Nadine Schuurman,Agnieszka Leszczynski
Nadine Schuurman
The past twenty years have witnessed an explosion of biological data in diverse database formats governed by heterogeneous infrastructures. Not only are semantics (attribute terms) different in meaning across databases, but their organizati...
Coarse-grained models reveal functional dynamics--II. Molecular dynamics simulation at the coarse-grained level--theories and biological applications [0.03%]
粗粒化模型揭示功能动力学-II. 粗粒化的分子动力学模拟-理论与生物学应用
Choon-Peng Chng,Lee-Wei Yang
Choon-Peng Chng
Molecular dynamics (MD) simulation has remained the most indispensable tool in studying equilibrium/non-equilibrium conformational dynamics since its advent 30 years ago. With advances in spectroscopy accompanying solved biocomplexes in gro...
Distribution of polymorphic and non-polymorphic microsatellite repeats in Xenopus tropicalis [0.03%]
热带爪蟾多态和非多态微卫星重复序列的分布规律
Zhenkang Xu,Laura Gutierrez,Matthew Hitchens et al.
Zhenkang Xu et al.
The results of our bioinformatics analysis have found over 91,000 di-, tri-, and tetranucleotide microsatellites in our survey of 25% of the X. tropicalis genome, suggesting there may be over 360,000 within the entire genome. Within the X. ...
A new test statistic based on shrunken sample variance for identifying differentially expressed genes in small microarray experiments [0.03%]
一种基于压缩样本方差的检验统计量用于小规模微阵列实验中差异表达基因识别的新方法
Akihiro Hirakawa,Yasunori Sato,Chikuma Hamada et al.
Akihiro Hirakawa et al.
Choosing an appropriate statistic and precisely evaluating the false discovery rate (FDR) are both essential for devising an effective method for identifying differentially expressed genes in microarray data. The t-type score proposed by Pa...
Searching for factors that distinguish disease-prone and disease-resistant prions via sequence analysis [0.03%]
通过序列分析寻找区分易感和抗病型普里昂的因素
Kanaka Durga Kedarisetti,Scott Dick,Lukasz Kurgan
Kanaka Durga Kedarisetti
The exact mechanisms of prion misfolding and factors that predispose an individual to prion diseases are largely unknown. Our approach to identifying candidate factors in-silico relies on contrasting the C-terminal domain of PrP(C) sequence...
A unified discussion on the concept of score functions used in the context of nonparametric linkage analysis [0.03%]
非参数连锁分析中评分函数概念的统一讨论
Lars Angquist
Lars Angquist
In this article we try to discuss nonparametric linkage (NPL) score functions within a broad and quite general framework. The main focus of the paper is the structure, derivation principles and interpretations of the score function entity i...
Utility of computational methods to identify the apoptosis machinery in unicellular eukaryotes [0.03%]
计算方法在识别单细胞真核生物凋亡装置中的应用价值
Pierre Marcel Durand,Theresa Louise Coetzer
Pierre Marcel Durand
Apoptosis is the phenotypic result of an active, regulated process of self-destruction. Following various cellular insults, apoptosis has been demonstrated in numerous unicellular eukaryotes, but very little is known about the genes and pro...
Effects of feeding periods of high cholesterol and saturated fat diet on blood biochemistry and hydroxyproline fractions in rabbits [0.03%]
高胆固醇和饱和脂肪膳食喂养对兔血生化及羟脯氨酸组分的影响
Mohamed A K Abdelhalim,N J Siiddiqi,A S Alhomida et al.
Mohamed A K Abdelhalim et al.
Hypercholesterolemia and hypertriglyceridemia are considered as important risk factors during the atherosclerotic process. The aim of the present investigation was to study the total cholesterol (TC), low-density lipoprotein cholesterol (LD...
Yurong Xin,Giulio Quarta,Hin Hark Gan et al.
Yurong Xin et al.
Recent studies of mammalian transcriptomes have identified numerous RNA transcripts that do not code for proteins; their identity, however, is largely unknown. Here we explore an approach based on sequence randomness patterns to discern dif...