System Genetics Analysis Reveals Sex Differences in Human Aortic Smooth Muscle Gene Expression [0.03%]
系统遗传分析揭示人类主动脉平滑肌基因表达的性别差异
Sarah L Meng,Rita Anane-Wae,Ernest Diez Benavente et al.
Sarah L Meng et al.
Background: Coronary artery disease (CAD) is one of the leading causes of death worldwide. The buildup of atherosclerotic plaque, including lipids and cellular waste, characterizes this disease. Smooth muscle cells (SMCs)...
Mechanistic Insights of hsa-mir-301a Regulation by Tobacco Smoke in Lung Squamous Cell Carcinoma: Evidence From Bioinformatics Analysis [0.03%]
基于生物信息学分析的吸烟对肺鳞癌中hsa-mir-301a调控的机制研究
Vladimir O Pustylnyak,Alina M Perevalova,Lyudmila F Gulyaeva
Vladimir O Pustylnyak
MicroRNAs play a significant role in the development of cancers, including lung cancer. A recent study revealed that smoking, a key risk factor for lung cancer, increased the levels of hsa-mir-301a in the tumor tissues of patients with lung...
Regulatory Element Analysis and Comparative Genomics Study of Heavy Metal-Resistant Genes in the Complete Genome of Cupriavidus gilardii CR3 [0.03%]
铜绿假单胞菌CR3全基因组中重金属抗性基因的调控元件分析和比较基因组学研究
Duguma Dibbisa,Tadesse Daba,Seid Mohammed
Duguma Dibbisa
Environmental pollution has become a worldwide concern that requires rigorous efforts from all sectors of society to monitor, control, and remediate it. In environmental pollution control, Cupriavidus gilardii CR3 has become a model organis...
Haplotypic Distribution of SARS-CoV-2 Variants in Cases of Intradomiciliary Infection in the State of Rondônia, Western Amazon [0.03%]
罗龙尼亚州亚马逊西部家庭内感染病例的新冠病毒变异株单倍体型分布
Karolaine Santos Teixeira,Márlon Grégori Flores Custódio,Gabriella Sgorlon et al.
Karolaine Santos Teixeira et al.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a high transmissibility profile which favors the accumulation of mutations along its genome, providing the emergence of new variants. In this context, haplotype studies have a...
The TWW Growth Model and Its Application in the Analysis of Quantitative Polymerase Chain Reaction [0.03%]
TWW生长模型及其在定量聚合酶链式反应分析中的应用
M Tabatabai,D Wilus,K P Singh et al.
M Tabatabai et al.
It is necessary to accurately capture the growth trajectory of fluorescence where the best fit, precision, and relative efficiency are essential. Having this in mind, a new family of growth functions called TWW (Tabatabai, Wilus, Wallace) w...
Unlocking Benzosampangine's Potential: A Computational Approach to Investigating, Its Role as a PD-L1 Inhibitor in Tumor Immune Evasion via Molecular Docking, Dynamic Simulation, and ADMET Profiling [0.03%]
苯扎明潜力探秘：基于计算方法探讨其作为PD-L1抑制剂在肿瘤免疫逃逸中的作用以及分子对接、动态模拟及ADMET评价
Abderrahim Ait Ouchaoui,Salah Eddine El Hadad,Marouane Aherkou et al.
Abderrahim Ait Ouchaoui et al.
The interaction between programmed cell death protein 1 (PD-1) and its ligand PD-L1 plays a crucial role in tumor immune evasion, presenting a critical target for cancer immunotherapy. Despite being effective, current monoclonal antibodies ...
Drug Repositioning for Scorpion Envenomation Treatment Through Dual Inhibition of Chlorotoxin and Leiurotoxin [0.03%]
通过氯毒素和莱乌毒素联合抑制重新定位药物治疗蝎子蜇伤
Gaouzi Zainab,Abbou Hanane,Zegrari Razana et al.
Gaouzi Zainab et al.
Scorpion envenomation, a grave public health concern, is primarily driven by the potent neurotoxins chlorotoxin and leiurotoxin present in Leiurus species venom. Developing effective treatments is crucial to mitigate its impact. Utilizing a...
Charting Peptide Shared Sequences Between 'Diabetes-Viruses' and Human Pancreatic Proteins, Their Structural and Autoimmune Implications [0.03%]
“糖尿病病毒”与人胰蛋白之间肽共享序列的图谱及其结构和自身免疫学含义
Stephen A James,Istifanus A Joshua
Stephen A James
Diabetes mellitus (DM) is a metabolic syndrome characterized by hyperglycaemia, polydipsia, polyuria, and weight loss, among others. The pathophysiology for the disorders is complex and results in pancreatic abnormal function. Viruses have ...
Karamveer,Yasin Uzun
Karamveer
Gene regulatory networks are powerful tools for modeling genetic interactions that control the expression of genes driving cell differentiation, and single-cell sequencing offers a unique opportunity to build these networks with high-resolu...
Conyza bonariensis (L.) Impact on Carbohydrate Metabolism and Oxidative Stress in a Type 2 Diabetic Rat Model [0.03%]
Conyza bonariensis(L.)对2型糖尿病大鼠糖代谢和氧化应激的影响
Imtiaz Mustafa,Shahzad Irfan,Ghulam Hussain et al.
Imtiaz Mustafa et al.
This study was conducted to assess the possible antidiabetic potential of Conyza bonariensis by employing in vitro as well as in vivo assessments. The dried plant material was extracted in methanol, ethanol, and water. The in vitro results ...