In Silico Identification of Potential Biomarker-Binding Proteins for Noninvasive Diagnosis of Buruli Ulcer Disease [0.03%]
计算识别 buruli 溃疡病非侵入性诊断的潜在生物标志物结合蛋白
Erica A Akanko,Clement Agoni,George Hanson et al.
Erica A Akanko et al.
Buruli ulcer (BU) is a necrotizing skin disease caused by Mycobacterium ulcerans that produces a virulent lipid toxin, mycolactone, which is detectable in urine. Current diagnostics are time-consuming and require specialized expertise, ofte...
SeqExpressionAnalyser: An R Package for Automated End-to-End RNA-Seq Analysis From Reads to Differential Expression [0.03%]
SeqExpressionAnalyser：一个R包实现从原始读段到差异表达的端到端自动化RNA-seq分析
Sanae Esskhayry,Ouafae Kaissi,Fouzia Radouani et al.
Sanae Esskhayry et al.
Differential gene expression analysis of RNA Sequencing (RNA-Seq) data is crucial for understanding key patterns of gene regulation and enhancing our knowledge of biological processes and diseases. The workflow of this analysis comprises qu...
Integrated Network Analysis Reveals a Directly Regulatory Network of FOXM1 Associated With the Cell Cycle in Lung Adenocarcinoma [0.03%]
整合网络分析揭示了FOXM1在肺癌腺癌中的直接调控网络及其与细胞周期的关系
Yuetao Zhao,Diangang Chen
Yuetao Zhao
Lung adenocarcinoma (LUAD) has emerged as both the most frequently diagnosed malignancy and the predominant contributor to cancer-related mortality worldwide. Current clinical evidence indicates that a significant proportion of LUAD cases e...
In Silico Identification of Lepiotaprocerin C as a Promising PIM-1 Kinase Inhibitor: An Integrated Docking, Molecular Dynamics, MM/PBSA, QSAR, and ADMET Study [0.03%]
基于计算的Lepiotaprocerin C作为有前景的PIM-1激酶抑制剂的研究：对接，分子动力学，MM/PBSA，QSAR和ADMET综合研究
Keshava Ks,Faten Qais Ibraheem,Shankar Thapa et al.
Keshava Ks et al.
Proviral Integration site for Moloney murine leukemia virus-1 (PIM-1) kinase, a serine/threonine kinase overexpressed in various malignancies, plays a critical role in promoting cell survival and proliferation, making it a promising target ...
Exploration of Natural Products for Targeting IDH1/2 Mutations in Acute Myeloid Leukemia Through Ligand-Based Pharmacophore Screening, Docking, ADME-T, and Molecular Dynamic Simulation Approaches [0.03%]
基于配体的药效团筛选、对接、ADME-T及分子动力学模拟方法探索针对急性髓系白血病IDH1/2突变的天然产物研究
Uddalak Das,Dheemanth Reddy Regati,Jitendra Kumar et al.
Uddalak Das et al.
Background: Mutations in isocitrate dehydrogenase 1 (IDH1) and 2 (IDH2) are prevalent drivers of acute myeloid leukemia (AML). While targeted therapies exist, resistance can emerge. This study explored the potential of na...
Designing a Multi-Epitope Vaccine Against HPV 16, 18, 33, and 45 Targeting L1 and E7 Proteins: An Immunoinformatics Approach for Cervical Cancer Prevention and Therapy [0.03%]
基于免疫信息学方法设计用于宫颈癌预防和治疗的HPV 16、18、33和45型多表位疫苗（靶向L1和E7蛋白）
Md Touki Tahamid Tusar,Niamul Haq,Hafizur Rahman Gazi et al.
Md Touki Tahamid Tusar et al.
Cervical cancer, induced by human papillomavirus (HPV), ranks as the fourth most prevalent malignancy among women globally. Unfortunately, existing prophylactic vaccines lack therapeutic efficacy. This study aimed to design a multi-epitope ...
A Deep Learning Model to Predict the ncRNA-Protein Interactions Based on Sequences Information Only [0.03%]
基于序列信息预测ncRNA-蛋白质相互作用的深度学习模型
Maha Fm Sewailem,Muhammad Arif,Tanvir Alam
Maha Fm Sewailem
Noncoding RNAs (ncRNAs) play significant roles in multiple fundamental biological processes, in particular, ncRNAs interactions provide valuable insights into protein synthesis, controlling gene expression, RNA processing, regulation of loc...
Integrated Genomic Approaches to Elucidate the Genetic Basis of Brugada Syndrome in Taiwanese Patients [0.03%]
整合基因组方法阐明台湾Brugada综合征患者的遗传基础
Chayanika Goswami,Jyh-Ming Jimmy Juang,Tzu-Pin Lu et al.
Chayanika Goswami et al.
Brugada syndrome (BrS) is a rare cardiac arrhythmia with a complex and largely unexplained genetic basis. In this study, we analysed genomic data from 214 Taiwanese BrS cases and 1316 controls to uncover susceptibility loci using genome-wid...
Evaluation of the Antigenic Potential of Epitopes Derived From Leishmania braziliensis [0.03%]
利什曼原虫抗原表位的抗原潜力评估
Ntc Costa,Ams Pereira,C C Silva et al.
Ntc Costa et al.
Background: Leishmaniasis is a neglected tropical disease caused by protozoa of the genus Leishmania, predominantly affecting populations with limited socioeconomic resources. Leishmania (V.) braziliensis is one of the primary etiological a...
Identification of Potent HDAC6 Inhibitors for Breast Cancer Through Multi-Stage In Silico Modeling [0.03%]
基于多阶段计算机模拟的乳腺癌HDAC6抑制剂识别研究
Vaishali Pankaj,Inderjeet Bhogal,Sudeep Roy
Vaishali Pankaj
Histone deacetylases (HDACs) are essential epigenetic regulators, with HDAC6 overexpression linked to estrogen receptor (ER) activity and breast cancer progression. While several HDAC6 inhibitors have been investigated, their clinical succe...