Understanding the Impact of Individual Nucleotide on Oxford Nanopore Current Signals With Interpretable Prediction Models [0.03%]
具有解释性的预测模型揭示影响Oxford纳米孔电流信号的个体核苷酸的因素
Yenan Wang,Zhixing Wu,Jia Meng
Yenan Wang
Oxford nanopore sequencing enabled real-time, long-read analysis of DNA by detecting ionic current signals associated with K-mer sequences. Although many studies analyzed sequence and modification detection, our understanding of how multipl...
Metagenomic Insights Into Biopile Remediation of Petroleum-Contaminated Soil Using Chicken Droppings in Rivers State, Nigeria [0.03%]
尼日利亚河流州利用鸡粪生物堆修复受石油污染土壤的元基因组学见解
Emmanuel O Fenibo,Rosina Nkuna,Tonderayi Matambo
Emmanuel O Fenibo
Petroleum hydrocarbon pollution is an escalating global issue, particularly in developing countries, where it has attracted significant attention from researchers focusing on bioremediation, monitoring and sustainability. This study utilise...
Language Modelling Techniques for Analysing the Impact of Human Genetic Variation [0.03%]
语言建模技术在分析人类遗传变异影响中的应用
Megha Hegde,Jean-Christophe Nebel,Farzana Rahman
Megha Hegde
Interpreting the effects of variants within the human genome and proteome is essential for analysing disease risk, predicting medication response, and developing personalised health interventions. Due to the intrinsic similarities between t...
Repurposing of Anti-Infectives for the Management of Onchocerciasis Using Machine Learning and Protein Docking Studies [0.03%]
基于机器学习和蛋白质对接研究的抗感染药物治疗盘尾丝虫病的新用途
Cyril Tetteh,Andy Andoh Mensah,Bernice Ampomah et al.
Cyril Tetteh et al.
There is a need to improve the discovery of new drugs for neglected tropical diseases (NTDs), as the lack of financial incentives has slowed their development. Currently, ivermectin and moxidectin are used in the management of onchocerciasi...
R2eGIN: Residual Reconstruction Enhanced Graph Isomorphism Network for Accurate Prediction of Poly (ADP-Ribose) Polymerase Inhibitors [0.03%]
残差重建增强图同构网络在聚（腺苷二磷酸核糖）多聚酶抑制剂预测中的准确应用(R2eGIN)
Candra Zonyfar,Soualihou Ngnamsie Njimbouom,Sophia Mosalla et al.
Candra Zonyfar et al.
An advanced graph neural network (GNN) is of great promise to facilitate predicting Poly ADPribose polymerase inhibitors (PARPi). Recent studies design models by leveraging graph representations and molecular descriptor representations, unf...
In Silico Separation of in Vitro Transcription-Derived Duplicates From PCR Duplicates to Enhance Sequence Data Utilization [0.03%]
利用计算机分离体外转录衍生重复和PCR衍生重复以增强序列数据的利用率
Ryoga Suzuki,Kenichi Horisawa,Kazumitsu Maehara et al.
Ryoga Suzuki et al.
The polymerase chain reaction (PCR) amplification process of deoxyribonucleic acid (DNA) libraries can introduce bias in the sequence ratios. Consequently, several recent genomic and transcriptomic methods employing next-generation sequenci...
Repurposing terfenadine and domperidone for inhibition of apoptotic gene association in colorectal cancer: A system pharmacology approach integrated with molecular docking, MD simulations, and post-MD simulation analysis [0.03%]
将特非那定和多潘立酮重新定位为抑制结直肠癌凋亡基因关联：一种系统药理学方法，结合分子对接、MD模拟及后MD模拟分析
Pushpaveni C,Hemavathi S,Santosh Prasad Chaudhary Kurmi et al.
Pushpaveni C et al.
Colorectal cancer (CRC) remains a leading cause of global cancer mortality, underscoring the need for novel therapeutic strategies. This study used a systems pharmacology approach integrated with molecular docking and molecular dynamics (MD...
Newly Identified Genetic Associations of Alzheimer Disease by Conditional Selective Inference: Potential Implications for the Tau Hypothesis [0.03%]
条件选择推断新识别的与阿尔茨海默病相关的遗传关联及其对Tau假说的意义
Scott Hebert,Eric Nels Pederson,Zhengqing Ouyang
Scott Hebert
Over 6 million people are estimated to have been living with Alzheimer disease (AD) in 2020, with another 12 million living with Mild Cognitive Impairment (MCI). Research has been conducted to evaluate genetic links to AD, but more research...
Machine Learning Techniques in Chronic Kidney Diseases: A Comparative Study of Classification Model Performance [0.03%]
机器学习在慢性肾脏疾病中的应用：分类模型性能的比较研究
Nguyen Dong Phuong,Nguyen Trung Tuyen,Vu Thi Thai Linh et al.
Nguyen Dong Phuong et al.
The kidneys are vital organs responsible for filtering and eliminating toxins from the body. Chronic kidney disease (CKD) is becoming increasingly prevalent, affecting not only older adults but also younger populations. To minimize kidney d...
Trans-Cannabitriol as a Dual Inhibition of MPOX Adhesion Receptors L1R and E8L: An In Silico Perspective [0.03%]
基于计算机的跨大麻三醇作为MPOX黏附受体L1R和E8L的双抑制剂研究
Hanane Abbou,Razana Zegrari,Zainab Gaouzi et al.
Hanane Abbou et al.
The re-emergence of monkeypox virus (MPXV) as a global public health concern highlights the urgent need for novel therapeutic strategies targeting viral proteins essential for infection. This study investigates the inhibitory potential of T...