Integrating AI-Based Clustering, Molecular Dynamics, and Binding Energy Analysis to Elucidate Conformational Dynamics and Binding Selectivity in Extracellular Signal-Regulated Kinases 1 and 2 Complexes [0.03%]
基于人工智能的聚类、分子动力学和结合能分析在细胞外信号调节激酶1和2复合物构象动态学和结合选择性阐释中的整合研究
Abdullah Alqahtani
Abdullah Alqahtani
The development of selective small-molecule inhibitors against extracellular signal-regulated kinases 1 and 2 (ERK1/2) remains a major challenge due to their high structural similarity and conformational flexibility. In this study, we combi...
Comprehensive Pan-Cancer Analysis Reveals RNF20 as a Candidate Prognostic and Diagnostic Biomarker [0.03%]
全面的泛癌分析揭示RNF20作为潜在预后和诊断生物标志物候选人
Jiangbo Liang,Dong Wang,Lei Wang et al.
Jiangbo Liang et al.
RNF20 is a RING-domain E3 ubiquitin ligase that mediates monoubiquitination of histone H2B at lysine 120 and plays important roles in transcriptional elongation, repair of DNA double-strand breakages, chromatin homeostasis as well as tumor ...
Leveraging Artificial Intelligence to Advance Bioinformatics in Africa: Opportunities, Challenges, and Ethical Considerations in Combating Antimicrobial Resistance [0.03%]
利用人工智能推动非洲生物信息学的发展：应对抗菌药物耐药性的机会、挑战和伦理考量
Beatus Lyimo
Beatus Lyimo
Africa continues to bear a disproportionate burden of infectious diseases, particularly antimicrobial-resistant (AMR) infections, which significantly affect public health and socio-economic development. Addressing these complex health threa...
Computational and Experimental Characterization of Mycobacterium marinum β-Carbonic Anhydrase Inhibitors [0.03%]
计算和实验表征分枝杆菌海洋分支菌β-碳酸酐酶抑制剂
Niaz Morshed,Md Selim Reza,Ratul Bhowmik et al.
Niaz Morshed et al.
Carbonic anhydrases in Mycobacterium tuberculosis are increasingly recognized as promising therapeutic targets in drug-resistant tuberculosis. In this study, a homology model of β-carbonic anhydrase was developed using the closely related ...
Zoon0PredV: Potential Virus Species Crossover Prediction Using Convolutional Neural Networks and Viral Protein Sequence Patterns [0.03%]
基于卷积神经网络和病毒蛋白序列模式的潜在病毒物种跨界预测(Zoon0PredV)
Rudolph Abel Serage,Clement Nthambazale Nyirenda,Taiwo Gabriel Omomule et al.
Rudolph Abel Serage et al.
Biomedical science has made substantial progress toward diagnosing, understanding the pathogenesis, and treating various causative agents of infectious disease. However, novel microbial pathogens continue to emerge, and existing pathogens c...
Riccardo Bollini,Valeria Cento
Riccardo Bollini
The identification of plasmids from assembled genomes is well supported by numerous different tools, yet very few incorporate a plasmid copy number estimation step. This limits a comprehensive plasmid analysis, often leaving researchers to ...
In Silico Identification of Potential Biomarker-Binding Proteins for Noninvasive Diagnosis of Buruli Ulcer Disease [0.03%]
计算识别 buruli 溃疡病非侵入性诊断的潜在生物标志物结合蛋白
Erica A Akanko,Clement Agoni,George Hanson et al.
Erica A Akanko et al.
Buruli ulcer (BU) is a necrotizing skin disease caused by Mycobacterium ulcerans that produces a virulent lipid toxin, mycolactone, which is detectable in urine. Current diagnostics are time-consuming and require specialized expertise, ofte...
SeqExpressionAnalyser: An R Package for Automated End-to-End RNA-Seq Analysis From Reads to Differential Expression [0.03%]
SeqExpressionAnalyser：一个R包实现从原始读段到差异表达的端到端自动化RNA-seq分析
Sanae Esskhayry,Ouafae Kaissi,Fouzia Radouani et al.
Sanae Esskhayry et al.
Differential gene expression analysis of RNA Sequencing (RNA-Seq) data is crucial for understanding key patterns of gene regulation and enhancing our knowledge of biological processes and diseases. The workflow of this analysis comprises qu...
Integrated Network Analysis Reveals a Directly Regulatory Network of FOXM1 Associated With the Cell Cycle in Lung Adenocarcinoma [0.03%]
整合网络分析揭示了FOXM1在肺癌腺癌中的直接调控网络及其与细胞周期的关系
Yuetao Zhao,Diangang Chen
Yuetao Zhao
Lung adenocarcinoma (LUAD) has emerged as both the most frequently diagnosed malignancy and the predominant contributor to cancer-related mortality worldwide. Current clinical evidence indicates that a significant proportion of LUAD cases e...
In Silico Identification of Lepiotaprocerin C as a Promising PIM-1 Kinase Inhibitor: An Integrated Docking, Molecular Dynamics, MM/PBSA, QSAR, and ADMET Study [0.03%]
基于计算的Lepiotaprocerin C作为有前景的PIM-1激酶抑制剂的研究：对接，分子动力学，MM/PBSA，QSAR和ADMET综合研究
Keshava Ks,Faten Qais Ibraheem,Shankar Thapa et al.
Keshava Ks et al.
Proviral Integration site for Moloney murine leukemia virus-1 (PIM-1) kinase, a serine/threonine kinase overexpressed in various malignancies, plays a critical role in promoting cell survival and proliferation, making it a promising target ...