Divya P Syamaladevi,James A Spudich,R Sowdhamini
Divya P Syamaladevi
The myosin superfamily is a versatile group of molecular motors involved in the transport of specific biomolecules, vesicles and organelles in eukaryotic cells. The processivity of myosins along an actin filament and transport of intracellu...
A novel approach for the simultaneous analysis of common and rare variants in complex traits [0.03%]
一种同时分析复杂性状常见变异和稀有变异的新方法
Ao Yuan,Guanjie Chen,Yanxun Zhou et al.
Ao Yuan et al.
Genome-wide association studies (GWAS) have been successful in detecting common genetic variants underlying common traits and diseases. Despite the GWAS success stories, the percent trait variance explained by GWAS signals, the so called "m...
Shaneka S Simmons,Raphael D Isokpehi,Shyretha D Brown et al.
Shaneka S Simmons et al.
Rhodopseudomonas palustris, a nonsulphur purple photosynthetic bacteria, has been extensively investigated for its metabolic versatility including ability to produce hydrogen gas from sunlight and biomass. The availability of the finished g...
Gene networks driving bovine mammary protein synthesis during the lactation cycle [0.03%]
奶牛泌乳周期中驱动乳腺蛋白合成的基因网络
Massimo Bionaz,Juan J Loor
Massimo Bionaz
A crucial role for both insulin and mTOR in the regulation of milk protein synthesis is emerging. Bovine mammary biopsies harvested during late-pregnancy through end of subsequent lactation were used to evaluate via quantitative PCR the exp...
Mouse retinal development: a dark horse model for systems biology research [0.03%]
小鼠视网膜发育：系统生物学研究的一匹“黑马”模型
Xia Zhang,Jeanne M Serb,M Heather West Greenlee
Xia Zhang
The developing retina is an excellent model to study cellular fate determination and differentiation in the context of a complex tissue. Over the last decade, many basic principles and key genes that underlie these processes have been exper...
Amino Acid Features of P1B-ATPase Heavy Metal Transporters Enabling Small Numbers of Organisms to Cope with Heavy Metal Pollution [0.03%]
适应重金属污染的P1B-ATPase金属转运蛋白的氨基酸特征研究
E Ashrafi,A Alemzadeh,M Ebrahimi et al.
E Ashrafi et al.
Phytoremediation refers to the use of plants for extraction and detoxification of pollutants, providing a new and powerful weapon against a polluted environment. In some plants, such as Thlaspi spp, heavy metal ATPases are involved in overa...
Identification of drought-responsive universal stress proteins in viridiplantae [0.03%]
识别Viridiplantae中干旱响应的通用应激蛋白
Raphael D Isokpehi,Shaneka S Simmons,Hari H P Cohly et al.
Raphael D Isokpehi et al.
Genes encoding proteins that contain the universal stress protein (USP) domain are known to provide bacteria, archaea, fungi, protozoa, and plants with the ability to respond to a plethora of environmental stresses. Specifically in plants, ...
Conceptual aspects of large meta-analyses with publicly available microarray data: a case study in oncology [0.03%]
基于公共微阵列数据的大规模meta分析的概念方面：肿瘤学中的一个实例研究
Markus Schmidberger,Sabine Lennert,Ulrich Mansmann
Markus Schmidberger
Large public repositories of microarray experiments offer an abundance of biological data. It is of interest to use and to combine the available material to create new biological information and to develop a broader view on biological pheno...
Different Functional Gene Clusters in Yeast have Different Spatial Distributions of the Transcription Factor Binding Sites [0.03%]
酵母中不同功能基因簇的转录因子结合位点具有不同的空间分布特性
Wei-Sheng Wu
Wei-Sheng Wu
Transcription factors control gene expression by binding to short specific DNA sequences, called transcription factor binding sites (TFBSs), in the promoter of a gene. Thus, studying the spatial distribution of TFBSs in the promoters may pr...
Computational Analysis of Molecular Interaction Networks Underlying Change of HIV-1 Resistance to Selected Reverse Transcriptase Inhibitors [0.03%]
计算分析选定逆转录酶抑制剂作用下人类免疫缺陷病毒耐药性变化的分子相互作用网络
Marcin Kierczak,Michał Dramiński,Jacek Koronacki et al.
Marcin Kierczak et al.
Motivation: Despite more than two decades of research, HIV resistance to drugs remains a serious obstacle in developing efficient AIDS treatments. Several computational methods have been developed to predict resistance le...