HMM_RA: an improved method for alpha-helical transmembrane protein topology prediction [0.03%]
改进的α-螺旋跨膜蛋白拓扑预测方法HMM-ra
Jing Hu,Changhui Yan
Jing Hu
alpha-helical transmembrane (TM) proteins play important and diverse functional roles in cells. The ability to predict the topology of these proteins is important for identifying functional sites and inferring function of membrane proteins....
Characterization of non-trivial neighborhood fold constraints from protein sequences using generalized topohydrophobicity [0.03%]
基于广义构象拓扑水溶性的蛋白质序列邻近域折迭约束的非平凡性研究
Guillaume Fourty,Isabelle Callebaut,Jean-Paul Mornon
Guillaume Fourty
Prediction of key features of protein structures, such as secondary structure, solvent accessibility and number of contacts between residues, provides useful structural constraints for comparative modeling, fold recognition, ab-initio fold ...
Coarse-grained models reveal functional dynamics--I. Elastic network models--theories, comparisons and perspectives [0.03%]
粗粒化模型揭示功能动态效应-I. 弹性网络模型-理论、比较和展望
Lee-Wei Yang,Choon-Peng Chng
Lee-Wei Yang
In this review, we summarize the progress on coarse-grained elastic network models (CG-ENMs) in the past decade. Theories were formulated to allow study of conformational dynamics in time/space frames of biological interest. Several highlig...
Adam T Zemla,Carol L Ecale Zhou
Adam T Zemla
We compared structure alignments generated by several protein structure comparison programs to determine whether existing methods would satisfactorily align residues at a highly conserved position within an immunogenic loop in ribosome inac...
Proteomic analysis in diabetic cardiomyopathy using bioinformatics approach [0.03%]
基于生物信息学方法的心肌病蛋白质组分析
Allam Appa Rao,Hanuman Thota,Ramamurthy Adapala et al.
Allam Appa Rao et al.
Diabetic cardiomyopathy is a distinct clinical entity that produces asymptomatic heart failure in diabetic patients without evidence of coronary artery disease and hypertension. Abnormalities in diabetic cardiomyopathy include: myocardial h...
Beyond Field Effect: Analysis of Shrunken Centroids in Normal Esophageal Epithelia Detects Concomitant Esophageal Adenocarcinoma [0.03%]
场效应以外：正常食道上皮中缩小中心的分析可检测并发食管腺癌
Florin M Selaru,Suna Wang,Jing Yin et al.
Florin M Selaru et al.
BACKGROUND AND AIMS: Because of the extremely low neoplastic progression rate in Barrett's esophagus, it is difficult to diagnose patients with concomitant adenocarcinoma early in their disease course. If biomarkers existed in normal squamo...
The HapMap Resource is Providing New Insights into Ourselves and its Application to Pharmacogenomics [0.03%]
HapMap资源为我们带来的新启示及在药物基因学中的应用
Wei Zhang,Mark J Ratain,M Eileen Dolan
Wei Zhang
The exploration of quantitative variation in complex traits such as gene expression and drug response in human populations has become one of the major priorities for medical genetics. The International HapMap Project provides a key resource...
Rarity of Somatic Mutation and Frequency of Normal Sequence Variation Detected in Sporadic Colon Adenocarcinoma Using High-Throughput cDNA Sequencing [0.03%]
高通量cDNA测序检测散发性结肠腺癌中体细胞突变罕见和正常序列变异频率
Takatsugu Kan,Bogdan C Paun,Yuriko Mori et al.
Takatsugu Kan et al.
We performed high-throughput cDNA sequencing in colorectal adenocarcinoma and matching normal colorectal epithelium. All six hundred three genes in the UCSC database that were expressed in colon cancers and contained open reading frames of ...
Resistify: A Novel NLR Classifier That Reveals Helitron-Associated NLR Expansion in Solanaceae [0.03%]
Resistify：一种新颖的NLR分类器，可揭示Solanaceae中由Helitron相关的NLR扩张现象
Nucleotide-binding domain leucine-rich repeat (NLR) proteins are a key component of the plant innate immune system. In plant genomes, NLRs exhibit considerable presence/absence variation and sequence diversity. Recent advances in sequencing...