Simple f test reveals gene-gene interactions in case-control studies [0.03%]
简单的F检验法在病例对照研究中发现基因-基因互作
Guanjie Chen,Ao Yuan,Jie Zhou et al.
Guanjie Chen et al.
Missing heritability is still a challenge for Genome Wide Association Studies (GWAS). Gene-gene interactions may partially explain this residual genetic influence and contribute broadly to complex disease. To analyze the gene-gene interacti...
DNA structural properties in the classification of genomic transcription regulation elements [0.03%]
基于DNA结构属性的基因组转录调控元件分类研究
Pieter Meysman,Kathleen Marchal,Kristof Engelen
Pieter Meysman
It has been long known that DNA molecules encode information at various levels. The most basic level comprises the base sequence itself and is primarily important for the encoding of proteins and direct base recognition by DNA-binding prote...
An Integrated Statistical Approach to Compare Transcriptomics Data Across Experiments: A Case Study on the Identification of Candidate Target Genes of the Transcription Factor PPARα [0.03%]
一种比较不同实验中转录组数据的统计方法及其在鉴定PPARα靶基因中的应用
Mohammad Ohid Ullah,Michael Müller,Guido J E J Hooiveld
Mohammad Ohid Ullah
An effective strategy to elucidate the signal transduction cascades activated by a transcription factor is to compare the transcriptional profiles of wild type and transcription factor knockout models. Many statistical tests have been propo...
The influence of taxon sampling and tree shape on molecular dating: an empirical example from Mammalian mitochondrial genomes [0.03%]
取样和系统树形状对分子钟定年的影响——以哺乳动物线粒体基因组为例
André E R Soares,Carlos G Schrago
André E R Soares
Over the last decade, molecular dating methods have been among the most studied subjects in statistical phylogenetics. Although the evolutionary modelling of substitution rates and the handling of calibration information are the primary foc...
Different evolutionary modifications as a guide to rewire two-component systems [0.03%]
不同的进化修改作为重连线粒体两组分系统的指导方针
Beate Krueger,Torben Friedrich,Frank Förster et al.
Beate Krueger et al.
Two-component systems (TCS) are short signalling pathways generally occurring in prokaryotes. They frequently regulate prokaryotic stimulus responses and thus are also of interest for engineering in biotechnology and synthetic biology. The ...
Transcriptome analysis in tardigrade species reveals specific molecular pathways for stress adaptations [0.03%]
水熊虫转录组分析发现压力适应的特异性分子通路
Frank Förster,Daniela Beisser,Markus A Grohme et al.
Frank Förster et al.
Tardigrades have unique stress-adaptations that allow them to survive extremes of cold, heat, radiation and vacuum. To study this, encoded protein clusters and pathways from an ongoing transcriptome study on the tardigrade Milnesium tardigr...
Guvanch Ovezmyradov,Qianhao Lu,Martin C Göpfert
Guvanch Ovezmyradov
The Gene Ontology (GO) initiative is a collaborative effort that uses controlled vocabularies for annotating genetic information. We here present AGENDA (Application for mining Gene Ontology Data), a novel web-based tool for accessing the G...
White blood cell differentials enrich whole blood expression data in the context of acute cardiac allograft rejection [0.03%]
白细胞分化丰富急性心脏移植物排斥的全血表达数据
Casey P Shannon,Zsuzsanna Hollander,Janet Wilson-McManus et al.
Casey P Shannon et al.
Acute cardiac allograft rejection is a serious complication of heart transplantation. Investigating molecular processes in whole blood via microarrays is a promising avenue of research in transplantation, particularly due to the non-invasiv...
Molecular Modelling of Oligomeric States of DmOR83b, an Olfactory Receptor in D. Melanogaster [0.03%]
拟南芥启动子组成型表达载体的构建及功能分析
K Harini,R Sowdhamini
K Harini
After the discovery of the complete repertoire of D. melanogaster Olfactory Receptors (ORs), candidate ORs have been identified from at least 12 insect species from four orders (Coleoptera, Lepidoptera, Diptera, and Hymenoptera), including ...
Computational design of targeted inhibitors of polo-like kinase 1 (plk1) [0.03%]
Polo样激酶1(Plk1)靶向抑制剂的计算设计
Krupa S Jani,D S Dalafave
Krupa S Jani
Computational design of small molecule putative inhibitors of Polo-like kinase 1 (Plk1) is presented. Plk1, which regulates the cell cycle, is often over expressed in cancers. Down regulation of Plk1 has been shown to inhibit tumor progress...