detectCilia: An R Package for Automated Detection and Length Measurement of Primary Cilia [0.03%]
detectCilia：一个用于原生纤毛自动检测和长度测量的R软件包
Kai Budde-Sagert,Simone Krueger,Clemens Sehlke et al.
Kai Budde-Sagert et al.
Background and objective: The primary cilium is a small protrusion found on most mammalian cells. It acts as a cellular antenna, being involved in various cell signaling pathways. The length of the primary cilium affects ...
Commitment Complex Splicing Factors in Cancers of the Gastrointestinal Tract-An In Silico Study [0.03%]
胃肠肿瘤中复杂的拼接因子-一项基于计算机的研究所见
Yun Zhang,Alexandria Carrasquillo Simko,Uzondu Okoro et al.
Yun Zhang et al.
The initial step in pre-mRNA splicing involves formation of a spliceosome commitment complex (CC) or E-complex by factors that serve to bind and mark the exon-intron boundaries that will undergo splicing. The CC component U1 snRNP assembles...
Intrinsically Disordered Compositional Bias in Proteins: Sequence Traits, Region Clustering, and Generation of Hypothetical Functional Associations [0.03%]
蛋白质内在无序的组成偏差：序列特征、区域聚类和假说功能关联生成
Paul M Harrison
Paul M Harrison
Compositionally biased regions (CBRs), ie, tracts that are dominated by a subset of residue types, are common features of eukaryotic proteins. These are often found bounded within or almost coterminous with intrinsically disordered or 'nati...
Structure, Inhibitors, and Biological Function in Nervous System and Cancer of Ubiquitin-Specific Protease 46 [0.03%]
泛素特异性蛋白酶46的结构、抑制剂及其在神经系统和癌症中的生物功能
Khanh Huyen Thi Pham,Manh Hung Tran,Le Ba Nam et al.
Khanh Huyen Thi Pham et al.
Deubiquitinating enzymes (DUBs) prevent ubiquitination by eliminating ubiquitin from their substrates. Deubiquitinating enzymes have important roles in a number of cell biology subfields that are highly relevant to diseases like neurodegene...
Taxonomic Distribution, Phylogenetic Relationship, and Domain Conservation of CRISPR-Associated Cas Proteins [0.03%]
CRISPR相关Cas蛋白的分类分布、系统发育关系和结构域保守性
Weerakkody Ranasinghe,Dorcie Gillette,Alexis Ho et al.
Weerakkody Ranasinghe et al.
CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) is a naturally occurring genetic defense system in bacteria and archaea. It is comprised of a series of DNA sequence repeats with spacers derived from previous exposures to ...
Coevolutionary Analysis of the Pfs47-P47Rec Complex: A Bioinformatics Approach [0.03%]
Pfs47-P47Rec复合体的协同进化分析——一种生物信息学方法
Andrés S Ortiz-Morazán,Marcela María Moncada,Denis Escobar et al.
Andrés S Ortiz-Morazán et al.
Background: The ability to predict and comprehend molecular interactions offers significant insights into the biological functions of proteins. The interaction between surface protein 47 of Plasmodium falciparum (Pfs47) a...
Investigating Lasofoxifene Efficacy Against the Y537S + F404V Double-Mutant Estrogen Receptor Alpha Using Molecular Dynamics Simulations [0.03%]
利用分子动力学模拟研究Lasofoxifene对Y537S+F404V双突变雌激素受体α的疗效
El Mehdi Bouricha,Mohammed Hakmi
El Mehdi Bouricha
Estrogen receptor alpha (ERα) plays a critical role in breast cancer (BC) progression, with endocrine therapy being a key treatment for ERα + BC. However, resistance often arises due to somatic mutations in the ERα ligand-binding domain ...
A Strategy to Compare Single-Cell RNA Sequencing Data Sets Provides Phenotypic Insight into Cellular Heterogeneity Underlying Biological Similarities and Differences Between Samples [0.03%]
比较单细胞RNA测序数据集的策略提供了关于样本之间生物学相似性和差异下的异质性表型见解
Dan C Wilkinson,Elizabeth Tallman,Mishal Ashraf et al.
Dan C Wilkinson et al.
Single-cell RNA sequencing (scRNA-seq) allows for an unbiased assessment of cellular phenotypes by enabling the extraction of transcriptomic data. An important question in downstream analysis is how to evaluate biological similarities and d...
Identification and Functional Annotation of Hypothetical Proteins of Pan-Drug-Resistant Providencia rettgeri Strain MRSN845308 Toward Designing Antimicrobial Drug Targets [0.03%]
耐多药泛菌_retteri株MRSN845308假蛋白的鉴定及功能注释以设计抗菌药物靶点
Dipta Chandra Pal,Tasnimul Arabi Anik,Atiq Abrar Rahman et al.
Dipta Chandra Pal et al.
Providencia rettgeri has increasingly been responsible for several infections, including urinary tract, post-burn wounds, neonatal sepsis, and others. The emergence of drug-resistant isolates of P rettgeri, accompanied by intrinsic and acqu...
Genetic Architectures of Medical Images Revealed by Registration of Multiple Modalities [0.03%]
基于多模式配准的医学图像遗传结构研究
Sam Freesun Friedman,Gemma Elyse Moran,Marianne Rakic et al.
Sam Freesun Friedman et al.
The advent of biobanks with vast quantities of medical imaging and paired genetic measurements creates huge opportunities for a new generation of genotype-phenotype association studies. However, disentangling biological signals from the man...