Methods of combinatorial optimization to reveal factors affecting gene length [0.03%]
组合优化方法揭示影响基因长度因素的手段
Alexander Bolshoy,Tatiana Tatarinova
Alexander Bolshoy
In this paper we present a novel method for genome ranking according to gene lengths. The main outcomes described in this paper are the following: the formulation of the genome ranking problem, presentation of relevant approaches to solve i...
Analyzing Thiol-Dependent Redox Networks in the Presence of Methylene Blue and Other Antimalarial Agents with RT-PCR-Supported in silico Modeling [0.03%]
基于RT-PCR的计算模型支持下分析甲烯蓝及其他抗疟疾药物共存时以硫醇依赖性氧化还原网络
J Zirkel,A Cecil,F Schäfer et al.
J Zirkel et al.
Background: In the face of growing resistance in malaria parasites to drugs, pharmacological combination therapies are important. There is accumulating evidence that methylene blue (MB) is an effective drug against malari...
Functional Annotation Analytics of Bacillus Genomes Reveals Stress Responsive Acetate Utilization and Sulfate Uptake in the Biotechnologically Relevant Bacillus megaterium [0.03%]
芽孢杆菌基因组功能注释揭示了模式菌株 Bacillus megaterium 在生物技术中的压力响应乙酸利用和硫酸盐吸收功能
Baraka S Williams,Raphael D Isokpehi,Andreas N Mbah et al.
Baraka S Williams et al.
Bacillus species form an heterogeneous group of Gram-positive bacteria that include members that are disease-causing, biotechnologically-relevant, and can serve as biological research tools. A common feature of Bacillus species is their abi...
Priscilla Rajadurai,Swamynathan Sankaranarayanan
Priscilla Rajadurai
Recently, microarray technologies have become a robust technique in the area of genomics. An important step in the analysis of gene expression data is the identification of groups of genes disclosing analogous expression patterns. Cluster a...
Homology modeling and molecular dynamics simulation studies of a marine alkaline protease [0.03%]
海洋碱性蛋白酶的同源模建及分子动力学模拟研究
Xiaofeng Ji,Wei Wang,Yuan Zheng et al.
Xiaofeng Ji et al.
A cold-adapted marine alkaline protease (MP, accession no. ACY25898) was produced by a marine bacterium strain, which was isolated from Yellow Sea sediment in China. Many previous researches showed that this protease had potential applicati...
Myosinome: a database of myosins from select eukaryotic genomes to facilitate analysis of sequence-structure-function relationships [0.03%]
肌球蛋白组：一个精选真核基因组的肌球蛋白数据库，用于分析序列-结构-功能关系
Divya P Syamaladevi,Margaret S Sunitha,S Kalaimathy et al.
Divya P Syamaladevi et al.
Myosins are one of the largest protein superfamilies with 24 classes. They have conserved structural features and catalytic domains yet show huge variation at different domains resulting in a variety of functions. Myosins are molecules driv...
The role of electrostatic interactions on klentaq1 insight for domain separation [0.03%]
静电作用在klentaq1结构域分离中的作用研究
Santi Nurbaiti,Muhamad A Martoprawiro,Akhmaloka et al.
Santi Nurbaiti et al.
We investigated the relationship between the thermostability of Klentaq1 and factors stabilizing interdomain interactions. When thermal adaptation of Klentaq1 was analyzed at the atomic level, the protein was stable at 300 and 350 K. It gra...
Integrative structural modelling of the cardiac thin filament: energetics at the interface and conservation patterns reveal a spotlight on period 2 of tropomyosin [0.03%]
心脏细肌丝的集成结构建模：界面能量学和保守模式揭示了肌浆 Regulatory protein tropomyosin 第2周期的重要作用
S Margaret Sunitha,John A Mercer,James A Spudich et al.
S Margaret Sunitha et al.
Cardiomyopathies are a major health problem, with inherited cardiomyopathies, many of which are caused by mutations in genes encoding sarcomeric proteins, constituting an ever-increasing fraction of cases. To begin to study the mechanisms b...
The core mouse response to infection by neospora caninum defined by gene set enrichment analyses [0.03%]
小鼠新型隐球菌感染的基因集富集分析定义的核心免疫反应
John Ellis,Stephen Goodswen,Paul J Kennedy et al.
John Ellis et al.
In this study, the BALB/c and Qs mouse responses to infection by the parasite Neospora caninum were investigated in order to identify host response mechanisms. Investigation was done using gene set (enrichment) analyses of microarray data. ...
Simultaneous Analysis of Common and Rare Variants in Complex Traits: Application to SNPs (SCARVAsnp) [0.03%]
复杂性状常见变异和稀有变异的联合分析及其在SNP中的应用(SCARVAsnp法)
Guanjie Chen,Ao Yuan,Yanxun Zhou et al.
Guanjie Chen et al.
Advances in technology and reduced costs are facilitating large-scale sequencing of genes and exomes as well as entire genomes. Recently, we described an approach based on haplotypes called SCARVA1 that enables the simultaneous analysis of ...