PathoAnalyzer-I: An Integrative Bioinformatics Platform for Chronic Disease Analysis [0.03%]
PathoAnalyzer-I：一种慢性疾病分析的整合生物信息学平台
Ali Aguerd,Faiza Bennis,Fatima Chegdani
Ali Aguerd
Chronic diseases impose a global health burden, contributing to high mortality and economic costs. Even with the recent surge in molecular data, these conditions remain largely incurable due to their biological complexity, data fragmentatio...
Metagenomic Profiling of Taxonomic and Functional Diversity in Soil Microbial Communities at Buffelsdraai Landfill, South Africa: Implications for Bioremediation [0.03%]
南非布费尔斯多拉伊填埋场土壤微生物群落的元基因组分析：对生物修复的意义
Xolani Mazibuko,Sbongile Mtimka,Lethukuthula M Ngobese et al.
Xolani Mazibuko et al.
Soil microbial communities in landfills play a crucial in waste degradation and pollution mitigation, yet their diversity and functionality in many regions remain underexplored. This study used shotgun metagenomic sequencing to characterise...
Systems Vaccinology-Integrated Proteomics to Develop a Novel Prophylactic and Therapeutic Vaccine Against Human Papillomavirus 16 [0.03%]
系统疫苗学：整合蛋白质组学研发针对人乳头瘤病毒16型的新型预防性和治疗性疫苗
Shirin Fathi,Aida Solhjoo,Ashkan Bagheri et al.
Shirin Fathi et al.
Cervical cancer remains a major global health burden, with high-risk human papillomavirus (HPV), particularly HPV-16, responsible for most cases. While licensed prophylactic HPV vaccines are effective, their type-restricted coverage and lac...
Pangenomics-Driven Reverse Vaccinology for the Discovery of New Vaccine Candidates Against Bordetella pertussis [0.03%]
泛基因组驱动的反向疫苗学在百日咳博德特氏菌疫苗新候选疫苗发现中的应用
Majid Abdelouahab,Diawara Idrissa
Majid Abdelouahab
Despite widespread vaccination, pertussis resurgence persists due to waning immunity and emerging resistant strains in Bordetella pertussis. This study employs a pangenomics-driven reverse vaccinology approach to identify novel vaccine cand...
Multi-Epitope mRNA Vaccine Targeting Dabie Bandavirus Glycoprotein: An Immunoinformatics-Based Study [0.03%]
基于免疫信息学的针对大巴山病毒糖蛋白的多抗原表位mRNA疫苗研究
Sk Faisal Ahmed,Md Shah Paran,Md Masudur Rahman Munna et al.
Sk Faisal Ahmed et al.
Dabie bandavirus (DBV), also called severe fever with thrombocytopenia syndrome virus (SFTSV), is a tick-borne virus that leads to a serious illness with high fever, low platelets, bleeding risks, and organ damage. Death rates can reach 5% ...
Comprehensive ceRNA Profiling Uncovers Clinically Relevant Hub lncRNAs in Glioblastoma [0.03%]
全面的ceRNA谱分析发现了胶质母细胞瘤中的临床相关核心lncRNA
Zohaib Rana,Joke Grans
Zohaib Rana
Long non-coding RNAs (lncRNAs) can function as competing endogenous RNAs (ceRNAs) that rewire post-transcriptional regulation in glioblastoma (GBM). Previous GBM studies have focused on either single lncRNA ceRNA axis in isolation or used i...
Combating Drug Resistance in Mycobacterium Tuberculosis: A Combinatorial in Silico and Experimental Modeling Approach Toward Novel ATP Synthase Inhibitor Discovery [0.03%]
结核分枝杆菌抗药性的对抗——基于联合计算及实验建模向新型ATP合成酶抑制剂研发的策略研究
Haidy H El-Zoheiry,Ratul Bhowmik,Ajay Manaithiya et al.
Haidy H El-Zoheiry et al.
Adenosine triphosphate (ATP) synthase in Mycobacterium tuberculosis (Mtb) is essential for energy metabolism through oxidative phosphorylation, where ATP is synthesized from ADP. This enzyme supports bacterial survival during both active gr...
EpigeneticAgePipeline: An R Package for Comprehensive Assessment of Epigenetic Age Metrics From Methylation Microarrays [0.03%]
表观遗传年龄评估R包EpigeneticAgePipeline：甲基化微阵列的综合分析工具
Stanislav Rayevskiy,Quinn Le,Julia Nguyen et al.
Stanislav Rayevskiy et al.
Epigenetic age is a biological age estimate based on nuclear DNA methylation patterns. Epigenetic clocks measure biological age by analyzing predictable changes in DNA methylation sites associated with aging. This study introduces Epigeneti...
ncRNA-Mediated Upregulation of AURKA Promotes Hepatocellular Carcinoma Progression and Alters the Immune Microenvironment [0.03%]
长链非编码RNA UCA1通过调控AURKA促进肝癌进展及重塑肿瘤免疫微环境
Zhitao Chen,Tianshu Chu,Chenchen Ding et al.
Zhitao Chen et al.
Hepatocellular carcinoma (HCC) remains a major cause of cancer-related mortality worldwide. Aurora kinase A (AURKA), a critical regulator of mitosis and spindle assembly, has been implicated in tumorigenesis, yet its clinical relevance and ...
Recent Progress in Sequence Optimization of mRNA Vaccine: Biological Mechanism, Quantitative Metrics, and Computational Model [0.03%]
mRNA疫苗的序列优化研究进展：生物机制、定量评价和计算模型
Yunwei Wang,Yuheng Cai,Zhixing Wu et al.
Yunwei Wang et al.
As a groundbreaking advancement in vaccinology, messenger RNA (mRNA) vaccines have transformed the field by offering rapid, flexible, and scalable solutions for combating infectious diseases. However, the efficacy, stability, and immunogeni...