Carbamylated Erythropoietin: A Prospective Drug Candidate for Neuroprotection [0.03%]
carbamylated 促红细胞生成素：一种潜在的神经保护药物候选物
Jianmin Chen,Zheng Yang,Xiao Zhang
Jianmin Chen
Carbamylated erythropoietin (cEpo), which is neuroprotective but lacks hematopoietic activity, has been attracting rising concerns. However, the cellular and molecular mechanisms involved in the process of neuroprotection of cEpo are not we...
Yanling Zhang,Jianrui Song,Xiaojun Zhang et al.
Yanling Zhang et al.
La(3+) Alters the Response Properties of Neurons in the Mouse Primary Somatosensory Cortex to Low-Temperature Noxious Stimulation of the Dental Pulp [0.03%]
La(3+)通过改变小鼠牙髓低温度伤害性刺激初级体感皮层神经元的反应性质发挥镇痛作用
Yanjiao Jin
Yanjiao Jin
Although dental pain is a serious health issue with high incidence among the human population, its cellular and molecular mechanisms are still unclear. Transient receptor potential (TRP) channels are assumed to be involved in the generation...
Yuning Chen,Wen Dong,Li Tan et al.
Yuning Chen et al.
Extensins (EXTs) are hydroxyproline-rich glycoproteins (HRGPs) that are structural components of the plant primary cell wall. They are basic proteins and are highly glycosylated with carbohydrate accounting for >50% of their dry weight. Car...
Extracellular Matrix and Integrins in Embryonic Stem Cell Differentiation [0.03%]
胚胎干细胞分化中的细胞外基质和整合素受体
Han Wang,Xie Luo,Jake Leighton
Han Wang
Embryonic stem cells (ESCs) are pluripotent cells with great therapeutic potentials. The in vitro differentiation of ESC was designed by recapitulating embryogenesis. Significant progress has been made to improve the in vitro differentiatio...
Selective Regulation of Oocyte Meiotic Events Enhances Progress in Fertility Preservation Methods [0.03%]
选择性调节卵母细胞减数分裂事件可促进生育力保存方法的发展
Onder Celik,Nilufer Celik,Sami Gungor et al.
Onder Celik et al.
Following early embryonic germ cell migration, oocytes are surrounded by somatic cells and remain arrested at diplotene stage until luteinizing hormone (LH) surge. Strict regulation of both meiotic arrest and meiotic resumption during dorma...
Combined Efficacy of Gallic Acid and MiADMSA with Limited Beneficial Effects Over MiADMSA Against Arsenic-induced Oxidative Stress in Mouse [0.03%]
没食子酸与MiADMSA联合使用对阿舍利亚诱导的小鼠氧化应激的协同疗效及其有限的附加益处：与单独使用MiADMSA相比
Vidhu Pachauri,Sjs Flora
Vidhu Pachauri
Gallic acid is an organic acid known for its antioxidant and anticancer properties. The present study is focused on evaluating the role of gallic acid in providing better therapeutic outcomes against arsenic-induced toxicity. Animals pre-ex...
Production, Purification, and Identification of Cholest-4-en-3-one Produced by Cholesterol Oxidase from Rhodococcus sp. in Aqueous/Organic Biphasic System [0.03%]
水/有机两相体系中胆固醇脱氢酶产生、提纯及胆甾-4-烯-3-酮的鉴定
Ke Wu,Wei Li,Jianrui Song et al.
Ke Wu et al.
Cholest-4-en-3-one has positive uses against obesity, liver disease, and keratinization. It can be applied in the synthesis of steroid drugs as well. Most related studies are focused on preparation of cholest-4-en-3-one by using whole cells...
Withaferin A Inhibits STAT3 and Induces Tumor Cell Death in Neuroblastoma and Multiple Myeloma [0.03%]
Withaferin A通过抑制STAT3诱导神经母细胞瘤和多发性骨髓瘤细胞死亡
Lisette P Yco,Gabor Mocz,John Opoku-Ansah et al.
Lisette P Yco et al.
Signal transducer and activator of transcription 3 (STAT3) is an oncogenic transcription factor that has been implicated in many human cancers and has emerged as an ideal target for cancer therapy. Withaferin A (WFA) is a natural product wi...
Molecular Differences and Similarities Between Alzheimer's Disease and the 5XFAD Transgenic Mouse Model of Amyloidosis [0.03%]
阿尔茨海默病与5XFAD淀粉样脑炎转基因小鼠模型的分子异同点
Chera L Maarouf,Tyler A Kokjohn,Charisse M Whiteside et al.
Chera L Maarouf et al.
Transgenic (Tg) mouse models of Alzheimer's disease (AD) have been extensively used to study the pathophysiology of this dementia and to test the efficacy of drugs to treat AD. The 5XFAD Tg mouse, which contains two presenilin-1 and three a...