An Efficient Method to Identify Conditionally Activated Transcription Factors and their Corresponding Signal Transduction Pathway Segments [0.03%]
一种有效鉴别条件激活型转录因子及其相应信号传导通路片段的方法
Haiyan Hu
Haiyan Hu
A signal transduction pathway (STP) is a cascade composed of a series of signal transferring steps, which often activate one or more transcription factors (TFs) to control the transcription of target genes. Understanding signaling pathways ...
Gene expression based leukemia sub-classification using committee neural networks [0.03%]
基于基因表达的白血病亚型分类的委员会神经网络方法研究
Mihir S Sewak,Narender P Reddy,Zhong-Hui Duan
Mihir S Sewak
Analysis of gene expression data provides an objective and efficient technique for sub-classification of leukemia. The purpose of the present study was to design a committee neural networks based classification systems to subcategorize leuk...
Marcin Kierczak,Krzysztof Ginalski,Michał Dramiński et al.
Marcin Kierczak et al.
Reverse transcriptase (RT) is a viral enzyme crucial for HIV-1 replication. Currently, 12 drugs are targeted against the RT. The low fidelity of the RT-mediated transcription leads to the quick accumulation of drug-resistance mutations. The...
Sequence Analysis of the Full-length cDNA and Protein Structure Homology Modeling of FABP2 from Paralichthys Olivaceus [0.03%]
仿刺参FABP2基因组结构及蛋白质三维同源模建与序列分析
Xiaowu Chen,Zhiyi Shi
Xiaowu Chen
Using zebrafish intestinal fatty acid-binding protein 2 (FABP2) mRNA sequence as the initial query probe, four highly homologous Paralichthys olivaceus EST sequences were retrieved from Genbank database. The assembled full-length cDNA conta...
Nicolas Carels,Diego Frías
Nicolas Carels
In this report, we compared the success rate of classification of coding sequences (CDS) vs. introns by Codon Structure Factor (CSF) and by a method that we called Universal Feature Method (UFM). UFM is based on the scoring of purine bias (...
Jan A Hiss,Gisbert Schneider
Jan A Hiss
Bacterial autotransporters represent a diverse family of proteins that autonomously translocate across the inner membrane of Gram-negative bacteria via the Sec complex and across the outer bacterial membrane. They often possess exceptionall...
Chun-Liang Lin,Yuan-Wei Liu,Chia-Hua Chuang
Chun-Liang Lin
Signal transduction networks of biological systems are highly complex. How to mathematically describe a signal transduction network by systematic approaches to further develop an appropriate and effective control strategy is attractive to c...
Identifying Stress Transcription Factors Using Gene Expression and TF-Gene Association Data [0.03%]
基于基因表达和转录因子-基因关联数据的应力转录因子识别方法研究
Wei-Sheng Wu,Bor-Sen Chen
Wei-Sheng Wu
Unicellular organisms such as yeasts have evolved to survive environmental stresses by rapidly reorganizing the genomic expression program to meet the challenges of harsh environments. The complex adaptation mechanisms to stress remain to b...
Peptide vocabulary analysis reveals ultra-conservation and homonymity in protein sequences [0.03%]
肽词汇分析揭示蛋白质序列中的超保守性和同形性
Derek Gatherer
Derek Gatherer
A new algorithm is presented for vocabulary analysis (word detection) in texts of human origin. It performs at 60%-70% overall accuracy and greater than 80% accuracy for longer words, and approximately 85% sensitivity on Alice in Wonderland...
D Stauffer
D Stauffer
This review deals with computer simulation of biological aging, particularly with the Penna model of 1995. They are based on the mutation accumulation theory of half a century ago. The results agree well with demographical reality, and also...