Genomic Insights Into Bacillus thuringiensis Strain JSd1 From Bangladesh: A Whole Genome Sequencing Approach [0.03%]
全基因组测序揭示芽孢杆菌以色列变种JSd1（来源于孟加拉国）的基因组见解
Md Abdul Bari,Dipta Chandra Pal,Md Al Muid Khan et al.
Md Abdul Bari et al.
Bacillus thuringiensis (Bt) is a well-known entomopathogenic bacterium widely used in biopesticide formulations due to its diverse arsenal of insecticidal toxins and environmental adaptability. However, the genetic diversity and virulence p...
ArchetypeShift: An R Package Integrating KEGG-Informed Pathway Analysis and IPA-Derived Functional Predictions for Validation of Single-Cell Archetypes [0.03%]
ArchetypeShift包：一个整合KEGG通路分析和IPA功能预测以验证单细胞亚型的R语言软件包
Adam P Wilson,Hala Chaaban,Kathryn Y Burge
Adam P Wilson
Functional archetype analysis of single-cell RNA-sequencing (scRNA-seq) data is important because clustering of cell types is often nuanced and inexact. Intermediate phenotypes exist that are difficult to account for in these analyses, part...
A Comprehensive In-Silico Pipeline for the Discovery of Non-toxic, Stable Antimicrobial Peptides From Databases for Targeting Multi-Drug Resistant K. pneumoniae [0.03%]
一种全面的计算流水线，用于从数据库中发现无毒、稳定的抗菌肽以针对多重耐药的肺炎克雷伯菌(K.pneumoniae)
Pranab Dev Sharma,Abdullah Al Noman,Md Al Amin Talukder et al.
Pranab Dev Sharma et al.
The rapid emergence of multidrug-resistant Klebsiella pneumoniae has significantly reduced the effectiveness of conventional antibiotics, highlighting the need for alternative therapeutic strategies. This study employed a comprehensive in s...
Integrative Analysis of Intestinal Transcriptomes Underscores C2 Upregulation in IBD, AIG, EoE, and CRC [0.03%]
肠道转录组整合分析强调C2在IBD、AIG、EoE和CRC中升高
Arman Mokaram Doust Delkhah
Arman Mokaram Doust Delkhah
Intestinal transcriptomic data encompass substantial value in studying inflammatory bowel disease. By analyzing intestinal gene expression profiles, this study aimed to discover transcripts exhibiting diagnostic efficacy for IBD. Intestinal...
Integrated in Silico and in Vitro Bioactivity Profiling of Selected South African Plant Constituents Against Carbohydrate-Metabolizing Enzymes for Type 2 Diabetes Therapy [0.03%]
选择南非植物成分的综合计算机和体外生物活性分析以寻找治疗2型糖尿病的碳水化合物代谢酶抑制剂
Oluwaseye Adedirin,Saheed Sabiu
Oluwaseye Adedirin
The increasing global burden of Type 2 diabetes mellitus (T2DM) and the side effects of conventional drugs have driven the search for natural therapeutic alternatives. This study investigates the antidiabetic potential of South African esse...
Unveiling Carbonic Anhydrase VIII, X, XI Expression in Cancer and Neurological Diseases Through Integrated Bioinformatics Approaches [0.03%]
整合生物信息学方法揭示碳酸酐酶 VIII、X、XI 在癌症和神经性疾病中的表达
Ratul Bhowmik,Rajarshi Ray,Ashok Aspatwar
Ratul Bhowmik
Carbonic anhydrases are metalloenzymes found both in vertebrates and invertebrates. The CAs catalyze the reversible hydration of CO2 to bicarbonate and H+ ions and play a significant role in respiration, transport of CO2, pH homeostasis, el...
Bioinformatics Analysis of the PSD Gene Family: Metastasis and Prognosis in HCC [0.03%]
PSD基因家族的生物信息学分析及其在肝癌转移和预后中的作用
Hongyi Sun,Minghao Guo,Wei Liu
Hongyi Sun
Hepatocellular carcinoma (HCC) is a common malignant tumor with a poor prognosis for advanced metastasis while there is currently a lack of prognostic markers and effective therapeutic targets in this area. The PSD gene family, comprising f...
Tracing the Evolutionary Dynamics and the Transcriptional Partitioning of Terpene Synthase Gene Family in Coffea arabica and Its Diploid Progenitors [0.03%]
Coffea arabica及其二倍体祖先中萜类合酶基因家族的转录分隔及进化动态分析
Makarim Elfadil M Osman,Mohanad A Ibrahim,Rieham Sallah H Osman et al.
Makarim Elfadil M Osman et al.
Terpenes represent a diverse class of plant secondary metabolites that play important roles in development, ecological interactions, and aroma, and are synthesized by the terpene synthase (TPS) gene family. To investigate the evolutionary h...
Hidden in the Pangenome? Machine Learning-Driven Discovery of Antimicrobial Potential in Corynebacterium glutamicum [0.03%]
隐藏在泛基因组中？机器学习驱动的发现天冬氨酸棒杆菌抗菌潜能
Sk Injamamul Islam,Khandker Shahed,Mst Mahmuda Parvin et al.
Sk Injamamul Islam et al.
Antimicrobial resistance poses an increasing global challenge, driving the urgent need for alternative strategies to identify novel therapeutic agents. Microbial natural products encoded by biosynthetic gene clusters (BGCs) remain among the...
In silico Design and Analysis of Engineered Proteins Containing Multi-Epitope and Immunodominant Domains Derived From Rickettsia prowazekii A ntigens [0.03%]
基于康氏立克次体抗原的多表位与优势B细胞表位工程蛋白质的计算机设计和分析
Massrehaw Assnakew Abebe,Desye Melese Sisay,Abebaw Fekadu et al.
Massrehaw Assnakew Abebe et al.
Epidemic louse-borne typhus caused by Rickettsia prowazekii and transmitted by the human body louse, remains a major public health threat in many developing regions. Historical records indicate that outbreaks have resulted in up to million ...