Including Functional Annotations and Extending the Collection of Structural Classifications of Protein Loops (ArchDB) [0.03%]
包含功能注释并扩展蛋白质环的结构分类集(ArchDB)
Antoni Hermoso,Jordi Espadaler,E Enrique Querol et al.
Antoni Hermoso et al.
Loops represent an important part of protein structures. The study of loop is critical for two main reasons: First, loops are often involved in protein function, stability and folding. Second, despite improvements in experimental and comput...
Paul C D Johnson,Daniel T Haydon
Paul C D Johnson
Microsatellite genetic marker data are exploited in a variety of fields, including forensics, gene mapping, kinship inference and population genetics. In all of these fields, inference can be thwarted by failure to quantify and account for ...
Screening the single nucleotide polymorphisms in patients with internal carotid artery stenosis by oligonucleotide-based custom DNA array [0.03%]
采用寡核苷酸定制DNA芯片筛查颈内动脉狭窄患者单核苷酸多态性
Kenji Nakai,Mayu Oyanagi,Jiro Hitomi et al.
Kenji Nakai et al.
Early screening of individuals considered to be at risk for severe internal carotid artery (ICA) stenosis is an important strategy for preventing ischemic cerebral stroke. The purpose of this study is to screening candidate single nucleotid...
GSMA: Gene Set Matrix Analysis, An Automated Method for Rapid Hypothesis Testing of Gene Expression Data [0.03%]
GSMA：基因集矩阵分析，一种用于快速假设检验的基因表达数据的自动化方法
Chris Cheadle,Tonya Watkins,Jinshui Fan et al.
Chris Cheadle et al.
Background: Microarray technology has become highly valuable for identifying complex global changes in gene expression patterns. The assignment of functional information to these complex patterns remains a challenging tas...
Prediction of functional class of proteins and peptides irrespective of sequence homology by support vector machines [0.03%]
支持向量机预测序列同源性以外的蛋白质和肽的功能类别
Zhi Qun Tang,Hong Huang Lin,Hai Lei Zhang et al.
Zhi Qun Tang et al.
Various computational methods have been used for the prediction of protein and peptide function based on their sequences. A particular challenge is to derive functional properties from sequences that show low or no homology to proteins of k...
Using a seed-network to query multiple large-scale gene expression datasets from the developing retina in order to identify and prioritize experimental targets [0.03%]
利用种子网络查询大规模基因表达数据集以识别和优先考虑视网膜发育的实验目标
Laura A Hecker,Timothy C Alcon,Vasant G Honavar et al.
Laura A Hecker et al.
Understanding the gene networks that orchestrate the differentiation of retinal progenitors into photoreceptors in the developing retina is important not only due to its therapeutic applications in treating retinal degeneration but also bec...
Identification of the RGG box motif in Shadoo: RNA-binding and signaling roles? [0.03%]
Shadoo中RGG框基序的鉴定：rna结合和信号转导作用？
Susan M Corley,Jill E Gready
Susan M Corley
Using comparative genomics and in-silico analyses, we previously identified a new member of the prion-protein (PrP) family, the gene SPRN, encoding the protein Shadoo (Sho), and suggested its functions might overlap with those of PrP. Exten...
Identification and investigation of Drosophila postsynaptic density homologs [0.03%]
果蝇后突触密度同源物的鉴定与研究
Faith L W Liebl,David E Featherstone
Faith L W Liebl
AMPA receptors are responsible for fast excitatory transmission in the CNS and the trafficking of these receptors has been implicated in LTP and learning and memory. These receptors reside in the postsynaptic density, a network of proteins ...
IMAGE: a new tool for the prediction of transcription factor binding sites [0.03%]
图像：转录因子结合位点预测的新工具
R Casilli,A Marongiu,S Melchionna et al.
R Casilli et al.
IMAGE is an application tool, based on the vector quantization method, aiding the discovery of nucleotidic sequences corresponding to Transcription Factor binding sites. Starting from the knowledge of regulation regions of a number of co-ex...
Gene copy number analysis for family data using semiparametric copula model [0.03%]
基于半参数Copula模型的家系数据基因拷贝数分析方法研究
Ao Yuan,Guanjie Chen,Zhong-Cheng Zhou et al.
Ao Yuan et al.
Gene copy number changes are common characteristics of many genetic disorders. A new technology, array comparative genomic hybridization (a-CGH), is widely used today to screen for gains and losses in cancers and other genetic diseases with...