R2eGIN: Residual Reconstruction Enhanced Graph Isomorphism Network for Accurate Prediction of Poly (ADP-Ribose) Polymerase Inhibitors [0.03%]
残差重建增强图同构网络在聚（腺苷二磷酸核糖）多聚酶抑制剂预测中的准确应用(R2eGIN)
Candra Zonyfar,Soualihou Ngnamsie Njimbouom,Sophia Mosalla et al.
Candra Zonyfar et al.
An advanced graph neural network (GNN) is of great promise to facilitate predicting Poly ADPribose polymerase inhibitors (PARPi). Recent studies design models by leveraging graph representations and molecular descriptor representations, unf...
In Silico Separation of in Vitro Transcription-Derived Duplicates From PCR Duplicates to Enhance Sequence Data Utilization [0.03%]
利用计算机分离体外转录衍生重复和PCR衍生重复以增强序列数据的利用率
Ryoga Suzuki,Kenichi Horisawa,Kazumitsu Maehara et al.
Ryoga Suzuki et al.
The polymerase chain reaction (PCR) amplification process of deoxyribonucleic acid (DNA) libraries can introduce bias in the sequence ratios. Consequently, several recent genomic and transcriptomic methods employing next-generation sequenci...
Repurposing terfenadine and domperidone for inhibition of apoptotic gene association in colorectal cancer: A system pharmacology approach integrated with molecular docking, MD simulations, and post-MD simulation analysis [0.03%]
将特非那定和多潘立酮重新定位为抑制结直肠癌凋亡基因关联：一种系统药理学方法，结合分子对接、MD模拟及后MD模拟分析
Pushpaveni C,Hemavathi S,Santosh Prasad Chaudhary Kurmi et al.
Pushpaveni C et al.
Colorectal cancer (CRC) remains a leading cause of global cancer mortality, underscoring the need for novel therapeutic strategies. This study used a systems pharmacology approach integrated with molecular docking and molecular dynamics (MD...
Newly Identified Genetic Associations of Alzheimer Disease by Conditional Selective Inference: Potential Implications for the Tau Hypothesis [0.03%]
条件选择推断新识别的与阿尔茨海默病相关的遗传关联及其对Tau假说的意义
Scott Hebert,Eric Nels Pederson,Zhengqing Ouyang
Scott Hebert
Over 6 million people are estimated to have been living with Alzheimer disease (AD) in 2020, with another 12 million living with Mild Cognitive Impairment (MCI). Research has been conducted to evaluate genetic links to AD, but more research...
Machine Learning Techniques in Chronic Kidney Diseases: A Comparative Study of Classification Model Performance [0.03%]
机器学习在慢性肾脏疾病中的应用：分类模型性能的比较研究
Nguyen Dong Phuong,Nguyen Trung Tuyen,Vu Thi Thai Linh et al.
Nguyen Dong Phuong et al.
The kidneys are vital organs responsible for filtering and eliminating toxins from the body. Chronic kidney disease (CKD) is becoming increasingly prevalent, affecting not only older adults but also younger populations. To minimize kidney d...
Trans-Cannabitriol as a Dual Inhibition of MPOX Adhesion Receptors L1R and E8L: An In Silico Perspective [0.03%]
基于计算机的跨大麻三醇作为MPOX黏附受体L1R和E8L的双抑制剂研究
Hanane Abbou,Razana Zegrari,Zainab Gaouzi et al.
Hanane Abbou et al.
The re-emergence of monkeypox virus (MPXV) as a global public health concern highlights the urgent need for novel therapeutic strategies targeting viral proteins essential for infection. This study investigates the inhibitory potential of T...
Konstantin Midlovets,Natalia Volkova,Mykyta Peka
Konstantin Midlovets
WNT proteins constitute a highly conserved family of signaling molecules that play an important role in regulating embryonic development and maintaining adult tissue homeostasis. Their diverse biological functions are mediated through multi...
Uncovering the Anti-Herpetic Activity of Anionic Peptides Derived From the Cytoplasmic Domain of Nectin-1 [0.03%]
来源于nectin-1胞质区的阴离子肽抗疱疹病毒活性研究
Rakesh Rahangdale,Sumit Birangal,Gautham Shenoy et al.
Rakesh Rahangdale et al.
Nectin-1/herpes simplex virus glycoprotein D (HSV gD) interaction is crucial to drive herpes simplex virus (HSV) entry. Polyanions are known to show great potential as antivirals. Thus, we explored a peptide-based biotherapeutic approach an...
Shared Genetic Characteristics of Coronary Artery Disease and Peripheral artery Disease: Insights From Integrated Bioinformatics Analysis of RNA-Sequencing Data [0.03%]
冠状动脉疾病和外周动脉疾病的共有遗传特征：来自整合生物信息学分析的RNA测序数据洞察
Abdul Qadir Nawabi,Lijuan Chen
Abdul Qadir Nawabi
Coronary artery disease (CAD) and peripheral artery disease have serious effects on quality of life. Recent studies have shown that peripheral arterial disorders increase a person's risk of developing CAD. The clinical symptoms of these con...
Immunoinformatics-Aided Design of a Multiepitope Vaccine Against Eimeria Tenella-Associated Chicken Coccidiosis [0.03%]
免疫信息学辅助设计鸡球虫病（Eimeria tenella）多表位疫苗
Adeyinka I Fadahunsi,Adewale J Atansuyi,Abayomi I Adebayo et al.
Adeyinka I Fadahunsi et al.
Avian coccidiosis, caused by Eimeria protozoa, presents a significant threat to poultry, with Eimeria tenella being particularly harmful due to its impact on the chicken cecum. Growing resistance to current treatments necessitates alternati...