep Phenotypes: A Bidirectional Mendelian Randomization Analysis [0.03%]
睡眠表型的脑脊液、血浆色氨酸、犬尿酸和犬尿酸代谢物的 mendelian 随机化分析
Qin Xie,Guangya Liu,Xiaolan Liu
Qin Xie
Sleep is crucial for physiological regulation in humans and essential for sustaining life. Although melatonin, an intermediate in the tryptophan (TRP)-serotonin pathway, is widely explored as a modulator of the sleep-wake cycle, the associa...
The Effect of L-Tryptophan Intake on Dynamic Strength in Paralympic Powerlifting [0.03%]
L-色氨酸摄入对残奥力量举运动员动态峰值肌力的影响
Márcio Getirana-Mota,Felipe J Aidar,Raphael Fabricio de Souza et al.
Márcio Getirana-Mota et al.
Introduction: L-tryptophan supplementation has been studied in endurance sports with controversial results, and its influence on maximal strength sports remains largely unexplored. This study investigated whether L-trypto...
An Ecofriendly L-Tryptophan Containing UVA-1 Permissive Sunscreen Formulation: A Novel Approach for Inflammatory and Fibrosing Skin Diseases [0.03%]
一种新型环保L-色氨酸含UVA-1允许型防晒配方：炎症和纤维化皮肤病的治疗新思路
Rowland Noakes
Rowland Noakes
UVA-1 phototherapy, used in the management of psoriasis, atopic dermatitis and fibrosing skin disorders has been reported to mediate part of its therapeutic benefit via aryl hydrocarbon receptor (AHR) signalling. Accessibility to therapy re...
Altered Tryptophan-Kynurenine Pathway and Low-Grade Inflammation in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Insights from LC-MS/MS-Based Metabolite Profiling [0.03%]
基于LC-MS/MS的代谢物谱分析在代谢功能障碍相关脂肪性肝病(MASLD)中观察到的色氨酸-犬尿酸途径改变和低度炎症：新视野
Kübranur Ünal,Leyla İbrahimkhanlı,Mehmet Emre Erol et al.
Kübranur Ünal et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a multisystem disorder characterized by hepatic lipid accumulation, low-grade inflammation, and metabolic dysregulation. Although the kynurenine pathway has been implicated...
Accumulation of Quinolinic Acid Modulates the Pulmonary Immune Response During Influenza Infection [0.03%]
喹啉酸的积累可调节流感感染过程中的肺部免疫反应
Guillaume Pamart,Benjamin Hennart,Anaïs Ollivier et al.
Guillaume Pamart et al.
Influenza viruses cause a highly contagious, acute pulmonary disease that results in significant mortality each year. These infections trigger the production of interferons, known to induce the expression of the rate-limiting enzyme in the ...
Glucocorticoid Treatment Dampens Kynurenine Pathway Activation and Cytokine Release in Immune Stimulated Human Microglia [0.03%]
糖皮质激素治疗可抑制人类小胶质细胞中促炎刺激诱导的犬尿氨酸代谢通路激活及细胞因子释放
Martina Esposito Soccoio,Robert P Mason,Julien Devilliers et al.
Martina Esposito Soccoio et al.
As a first line of defence for the central nervous system (CNS), microglia play a critical role in maintaining homeostasis within the brain. Upon detection of damage or threats, activated cells release factors to communicate and potentiate ...